Stereologic parameters of nuclear ultrastructure as markers of the steroid receptor status in breast cancer epithelium
The nuclear specific surface density (Sv/Vv), mean nuclear area (A) and numerical density (Nv) of tumor cell nuclei from 30 primary invasive female breast carcinomas with known concentrations of estrogen and progesterone receptors (ER and PR), were morphometrically analyzed at the ultrastructural le...
Gespeichert in:
| Veröffentlicht in: | Pathology, research and practice research and practice, 1994-12, Vol.190 (12), p.1162-1168 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1168 |
|---|---|
| container_issue | 12 |
| container_start_page | 1162 |
| container_title | Pathology, research and practice |
| container_volume | 190 |
| creator | Savjak, D. Pikula, B. Muss, W.H. Hacker, G.W. Amidzic, Lj Hauser-Kronberger, C. Lelic-Marinovic, M. Dietze, O. |
| description | The nuclear specific surface density (Sv/Vv), mean nuclear area (A) and numerical density (Nv) of tumor cell nuclei from 30 primary invasive female breast carcinomas with known concentrations of estrogen and progesterone receptors (ER and PR), were morphometrically analyzed at the ultrastructural level. It was found that carcinomas with concordant positive ER and PR status contained significantly higher number of smaller nuclei per volume unit of epithelium (mean Nv = 1.5 × 106 mm
−3, mean A-27 μm
2), than carcinomas of negative concordant receptor status (mean Nv = 0.8 × 10
6 mm
−3, mean = 37 μm
2). Tumor cell nuclei of the former frequently displayed an elliptic shape (mean Sv/Vv = 1.16 μm
−1), and had deeply invaginated surfaces, whereas nuclei of the latter were more frequently ball-shaped and exhibited a smooth-surface (mean Sv/Vv = 0.88 μm
−1).
The numerical density Nv (NUC/EPI) of tumor cell nuclei turned out to be a most reliable morphological marker of the concordant ER and PR status (overall efficiency = 84%, p < 0.01). The nuclear surface and volume ratio and mean nuclear area also appear to be reliable markers for terminal stages of the biochemical differentiation of breast carcinoma (overall efficiency = 79%, p < 0.05). |
| doi_str_mv | 10.1016/S0344-0338(11)80442-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77098608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0344033811804425</els_id><sourcerecordid>77098608</sourcerecordid><originalsourceid>FETCH-LOGICAL-c308t-2f2f9d94aaede6531a3cc2e0f296e33c82173fe53a155e7f8e61f5b6b7ce53b3</originalsourceid><addsrcrecordid>eNqFkMtKxDAUhoMo43h5BCEr0UU1aZq0XYkM3kBwMbMPaXqi0XZScxnw7Y3O4NZV4D_fn8P5EDqj5IoSKq6XhFVVQRhrLii9bEhVlQXfQ3MqaFMQweg-mv8hh-gohHdCSE0qOkOzum7LkvA52iwjeHCDe7UaT8qrEXIQsDN4nfQAyuM0RK9C9EnH5AGrgEflP3ZQfAMccsPZHnvQMEXnc6BiCtiucechV7FWaw0ew2QzP9g0nqADo4YAp7v3GK3u71aLx-L55eFpcftcaEaaWJSmNG3fVkpBD4IzqpjWJRBTtgIY001Ja2aAM0U5h9o0IKjhnehqncOOHaPz7beTd58JQpSjDRqGQa3BpSDrmrSNIE0G-RbU3oXgwcjJ23zml6RE_uiWv7rlj0tJqfzVLXnune0WpG6E_q-185vnN9s55CM3FrwM2kKW0dtsK8re2X82fAOjxJKt</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77098608</pqid></control><display><type>article</type><title>Stereologic parameters of nuclear ultrastructure as markers of the steroid receptor status in breast cancer epithelium</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Savjak, D. ; Pikula, B. ; Muss, W.H. ; Hacker, G.W. ; Amidzic, Lj ; Hauser-Kronberger, C. ; Lelic-Marinovic, M. ; Dietze, O.</creator><creatorcontrib>Savjak, D. ; Pikula, B. ; Muss, W.H. ; Hacker, G.W. ; Amidzic, Lj ; Hauser-Kronberger, C. ; Lelic-Marinovic, M. ; Dietze, O.</creatorcontrib><description>The nuclear specific surface density (Sv/Vv), mean nuclear area (A) and numerical density (Nv) of tumor cell nuclei from 30 primary invasive female breast carcinomas with known concentrations of estrogen and progesterone receptors (ER and PR), were morphometrically analyzed at the ultrastructural level. It was found that carcinomas with concordant positive ER and PR status contained significantly higher number of smaller nuclei per volume unit of epithelium (mean Nv = 1.5 × 106 mm
−3, mean A-27 μm
2), than carcinomas of negative concordant receptor status (mean Nv = 0.8 × 10
6 mm
−3, mean = 37 μm
2). Tumor cell nuclei of the former frequently displayed an elliptic shape (mean Sv/Vv = 1.16 μm
−1), and had deeply invaginated surfaces, whereas nuclei of the latter were more frequently ball-shaped and exhibited a smooth-surface (mean Sv/Vv = 0.88 μm
−1).
The numerical density Nv (NUC/EPI) of tumor cell nuclei turned out to be a most reliable morphological marker of the concordant ER and PR status (overall efficiency = 84%, p < 0.01). The nuclear surface and volume ratio and mean nuclear area also appear to be reliable markers for terminal stages of the biochemical differentiation of breast carcinoma (overall efficiency = 79%, p < 0.05).</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/S0344-0338(11)80442-5</identifier><identifier>PMID: 7792205</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Aged ; Biomarkers ; Breast carcinoma ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cell Nucleus - ultrastructure ; Epithelium - metabolism ; Epithelium - pathology ; Female ; Humans ; Middle Aged ; Models, Biological ; Prognosis ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Stereology ; Steroid recetors ; Ultrastructure</subject><ispartof>Pathology, research and practice, 1994-12, Vol.190 (12), p.1162-1168</ispartof><rights>1994 Gustav Fischer Verlag · Stuttgart · Jena · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c308t-2f2f9d94aaede6531a3cc2e0f296e33c82173fe53a155e7f8e61f5b6b7ce53b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0344-0338(11)80442-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7792205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Savjak, D.</creatorcontrib><creatorcontrib>Pikula, B.</creatorcontrib><creatorcontrib>Muss, W.H.</creatorcontrib><creatorcontrib>Hacker, G.W.</creatorcontrib><creatorcontrib>Amidzic, Lj</creatorcontrib><creatorcontrib>Hauser-Kronberger, C.</creatorcontrib><creatorcontrib>Lelic-Marinovic, M.</creatorcontrib><creatorcontrib>Dietze, O.</creatorcontrib><title>Stereologic parameters of nuclear ultrastructure as markers of the steroid receptor status in breast cancer epithelium</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>The nuclear specific surface density (Sv/Vv), mean nuclear area (A) and numerical density (Nv) of tumor cell nuclei from 30 primary invasive female breast carcinomas with known concentrations of estrogen and progesterone receptors (ER and PR), were morphometrically analyzed at the ultrastructural level. It was found that carcinomas with concordant positive ER and PR status contained significantly higher number of smaller nuclei per volume unit of epithelium (mean Nv = 1.5 × 106 mm
−3, mean A-27 μm
2), than carcinomas of negative concordant receptor status (mean Nv = 0.8 × 10
6 mm
−3, mean = 37 μm
2). Tumor cell nuclei of the former frequently displayed an elliptic shape (mean Sv/Vv = 1.16 μm
−1), and had deeply invaginated surfaces, whereas nuclei of the latter were more frequently ball-shaped and exhibited a smooth-surface (mean Sv/Vv = 0.88 μm
−1).
The numerical density Nv (NUC/EPI) of tumor cell nuclei turned out to be a most reliable morphological marker of the concordant ER and PR status (overall efficiency = 84%, p < 0.01). The nuclear surface and volume ratio and mean nuclear area also appear to be reliable markers for terminal stages of the biochemical differentiation of breast carcinoma (overall efficiency = 79%, p < 0.05).</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Breast carcinoma</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Epithelium - metabolism</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Prognosis</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Stereology</subject><subject>Steroid recetors</subject><subject>Ultrastructure</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMo43h5BCEr0UU1aZq0XYkM3kBwMbMPaXqi0XZScxnw7Y3O4NZV4D_fn8P5EDqj5IoSKq6XhFVVQRhrLii9bEhVlQXfQ3MqaFMQweg-mv8hh-gohHdCSE0qOkOzum7LkvA52iwjeHCDe7UaT8qrEXIQsDN4nfQAyuM0RK9C9EnH5AGrgEflP3ZQfAMccsPZHnvQMEXnc6BiCtiucechV7FWaw0ew2QzP9g0nqADo4YAp7v3GK3u71aLx-L55eFpcftcaEaaWJSmNG3fVkpBD4IzqpjWJRBTtgIY001Ja2aAM0U5h9o0IKjhnehqncOOHaPz7beTd58JQpSjDRqGQa3BpSDrmrSNIE0G-RbU3oXgwcjJ23zml6RE_uiWv7rlj0tJqfzVLXnune0WpG6E_q-185vnN9s55CM3FrwM2kKW0dtsK8re2X82fAOjxJKt</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Savjak, D.</creator><creator>Pikula, B.</creator><creator>Muss, W.H.</creator><creator>Hacker, G.W.</creator><creator>Amidzic, Lj</creator><creator>Hauser-Kronberger, C.</creator><creator>Lelic-Marinovic, M.</creator><creator>Dietze, O.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Stereologic parameters of nuclear ultrastructure as markers of the steroid receptor status in breast cancer epithelium</title><author>Savjak, D. ; Pikula, B. ; Muss, W.H. ; Hacker, G.W. ; Amidzic, Lj ; Hauser-Kronberger, C. ; Lelic-Marinovic, M. ; Dietze, O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c308t-2f2f9d94aaede6531a3cc2e0f296e33c82173fe53a155e7f8e61f5b6b7ce53b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Breast carcinoma</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Epithelium - metabolism</topic><topic>Epithelium - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Prognosis</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Stereology</topic><topic>Steroid recetors</topic><topic>Ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Savjak, D.</creatorcontrib><creatorcontrib>Pikula, B.</creatorcontrib><creatorcontrib>Muss, W.H.</creatorcontrib><creatorcontrib>Hacker, G.W.</creatorcontrib><creatorcontrib>Amidzic, Lj</creatorcontrib><creatorcontrib>Hauser-Kronberger, C.</creatorcontrib><creatorcontrib>Lelic-Marinovic, M.</creatorcontrib><creatorcontrib>Dietze, O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Savjak, D.</au><au>Pikula, B.</au><au>Muss, W.H.</au><au>Hacker, G.W.</au><au>Amidzic, Lj</au><au>Hauser-Kronberger, C.</au><au>Lelic-Marinovic, M.</au><au>Dietze, O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stereologic parameters of nuclear ultrastructure as markers of the steroid receptor status in breast cancer epithelium</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>190</volume><issue>12</issue><spage>1162</spage><epage>1168</epage><pages>1162-1168</pages><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>The nuclear specific surface density (Sv/Vv), mean nuclear area (A) and numerical density (Nv) of tumor cell nuclei from 30 primary invasive female breast carcinomas with known concentrations of estrogen and progesterone receptors (ER and PR), were morphometrically analyzed at the ultrastructural level. It was found that carcinomas with concordant positive ER and PR status contained significantly higher number of smaller nuclei per volume unit of epithelium (mean Nv = 1.5 × 106 mm
−3, mean A-27 μm
2), than carcinomas of negative concordant receptor status (mean Nv = 0.8 × 10
6 mm
−3, mean = 37 μm
2). Tumor cell nuclei of the former frequently displayed an elliptic shape (mean Sv/Vv = 1.16 μm
−1), and had deeply invaginated surfaces, whereas nuclei of the latter were more frequently ball-shaped and exhibited a smooth-surface (mean Sv/Vv = 0.88 μm
−1).
The numerical density Nv (NUC/EPI) of tumor cell nuclei turned out to be a most reliable morphological marker of the concordant ER and PR status (overall efficiency = 84%, p < 0.01). The nuclear surface and volume ratio and mean nuclear area also appear to be reliable markers for terminal stages of the biochemical differentiation of breast carcinoma (overall efficiency = 79%, p < 0.05).</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>7792205</pmid><doi>10.1016/S0344-0338(11)80442-5</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-0338 |
| ispartof | Pathology, research and practice, 1994-12, Vol.190 (12), p.1162-1168 |
| issn | 0344-0338 1618-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77098608 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged Biomarkers Breast carcinoma Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Nucleus - ultrastructure Epithelium - metabolism Epithelium - pathology Female Humans Middle Aged Models, Biological Prognosis Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Stereology Steroid recetors Ultrastructure |
| title | Stereologic parameters of nuclear ultrastructure as markers of the steroid receptor status in breast cancer epithelium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T21%3A25%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stereologic%20parameters%20of%20nuclear%20ultrastructure%20as%20markers%20of%20the%20steroid%20receptor%20status%20in%20breast%20cancer%20epithelium&rft.jtitle=Pathology,%20research%20and%20practice&rft.au=Savjak,%20D.&rft.date=1994-12-01&rft.volume=190&rft.issue=12&rft.spage=1162&rft.epage=1168&rft.pages=1162-1168&rft.issn=0344-0338&rft.eissn=1618-0631&rft_id=info:doi/10.1016/S0344-0338(11)80442-5&rft_dat=%3Cproquest_cross%3E77098608%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77098608&rft_id=info:pmid/7792205&rft_els_id=S0344033811804425&rfr_iscdi=true |