Topical tretinoin for hair growth promotion
Topical all- trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of th...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1986-10, Vol.15 (4), p.880-893 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Bazzano, Gail S. Terezakis, Nia Galen, Wesley |
| description | Topical all-
trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the subjects studied. Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months. Tretinoin has been shown to promote and regulate cell proliferation and differentiation in the epithelium and may promote vascular proliferation. These factors are important for hair growth promotion. These preliminary results indicate that more work should be done on the role of retinoids in hair growth. The synergistic effect of retinoids in combination with a low concentration of minoxidil should also be further investigated. |
| doi_str_mv | 10.1016/S0190-9622(86)80024-X |
| format | Article |
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trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the subjects studied. Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months. Tretinoin has been shown to promote and regulate cell proliferation and differentiation in the epithelium and may promote vascular proliferation. These factors are important for hair growth promotion. These preliminary results indicate that more work should be done on the role of retinoids in hair growth. The synergistic effect of retinoids in combination with a low concentration of minoxidil should also be further investigated.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/S0190-9622(86)80024-X</identifier><identifier>PMID: 3771854</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Administration, Topical ; Adult ; Alopecia - drug therapy ; Drug Combinations ; Female ; Hair - drug effects ; Hair - growth & development ; Humans ; Male ; Middle Aged ; Minoxidil - administration & dosage ; Minoxidil - therapeutic use ; Stimulation, Chemical ; Tretinoin - administration & dosage ; Tretinoin - therapeutic use</subject><ispartof>Journal of the American Academy of Dermatology, 1986-10, Vol.15 (4), p.880-893</ispartof><rights>1986 American Academy of Dermatology, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-fb749c020f672542a28097cf94978a1c5ee3dc576e4fcce7ca20084ae75b36a53</citedby><cites>FETCH-LOGICAL-c360t-fb749c020f672542a28097cf94978a1c5ee3dc576e4fcce7ca20084ae75b36a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0190-9622(86)80024-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3771854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bazzano, Gail S.</creatorcontrib><creatorcontrib>Terezakis, Nia</creatorcontrib><creatorcontrib>Galen, Wesley</creatorcontrib><title>Topical tretinoin for hair growth promotion</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Topical all-
trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the subjects studied. Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months. Tretinoin has been shown to promote and regulate cell proliferation and differentiation in the epithelium and may promote vascular proliferation. These factors are important for hair growth promotion. These preliminary results indicate that more work should be done on the role of retinoids in hair growth. The synergistic effect of retinoids in combination with a low concentration of minoxidil should also be further investigated.</description><subject>Administration, Topical</subject><subject>Adult</subject><subject>Alopecia - drug therapy</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Hair - drug effects</subject><subject>Hair - growth & development</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minoxidil - administration & dosage</subject><subject>Minoxidil - therapeutic use</subject><subject>Stimulation, Chemical</subject><subject>Tretinoin - administration & dosage</subject><subject>Tretinoin - therapeutic use</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElPwzAQhS0EKmX5CZVyQiAUGDtekhNCFZtUiQNF6s1ynQk1SuJipyD-PemiXjnN4b03b-YjZEThhgKVt29AC0gLydhlLq9yAMbT2QEZUihUKlWuDslwbzkmJzF-AkDBMzUgg0wpmgs-JNdTv3TW1EkXsHOtd21S-ZAsjAvJR_A_3SJZBt_4zvn2jBxVpo54vpun5P3xYTp-TievTy_j-0lqMwldWs0VLywwqKRigjPD8v4kWxW8ULmhViBmpRVKIq-sRWUNA8i5QSXmmTQiOyUX271989cKY6cbFy3WtWnRr6LubwfBgPdGsTXa4GMMWOllcI0Jv5qCXkPSG0h6TUDnUm8g6VmfG-0KVvMGy31qR6XX77Y69l9-Oww6WoetxdIFtJ0uvfun4Q8ICnYa</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>Bazzano, Gail S.</creator><creator>Terezakis, Nia</creator><creator>Galen, Wesley</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861001</creationdate><title>Topical tretinoin for hair growth promotion</title><author>Bazzano, Gail S. ; Terezakis, Nia ; Galen, Wesley</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-fb749c020f672542a28097cf94978a1c5ee3dc576e4fcce7ca20084ae75b36a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Administration, Topical</topic><topic>Adult</topic><topic>Alopecia - drug therapy</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Hair - drug effects</topic><topic>Hair - growth & development</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minoxidil - administration & dosage</topic><topic>Minoxidil - therapeutic use</topic><topic>Stimulation, Chemical</topic><topic>Tretinoin - administration & dosage</topic><topic>Tretinoin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bazzano, Gail S.</creatorcontrib><creatorcontrib>Terezakis, Nia</creatorcontrib><creatorcontrib>Galen, Wesley</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bazzano, Gail S.</au><au>Terezakis, Nia</au><au>Galen, Wesley</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical tretinoin for hair growth promotion</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>15</volume><issue>4</issue><spage>880</spage><epage>893</epage><pages>880-893</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><abstract>Topical all-
trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the subjects studied. Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months. Tretinoin has been shown to promote and regulate cell proliferation and differentiation in the epithelium and may promote vascular proliferation. These factors are important for hair growth promotion. These preliminary results indicate that more work should be done on the role of retinoids in hair growth. The synergistic effect of retinoids in combination with a low concentration of minoxidil should also be further investigated.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>3771854</pmid><doi>10.1016/S0190-9622(86)80024-X</doi><tpages>14</tpages></addata></record> |
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| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 1986-10, Vol.15 (4), p.880-893 |
| issn | 0190-9622 1097-6787 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77105204 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Administration, Topical Adult Alopecia - drug therapy Drug Combinations Female Hair - drug effects Hair - growth & development Humans Male Middle Aged Minoxidil - administration & dosage Minoxidil - therapeutic use Stimulation, Chemical Tretinoin - administration & dosage Tretinoin - therapeutic use |
| title | Topical tretinoin for hair growth promotion |
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