The Generalized Consolidation of Articular Cartilage: An Investigation of Its Near-Physiological Response to Static Load

This paper presents a study of the response of articular cartilage to compression whilst measuring simultaneously its strain and fluid excess pore pressure using a newly developed experimental apparatus for testing the tissue in its unconfined state. This has provided a comparison of the load-induced responses of the cartilage matrix under axial, radial and 3-D consolidation regimes. Our results demonstrate that the patterns of the hydrostatic excess pore pressure for axial and 3-D consolidation are similar, but differ significantly from that obtained under the more physiologically relevant condition in which the matrix exhibits radial consolidation when loaded either through a non-porous polished stainless steel indenter or an opposing cartilage disc. Based on the transient strain characteristics obtained under axial and unconfined compression we argue that consolidation is indeed the controlling mechanism of cartilage biomechanical function.