Disposition of propofol in patients undergoing surgery: a comparison in Men and Women
The disposition kinetics of propofol have been determined in 12 patients (six female) receiving propofol 2.5 mg kg-1 for induction of anaesthesia, which was maintained with 67% nitrous oxide in oxygen and 1-1.5% halothane. Peripheral blood samples were collected at selected times up to 8 h after the...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1986-10, Vol.58 (10), p.1075-1079 |
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| container_issue | 10 |
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| container_title | British journal of anaesthesia : BJA |
| container_volume | 58 |
| creator | KAY, N. H SEAR, J. W UPPINGTON, J COCKSHOTT, I. D DOUGLAS, E. J |
| description | The disposition kinetics of propofol have been determined in 12 patients (six female) receiving propofol 2.5 mg kg-1 for induction of anaesthesia, which was maintained with 67% nitrous oxide in oxygen and 1-1.5% halothane. Peripheral blood samples were collected at selected times up to 8 h after the injection of the drug, and whole blood propofol concentrations determined by HPLC with fluorescence detection. Drug concentration-time data were analysed by the non-linear regression program ELSFIT. This showed the data to be describable by a tri-exponential equation, corresponding to a three-compartment model. There were no differences in the derived kinetic indices for the male and female patients, with the exception of a greater Vdss:V gamma ratio in the males. The terminal half-life in the male patients was 262 min (SEM 44), and in the female patients 309 min (60). Vdss was 329 litre (67) and 313 litre (69) in male and female patients, respectively. The clearance in both groups was 1.8 litre min-1. Seven out of 12 patients showed significant secondary peaks in blood propofol concentration associated with recovery from anaesthesia. |
| doi_str_mv | 10.1093/bja/58.10.1075 |
| format | Article |
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The terminal half-life in the male patients was 262 min (SEM 44), and in the female patients 309 min (60). Vdss was 329 litre (67) and 313 litre (69) in male and female patients, respectively. The clearance in both groups was 1.8 litre min-1. Seven out of 12 patients showed significant secondary peaks in blood propofol concentration associated with recovery from anaesthesia.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/58.10.1075</identifier><identifier>PMID: 3490269</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Anesthesia, General ; Anesthetics - metabolism ; Anesthetics. Neuromuscular blocking agents ; Biological and medical sciences ; Female ; Humans ; Kinetics ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Pharmacology. 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W</creatorcontrib><creatorcontrib>UPPINGTON, J</creatorcontrib><creatorcontrib>COCKSHOTT, I. D</creatorcontrib><creatorcontrib>DOUGLAS, E. J</creatorcontrib><title>Disposition of propofol in patients undergoing surgery: a comparison in Men and Women</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>The disposition kinetics of propofol have been determined in 12 patients (six female) receiving propofol 2.5 mg kg-1 for induction of anaesthesia, which was maintained with 67% nitrous oxide in oxygen and 1-1.5% halothane. Peripheral blood samples were collected at selected times up to 8 h after the injection of the drug, and whole blood propofol concentrations determined by HPLC with fluorescence detection. Drug concentration-time data were analysed by the non-linear regression program ELSFIT. This showed the data to be describable by a tri-exponential equation, corresponding to a three-compartment model. There were no differences in the derived kinetic indices for the male and female patients, with the exception of a greater Vdss:V gamma ratio in the males. The terminal half-life in the male patients was 262 min (SEM 44), and in the female patients 309 min (60). Vdss was 329 litre (67) and 313 litre (69) in male and female patients, respectively. The clearance in both groups was 1.8 litre min-1. Seven out of 12 patients showed significant secondary peaks in blood propofol concentration associated with recovery from anaesthesia.</description><subject>Adult</subject><subject>Anesthesia, General</subject><subject>Anesthetics - metabolism</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenols - metabolism</subject><subject>Propofol</subject><subject>Surgical Procedures, Operative</subject><subject>Time Factors</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1PwzAQxS0EKqWwsiF5QGxp_ZHYMRsqn1IRSxFj5NiXylViBzsZ-t8TQcV0enq_e7p7CF1TsqRE8VW916uiXP5KWZygOc0lzYSU9BTNCSEyI4qyc3SR0p4QKpkqZmjGc0WYUHP0-ehSH5IbXPA4NLiPoQ9NaLHzuNeDAz8kPHoLcRec3-E0xh3Ewz3W2ISu19GlaXGC38Fj7S3-Ch34S3TW6DbB1XEu0Pb5abt-zTYfL2_rh03WM14MWcONphRszrS2xAC3BaEgQVBhmBI1p4ITZoklOTBhCVdApdCmFmBA1XyB7v5ip6u_R0hD1blkoG21hzCmSsrpd0HZBN4cwbHuwFZ9dJ2Oh-pYw-TfHn2djG6bqL1x6R-TZTkVV_IfXJNsmA</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>KAY, N. H</creator><creator>SEAR, J. W</creator><creator>UPPINGTON, J</creator><creator>COCKSHOTT, I. D</creator><creator>DOUGLAS, E. 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Neuromuscular blocking agents</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenols - metabolism</topic><topic>Propofol</topic><topic>Surgical Procedures, Operative</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAY, N. H</creatorcontrib><creatorcontrib>SEAR, J. W</creatorcontrib><creatorcontrib>UPPINGTON, J</creatorcontrib><creatorcontrib>COCKSHOTT, I. D</creatorcontrib><creatorcontrib>DOUGLAS, E. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disposition of propofol in patients undergoing surgery: a comparison in Men and Women</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>58</volume><issue>10</issue><spage>1075</spage><epage>1079</epage><pages>1075-1079</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>The disposition kinetics of propofol have been determined in 12 patients (six female) receiving propofol 2.5 mg kg-1 for induction of anaesthesia, which was maintained with 67% nitrous oxide in oxygen and 1-1.5% halothane. Peripheral blood samples were collected at selected times up to 8 h after the injection of the drug, and whole blood propofol concentrations determined by HPLC with fluorescence detection. Drug concentration-time data were analysed by the non-linear regression program ELSFIT. This showed the data to be describable by a tri-exponential equation, corresponding to a three-compartment model. There were no differences in the derived kinetic indices for the male and female patients, with the exception of a greater Vdss:V gamma ratio in the males. The terminal half-life in the male patients was 262 min (SEM 44), and in the female patients 309 min (60). Vdss was 329 litre (67) and 313 litre (69) in male and female patients, respectively. The clearance in both groups was 1.8 litre min-1. Seven out of 12 patients showed significant secondary peaks in blood propofol concentration associated with recovery from anaesthesia.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>3490269</pmid><doi>10.1093/bja/58.10.1075</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1986-10, Vol.58 (10), p.1075-1079 |
| issn | 0007-0912 1471-6771 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Oxford University Press Journals Digital Archive Legacy |
| subjects | Adult Anesthesia, General Anesthetics - metabolism Anesthetics. Neuromuscular blocking agents Biological and medical sciences Female Humans Kinetics Male Medical sciences Middle Aged Neuropharmacology Pharmacology. Drug treatments Phenols - metabolism Propofol Surgical Procedures, Operative Time Factors |
| title | Disposition of propofol in patients undergoing surgery: a comparison in Men and Women |
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