The effects of Al on the calcium currents in Helix neurons
1. The effects of aluminium (Al) on calcium (Ca) currents were investigated by using the conventional two-electrode voltage clamp technique in Helix pomatia neurons. The peak amplitude, kinetics, and voltage dependence of activation and inactivation of the Ca currents were studied in the presence of...
Gespeichert in:
| Veröffentlicht in: | Cellular and molecular neurobiology 1994-12, Vol.14 (6), p.809-818 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 818 |
|---|---|
| container_issue | 6 |
| container_start_page | 809 |
| container_title | Cellular and molecular neurobiology |
| container_volume | 14 |
| creator | Farkas, I Erdélyi, L |
| description | 1. The effects of aluminium (Al) on calcium (Ca) currents were investigated by using the conventional two-electrode voltage clamp technique in Helix pomatia neurons. The peak amplitude, kinetics, and voltage dependence of activation and inactivation of the Ca currents were studied in the presence of 10(-5)-10(-3) M AlCl3, at pH 6. 2. Al prolonged the rising phase of the Ca currents and therefore increased the time to peak at each command voltage step used. 3. There was no significant influence of Al on the peak amplitude of the Ca currents, but the voltage dependence of the time to peak, activation, and inactivation of the Ca currents shifted to more positive potentials as a consequence of Al treatment. 4. The leak currents were not influenced by Al up to 1 mM, which was the maximal dose applied. 5. The results support the suggestion that Al may modify the Ca homeostasis and that it exerts a neurotoxic effect, at least in part, by modulation of the Ca current of the neuronal membrane. |
| doi_str_mv | 10.1007/BF02088686 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_77110051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77110051</sourcerecordid><originalsourceid>FETCH-LOGICAL-p237t-b0e75fbb3aea2b1116f18231e3b87bebe6d78cdd0027f2d4626fcfeb3b414abc3</originalsourceid><addsrcrecordid>eNqFkL1PwzAQxT2ASiks7Eie2AJ3dmIbtlK1FKkSS5kj2zmLoHxhJxL890SiO9OT3vvp6e4xdoNwjwD64XkHAoxRRp2xJQgtslzmcMEuU_oEgEeAYsEWWuUopFmyp-MHcQqB_Jh4H_i64X3Hx9n0tvH11HI_xUjdnNYd31NTf_OOpth36YqdB9skuj7pir3vtsfNPju8vbxu1odsEFKPmQPSRXBOWrLCIaIKaIREks5oR45UpY2vKpiPDaLKlVDBB3LS5Zhb5-WK3f31DrH_miiNZVsnT01jO-qnVGqN8-cF_guimncBNDN4ewIn11JVDrFubfwpT6vIXzJvYFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16886018</pqid></control><display><type>article</type><title>The effects of Al on the calcium currents in Helix neurons</title><source>MEDLINE</source><source>SpringerNature Complete Journals</source><creator>Farkas, I ; Erdélyi, L</creator><creatorcontrib>Farkas, I ; Erdélyi, L</creatorcontrib><description>1. The effects of aluminium (Al) on calcium (Ca) currents were investigated by using the conventional two-electrode voltage clamp technique in Helix pomatia neurons. The peak amplitude, kinetics, and voltage dependence of activation and inactivation of the Ca currents were studied in the presence of 10(-5)-10(-3) M AlCl3, at pH 6. 2. Al prolonged the rising phase of the Ca currents and therefore increased the time to peak at each command voltage step used. 3. There was no significant influence of Al on the peak amplitude of the Ca currents, but the voltage dependence of the time to peak, activation, and inactivation of the Ca currents shifted to more positive potentials as a consequence of Al treatment. 4. The leak currents were not influenced by Al up to 1 mM, which was the maximal dose applied. 5. The results support the suggestion that Al may modify the Ca homeostasis and that it exerts a neurotoxic effect, at least in part, by modulation of the Ca current of the neuronal membrane.</description><identifier>ISSN: 0272-4340</identifier><identifier>DOI: 10.1007/BF02088686</identifier><identifier>PMID: 7641238</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Aluminum - pharmacology ; Aluminum - toxicity ; Animals ; Calcium - metabolism ; Calcium Channels - drug effects ; Calcium Channels - physiology ; Cell Membrane - drug effects ; Cell Membrane - physiology ; Dose-Response Relationship, Drug ; Freshwater ; Ganglia, Invertebrate - physiology ; Helix pomatia ; Helix, Snails ; Homeostasis ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Kinetics ; Membrane Potentials - drug effects ; Membrane Potentials - physiology ; Neurons - drug effects ; Neurons - physiology ; Time Factors</subject><ispartof>Cellular and molecular neurobiology, 1994-12, Vol.14 (6), p.809-818</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7641238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farkas, I</creatorcontrib><creatorcontrib>Erdélyi, L</creatorcontrib><title>The effects of Al on the calcium currents in Helix neurons</title><title>Cellular and molecular neurobiology</title><addtitle>Cell Mol Neurobiol</addtitle><description>1. The effects of aluminium (Al) on calcium (Ca) currents were investigated by using the conventional two-electrode voltage clamp technique in Helix pomatia neurons. The peak amplitude, kinetics, and voltage dependence of activation and inactivation of the Ca currents were studied in the presence of 10(-5)-10(-3) M AlCl3, at pH 6. 2. Al prolonged the rising phase of the Ca currents and therefore increased the time to peak at each command voltage step used. 3. There was no significant influence of Al on the peak amplitude of the Ca currents, but the voltage dependence of the time to peak, activation, and inactivation of the Ca currents shifted to more positive potentials as a consequence of Al treatment. 4. The leak currents were not influenced by Al up to 1 mM, which was the maximal dose applied. 5. The results support the suggestion that Al may modify the Ca homeostasis and that it exerts a neurotoxic effect, at least in part, by modulation of the Ca current of the neuronal membrane.</description><subject>Aluminum - pharmacology</subject><subject>Aluminum - toxicity</subject><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Calcium Channels - drug effects</subject><subject>Calcium Channels - physiology</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Freshwater</subject><subject>Ganglia, Invertebrate - physiology</subject><subject>Helix pomatia</subject><subject>Helix, Snails</subject><subject>Homeostasis</subject><subject>Hydrogen-Ion Concentration</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Membrane Potentials - drug effects</subject><subject>Membrane Potentials - physiology</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Time Factors</subject><issn>0272-4340</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAQxT2ASiks7Eie2AJ3dmIbtlK1FKkSS5kj2zmLoHxhJxL890SiO9OT3vvp6e4xdoNwjwD64XkHAoxRRp2xJQgtslzmcMEuU_oEgEeAYsEWWuUopFmyp-MHcQqB_Jh4H_i64X3Hx9n0tvH11HI_xUjdnNYd31NTf_OOpth36YqdB9skuj7pir3vtsfNPju8vbxu1odsEFKPmQPSRXBOWrLCIaIKaIREks5oR45UpY2vKpiPDaLKlVDBB3LS5Zhb5-WK3f31DrH_miiNZVsnT01jO-qnVGqN8-cF_guimncBNDN4ewIn11JVDrFubfwpT6vIXzJvYFA</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Farkas, I</creator><creator>Erdélyi, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>The effects of Al on the calcium currents in Helix neurons</title><author>Farkas, I ; Erdélyi, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-b0e75fbb3aea2b1116f18231e3b87bebe6d78cdd0027f2d4626fcfeb3b414abc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aluminum - pharmacology</topic><topic>Aluminum - toxicity</topic><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Calcium Channels - drug effects</topic><topic>Calcium Channels - physiology</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Freshwater</topic><topic>Ganglia, Invertebrate - physiology</topic><topic>Helix pomatia</topic><topic>Helix, Snails</topic><topic>Homeostasis</topic><topic>Hydrogen-Ion Concentration</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Membrane Potentials - drug effects</topic><topic>Membrane Potentials - physiology</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farkas, I</creatorcontrib><creatorcontrib>Erdélyi, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular and molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farkas, I</au><au>Erdélyi, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of Al on the calcium currents in Helix neurons</atitle><jtitle>Cellular and molecular neurobiology</jtitle><addtitle>Cell Mol Neurobiol</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>14</volume><issue>6</issue><spage>809</spage><epage>818</epage><pages>809-818</pages><issn>0272-4340</issn><abstract>1. The effects of aluminium (Al) on calcium (Ca) currents were investigated by using the conventional two-electrode voltage clamp technique in Helix pomatia neurons. The peak amplitude, kinetics, and voltage dependence of activation and inactivation of the Ca currents were studied in the presence of 10(-5)-10(-3) M AlCl3, at pH 6. 2. Al prolonged the rising phase of the Ca currents and therefore increased the time to peak at each command voltage step used. 3. There was no significant influence of Al on the peak amplitude of the Ca currents, but the voltage dependence of the time to peak, activation, and inactivation of the Ca currents shifted to more positive potentials as a consequence of Al treatment. 4. The leak currents were not influenced by Al up to 1 mM, which was the maximal dose applied. 5. The results support the suggestion that Al may modify the Ca homeostasis and that it exerts a neurotoxic effect, at least in part, by modulation of the Ca current of the neuronal membrane.</abstract><cop>Netherlands</cop><pmid>7641238</pmid><doi>10.1007/BF02088686</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0272-4340 |
| ispartof | Cellular and molecular neurobiology, 1994-12, Vol.14 (6), p.809-818 |
| issn | 0272-4340 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77110051 |
| source | MEDLINE; SpringerNature Complete Journals |
| subjects | Aluminum - pharmacology Aluminum - toxicity Animals Calcium - metabolism Calcium Channels - drug effects Calcium Channels - physiology Cell Membrane - drug effects Cell Membrane - physiology Dose-Response Relationship, Drug Freshwater Ganglia, Invertebrate - physiology Helix pomatia Helix, Snails Homeostasis Hydrogen-Ion Concentration In Vitro Techniques Kinetics Membrane Potentials - drug effects Membrane Potentials - physiology Neurons - drug effects Neurons - physiology Time Factors |
| title | The effects of Al on the calcium currents in Helix neurons |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T01%3A37%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effects%20of%20Al%20on%20the%20calcium%20currents%20in%20Helix%20neurons&rft.jtitle=Cellular%20and%20molecular%20neurobiology&rft.au=Farkas,%20I&rft.date=1994-12-01&rft.volume=14&rft.issue=6&rft.spage=809&rft.epage=818&rft.pages=809-818&rft.issn=0272-4340&rft_id=info:doi/10.1007/BF02088686&rft_dat=%3Cproquest_pubme%3E77110051%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16886018&rft_id=info:pmid/7641238&rfr_iscdi=true |