Depletion of CD4+ and CD8 + Cells Eliminates Immunologic Memory of Thyroiditogenicity in Murine Experimental Autoimmune Thyroiditis

Experimental autoimmune thyroiditis (EAT) develops in genetically susceptible mice after immunization with mouse thyroglobulin (MTg), and is mediated by T cells, both CD4+ and CD8+, infiltrating the thyroid. Previous work showed that depletion of CD4 +, but not CD8 +, cells with rat monoclonal antib...

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Veröffentlicht in:	Autoimmunity (Chur, Switzerland) Switzerland), 1994, Vol.19 (3), p.161-168
Hauptverfasser:	Fuller, Brian E., Giraldo, Alvaro A., Waldmann, Herman, Cobbold, Stephen P., Kong, Yi-Chi M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Autoantibodies - blood Autoantibodies - immunology Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune Diseases - therapy Autoimmune thyroiditis Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Endocrinopathies Female Immunization Immunization, Secondary Immunologic Memory immunotherapy Immunotherapy, Adoptive Lymphocyte Depletion Lymphocyte Subsets Medical sciences Mice Mice, Inbred CBA monoclonal antibodies Non tumoral diseases. Target tissue resistance. Benign neoplasms Self Tolerance Spleen - immunology T cell depletion Thyroglobulin - immunology Thyroid Gland - pathology Thyroid. Thyroid axis (diseases) Thyroiditis, Autoimmune - immunology Thyroiditis, Autoimmune - pathology Thyroiditis, Autoimmune - therapy
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