Appraisal of a glycopeptide cloaking strategy for a therapeutic oligopeptide: Glycopeptide analogs of the renin inhibitor ditekiren

Among the limitations to the practical therapeutic oligopeptide are low oral availability, indifferent aqueous solubility, and an astonishingly efficient sequestration and biliary elimination by a multi-capacity liver transporter. Given the purposed use of N- and O- linked saccharides as functional...

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