Molecular Properties of the “Ideal” Inhaled Anesthetic: Studies of Fluorinated Methanes, Ethanes, Propanes, and Butanes

We examined 35 unfluorinated, partially fluorinated, and perfluorinated methanes, ethanes, propanes, and butanes to define those molecular properties that best correlated with optimum solubility (low) and potency (high). Limited additional data were obtained on longer-chained alkanes. Using standard...

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Veröffentlicht in:	Anesthesia and analgesia 1994-08, Vol.79 (2), p.245-251
Hauptverfasser:	Eger, E. I, Liu, J., Koblin, D. D., Laster, M. J., Taheri, S., Halsey, M. J., Ionescu, P., Chortkoff, B. S., Hudlicky, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes - chemistry Anesthetics, Inhalation - chemistry Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Butanes - chemistry Ethane - chemistry Humans Hydrocarbons, Fluorinated - chemistry Hydrogenation Medical sciences Methane - chemistry Neuropharmacology Pharmacology. Drug treatments Pressure Propane - chemistry Rats Solubility
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