Metabolism of receptor targeted 111In-DTPA-glycoproteins: Identification of 111In-DTPA-ϵ-lysine as the primary metabolic and excretory product
The hepatic and renal retention of indium-111 ( 111In) from 111In-labeled polypeptides has been the subject of many investigations. Because the lysosome is a common intracellular destination for the degradation of polypeptides, we studied the lysosomal metabolism of 111In-DTPA-labeled glycoproteins...
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| Veröffentlicht in: | Nuclear medicine and biology 1994-11, Vol.21 (8), p.1023-1034 |
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| container_title | Nuclear medicine and biology |
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| creator | Franano, F.Nicholas Edwards, W.Barry Welch, Michael J. Duncan, James R. |
| description | The hepatic and renal retention of indium-111 (
111In) from
111In-labeled polypeptides has been the subject of many investigations. Because the lysosome is a common intracellular destination for the degradation of polypeptides, we studied the lysosomal metabolism of
111In-DTPA-labeled glycoproteins targeted to cell surface receptors
in vitro and
in vivo. We found that
111In-DTPA-glycoproteins were degraded to
111In-DTPA-ϵ-lysine, which was slowly released from cells and recovered intact in urine and feces. These results suggest a mechanism for
111In retention at target and non-target sites. |
| doi_str_mv | 10.1016/0969-8051(94)90174-0 |
| format | Article |
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111In) from
111In-labeled polypeptides has been the subject of many investigations. Because the lysosome is a common intracellular destination for the degradation of polypeptides, we studied the lysosomal metabolism of
111In-DTPA-labeled glycoproteins targeted to cell surface receptors
in vitro and
in vivo. We found that
111In-DTPA-glycoproteins were degraded to
111In-DTPA-ϵ-lysine, which was slowly released from cells and recovered intact in urine and feces. These results suggest a mechanism for
111In retention at target and non-target sites.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/0969-8051(94)90174-0</identifier><identifier>PMID: 9234360</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Cell Line ; Contrast media. Radiopharmaceuticals ; Feces - chemistry ; Female ; Glycoproteins - metabolism ; Kidney - metabolism ; Liver - metabolism ; Lysine - analogs & derivatives ; Lysine - analysis ; Lysine - metabolism ; Medical sciences ; Mice ; Pentetic Acid - analogs & derivatives ; Pentetic Acid - analysis ; Pentetic Acid - metabolism ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Tissue Distribution</subject><ispartof>Nuclear medicine and biology, 1994-11, Vol.21 (8), p.1023-1034</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-2f70dbc39117bd7d827a2e35cf158395583e86d0f7fc784f8a0a359a375a47a73</citedby><cites>FETCH-LOGICAL-c301t-2f70dbc39117bd7d827a2e35cf158395583e86d0f7fc784f8a0a359a375a47a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0969805194901740$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27902,27903,65308</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3452287$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9234360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franano, F.Nicholas</creatorcontrib><creatorcontrib>Edwards, W.Barry</creatorcontrib><creatorcontrib>Welch, Michael J.</creatorcontrib><creatorcontrib>Duncan, James R.</creatorcontrib><title>Metabolism of receptor targeted 111In-DTPA-glycoproteins: Identification of 111In-DTPA-ϵ-lysine as the primary metabolic and excretory product</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>The hepatic and renal retention of indium-111 (
111In) from
111In-labeled polypeptides has been the subject of many investigations. Because the lysosome is a common intracellular destination for the degradation of polypeptides, we studied the lysosomal metabolism of
111In-DTPA-labeled glycoproteins targeted to cell surface receptors
in vitro and
in vivo. We found that
111In-DTPA-glycoproteins were degraded to
111In-DTPA-ϵ-lysine, which was slowly released from cells and recovered intact in urine and feces. These results suggest a mechanism for
111In retention at target and non-target sites.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Contrast media. Radiopharmaceuticals</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Glycoproteins - metabolism</subject><subject>Kidney - metabolism</subject><subject>Liver - metabolism</subject><subject>Lysine - analogs & derivatives</subject><subject>Lysine - analysis</subject><subject>Lysine - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pentetic Acid - analogs & derivatives</subject><subject>Pentetic Acid - analysis</subject><subject>Pentetic Acid - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tissue Distribution</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcGOFCEUJMbNOq7-gSYcjNEDCg3dNB5MNquuk6zRw3omDDxWTHczAmOcr9iv8Tv8JemdzsSTFzhU1av3qhB6wugrRln3mqpOkZ627IUSLxVlUhB6D61YLxuiOibuo9WR8gA9zPk7rTLB6Ck6VQ0XvKMrdPsJitnEIeQRR48TWNiWmHAx6QYKOMwYW0_k3fWXc3Iz7G3cplggTPkNXjuYSvDBmhLiNKv_4f75TYZ9DhNgk3H5BnibwmjSHo-Ln8Vmchh-2QTVb1_x6Ha2PEIn3gwZHi__Gfr64f31xUdy9flyfXF-RSynrJDGS-o2livG5MZJ1zfSNMBb61nbc9XWB_rOUS-9lb3wvaGGt8pw2RohjeRn6PlhbvX9sYNc9BiyhWEwE8Rd1lIyqpgSlSgORJtizgm8Xi7RjOq5Bz2HrOeQtRL6rgdNq-zpMn-3GcEdRUvwFX-24CZbM_hkJhvykcZF2zT9vObbAw1qFj8DJJ1tgMmCC7Wqol0M_9_jL_kBpQI</recordid><startdate>199411</startdate><enddate>199411</enddate><creator>Franano, F.Nicholas</creator><creator>Edwards, W.Barry</creator><creator>Welch, Michael J.</creator><creator>Duncan, James R.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199411</creationdate><title>Metabolism of receptor targeted 111In-DTPA-glycoproteins: Identification of 111In-DTPA-ϵ-lysine as the primary metabolic and excretory product</title><author>Franano, F.Nicholas ; Edwards, W.Barry ; Welch, Michael J. ; Duncan, James R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-2f70dbc39117bd7d827a2e35cf158395583e86d0f7fc784f8a0a359a375a47a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Contrast media. Radiopharmaceuticals</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Glycoproteins - metabolism</topic><topic>Kidney - metabolism</topic><topic>Liver - metabolism</topic><topic>Lysine - analogs & derivatives</topic><topic>Lysine - analysis</topic><topic>Lysine - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pentetic Acid - analogs & derivatives</topic><topic>Pentetic Acid - analysis</topic><topic>Pentetic Acid - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franano, F.Nicholas</creatorcontrib><creatorcontrib>Edwards, W.Barry</creatorcontrib><creatorcontrib>Welch, Michael J.</creatorcontrib><creatorcontrib>Duncan, James R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franano, F.Nicholas</au><au>Edwards, W.Barry</au><au>Welch, Michael J.</au><au>Duncan, James R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism of receptor targeted 111In-DTPA-glycoproteins: Identification of 111In-DTPA-ϵ-lysine as the primary metabolic and excretory product</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>1994-11</date><risdate>1994</risdate><volume>21</volume><issue>8</issue><spage>1023</spage><epage>1034</epage><pages>1023-1034</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>The hepatic and renal retention of indium-111 (
111In) from
111In-labeled polypeptides has been the subject of many investigations. Because the lysosome is a common intracellular destination for the degradation of polypeptides, we studied the lysosomal metabolism of
111In-DTPA-labeled glycoproteins targeted to cell surface receptors
in vitro and
in vivo. We found that
111In-DTPA-glycoproteins were degraded to
111In-DTPA-ϵ-lysine, which was slowly released from cells and recovered intact in urine and feces. These results suggest a mechanism for
111In retention at target and non-target sites.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>9234360</pmid><doi>10.1016/0969-8051(94)90174-0</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0969-8051 |
| ispartof | Nuclear medicine and biology, 1994-11, Vol.21 (8), p.1023-1034 |
| issn | 0969-8051 1872-9614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77109194 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Cell Line Contrast media. Radiopharmaceuticals Feces - chemistry Female Glycoproteins - metabolism Kidney - metabolism Liver - metabolism Lysine - analogs & derivatives Lysine - analysis Lysine - metabolism Medical sciences Mice Pentetic Acid - analogs & derivatives Pentetic Acid - analysis Pentetic Acid - metabolism Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Tissue Distribution |
| title | Metabolism of receptor targeted 111In-DTPA-glycoproteins: Identification of 111In-DTPA-ϵ-lysine as the primary metabolic and excretory product |
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