Serum-Soluble Receptors for Tumor Necrosis Factor-α and Interleukin-2, and Neopterin in Acute Rheumatic Fever
Immune activation may play an important role in the pathogenesis of acute rheumatic fever (ARF). The objective of the present study was to investigate serum concentrations of various markers of immune activation in ARF patients. Sera of 32 patients with ARF were investigated, 20 of them in follow-up...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1995-01, Vol.74 (1), p.31-34 |
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| container_title | Clinical immunology and immunopathology |
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| creator | Samsonov, M.Y. Tilz, G.P. Pisklakov, V.P. Reibnegger, G. Nassonov, E.L. Nassonova, V.A. Wachter, H. Fuchs, D. |
| description | Immune activation may play an important role in the pathogenesis of acute rheumatic fever (ARF). The objective of the present study was to investigate serum concentrations of various markers of immune activation in ARF patients. Sera of 32 patients with ARF were investigated, 20 of them in follow-up. Radioimmunoassay was used to quantify neopterin and ELISA for the measurement of 55-kDa-type soluble tumor necrosis factor receptor (sTNF-R) and soluble interleukin-2 receptor (sIL2-R). Markers of immune activation were found to be raised in 48% (sTNF-R), 28% (sIL2-R), and 78% (neopterin) of patients at the onset of ARF. There were significant correlations between the concentrations of neopterin and sTNF-R (rs = 0.60, P < 0.001) or sIL2-R (rs = 0.35, P < 0.05). Higher neopterin concentrations were found in patients with combined aortic and mitral insufficiency than in patients with mitral valve lesions alone (U = 2.67, P |
| doi_str_mv | 10.1006/clin.1995.1005 |
| format | Article |
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The objective of the present study was to investigate serum concentrations of various markers of immune activation in ARF patients. Sera of 32 patients with ARF were investigated, 20 of them in follow-up. Radioimmunoassay was used to quantify neopterin and ELISA for the measurement of 55-kDa-type soluble tumor necrosis factor receptor (sTNF-R) and soluble interleukin-2 receptor (sIL2-R). Markers of immune activation were found to be raised in 48% (sTNF-R), 28% (sIL2-R), and 78% (neopterin) of patients at the onset of ARF. There were significant correlations between the concentrations of neopterin and sTNF-R (rs = 0.60, P < 0.001) or sIL2-R (rs = 0.35, P < 0.05). Higher neopterin concentrations were found in patients with combined aortic and mitral insufficiency than in patients with mitral valve lesions alone (U = 2.67, P <0.05) or without valve lesion (U = 2.36, P < 0.05). Increased concentrations of neopterin, sTNF-R, and sIL2-R demonstrate activation of the cellular immune system in patients with ARF. Higher serum neopterin concentrations are associated with development of combined aortic and mitral insufficiency during the first episode of ARF.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1006/clin.1995.1005</identifier><identifier>PMID: 7994924</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute Disease ; Adolescent ; Adult ; Biomarkers - analysis ; Biopterins - analogs & derivatives ; Biopterins - metabolism ; Humans ; Male ; Neopterin ; Receptors, Drug - analysis ; Receptors, Interleukin-2 - analysis ; Receptors, Tumor Necrosis Factor - analysis ; Rheumatic Fever - immunology ; Rheumatic Fever - metabolism ; Rheumatic Fever - pathology ; Solubility ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Clinical immunology and immunopathology, 1995-01, Vol.74 (1), p.31-34</ispartof><rights>1995 Academic Press</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-66cf7e49766493fbb044d357bf1d8422cad60113f16e48d610f989da5be3423b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7994924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samsonov, M.Y.</creatorcontrib><creatorcontrib>Tilz, G.P.</creatorcontrib><creatorcontrib>Pisklakov, V.P.</creatorcontrib><creatorcontrib>Reibnegger, G.</creatorcontrib><creatorcontrib>Nassonov, E.L.</creatorcontrib><creatorcontrib>Nassonova, V.A.</creatorcontrib><creatorcontrib>Wachter, H.</creatorcontrib><creatorcontrib>Fuchs, D.</creatorcontrib><title>Serum-Soluble Receptors for Tumor Necrosis Factor-α and Interleukin-2, and Neopterin in Acute Rheumatic Fever</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>Immune activation may play an important role in the pathogenesis of acute rheumatic fever (ARF). The objective of the present study was to investigate serum concentrations of various markers of immune activation in ARF patients. Sera of 32 patients with ARF were investigated, 20 of them in follow-up. Radioimmunoassay was used to quantify neopterin and ELISA for the measurement of 55-kDa-type soluble tumor necrosis factor receptor (sTNF-R) and soluble interleukin-2 receptor (sIL2-R). Markers of immune activation were found to be raised in 48% (sTNF-R), 28% (sIL2-R), and 78% (neopterin) of patients at the onset of ARF. There were significant correlations between the concentrations of neopterin and sTNF-R (rs = 0.60, P < 0.001) or sIL2-R (rs = 0.35, P < 0.05). Higher neopterin concentrations were found in patients with combined aortic and mitral insufficiency than in patients with mitral valve lesions alone (U = 2.67, P <0.05) or without valve lesion (U = 2.36, P < 0.05). Increased concentrations of neopterin, sTNF-R, and sIL2-R demonstrate activation of the cellular immune system in patients with ARF. Higher serum neopterin concentrations are associated with development of combined aortic and mitral insufficiency during the first episode of ARF.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biomarkers - analysis</subject><subject>Biopterins - analogs & derivatives</subject><subject>Biopterins - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Neopterin</subject><subject>Receptors, Drug - analysis</subject><subject>Receptors, Interleukin-2 - analysis</subject><subject>Receptors, Tumor Necrosis Factor - analysis</subject><subject>Rheumatic Fever - immunology</subject><subject>Rheumatic Fever - metabolism</subject><subject>Rheumatic Fever - pathology</subject><subject>Solubility</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UMtKAzEUDaLUWt26E2blyql5zSPLUqwWioKt6zCT3MHoPGoyKfhZ_ojfZMYWd8Llvs65B-5B6JLgKcE4vVW1aadEiGQYkyM0JljgmDJOjtEYDz2hVJyiM-fecDjgOBuhUSYEF5SPUbsG65t43dW-rCF6BgXbvrMuqjobbXwT8iMo2znjokWhAhR_f0VFq6Nl24Otwb-bNqY3v6tH6LZhadooxEz5Pgi-gm-K3qhoATuw5-ikKmoHF4c6QS-Lu838IV493S_ns1WsGBN9nKaqyoCLLE25YFVZYs41S7KyIjrnlKpCp5gQVpEUeK5TgiuRC10kJTBOWckm6Hqvu7XdhwfXy8Y4BXVdtNB5J7MMC0JFHojTPXH40Vmo5NaaprCfkmA5GCwHg-Vg8DAm4eDqoOzLBvQf_eBowPM9DuG9nQErnTLQKtDGguql7sx_0j95jIq-</recordid><startdate>199501</startdate><enddate>199501</enddate><creator>Samsonov, M.Y.</creator><creator>Tilz, G.P.</creator><creator>Pisklakov, V.P.</creator><creator>Reibnegger, G.</creator><creator>Nassonov, E.L.</creator><creator>Nassonova, V.A.</creator><creator>Wachter, H.</creator><creator>Fuchs, D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199501</creationdate><title>Serum-Soluble Receptors for Tumor Necrosis Factor-α and Interleukin-2, and Neopterin in Acute Rheumatic Fever</title><author>Samsonov, M.Y. ; Tilz, G.P. ; Pisklakov, V.P. ; Reibnegger, G. ; Nassonov, E.L. ; Nassonova, V.A. ; Wachter, H. ; Fuchs, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-66cf7e49766493fbb044d357bf1d8422cad60113f16e48d610f989da5be3423b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biomarkers - analysis</topic><topic>Biopterins - analogs & derivatives</topic><topic>Biopterins - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Neopterin</topic><topic>Receptors, Drug - analysis</topic><topic>Receptors, Interleukin-2 - analysis</topic><topic>Receptors, Tumor Necrosis Factor - analysis</topic><topic>Rheumatic Fever - immunology</topic><topic>Rheumatic Fever - metabolism</topic><topic>Rheumatic Fever - pathology</topic><topic>Solubility</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Samsonov, M.Y.</creatorcontrib><creatorcontrib>Tilz, G.P.</creatorcontrib><creatorcontrib>Pisklakov, V.P.</creatorcontrib><creatorcontrib>Reibnegger, G.</creatorcontrib><creatorcontrib>Nassonov, E.L.</creatorcontrib><creatorcontrib>Nassonova, V.A.</creatorcontrib><creatorcontrib>Wachter, H.</creatorcontrib><creatorcontrib>Fuchs, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samsonov, M.Y.</au><au>Tilz, G.P.</au><au>Pisklakov, V.P.</au><au>Reibnegger, G.</au><au>Nassonov, E.L.</au><au>Nassonova, V.A.</au><au>Wachter, H.</au><au>Fuchs, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum-Soluble Receptors for Tumor Necrosis Factor-α and Interleukin-2, and Neopterin in Acute Rheumatic Fever</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1995-01</date><risdate>1995</risdate><volume>74</volume><issue>1</issue><spage>31</spage><epage>34</epage><pages>31-34</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><abstract>Immune activation may play an important role in the pathogenesis of acute rheumatic fever (ARF). The objective of the present study was to investigate serum concentrations of various markers of immune activation in ARF patients. Sera of 32 patients with ARF were investigated, 20 of them in follow-up. Radioimmunoassay was used to quantify neopterin and ELISA for the measurement of 55-kDa-type soluble tumor necrosis factor receptor (sTNF-R) and soluble interleukin-2 receptor (sIL2-R). Markers of immune activation were found to be raised in 48% (sTNF-R), 28% (sIL2-R), and 78% (neopterin) of patients at the onset of ARF. There were significant correlations between the concentrations of neopterin and sTNF-R (rs = 0.60, P < 0.001) or sIL2-R (rs = 0.35, P < 0.05). Higher neopterin concentrations were found in patients with combined aortic and mitral insufficiency than in patients with mitral valve lesions alone (U = 2.67, P <0.05) or without valve lesion (U = 2.36, P < 0.05). Increased concentrations of neopterin, sTNF-R, and sIL2-R demonstrate activation of the cellular immune system in patients with ARF. Higher serum neopterin concentrations are associated with development of combined aortic and mitral insufficiency during the first episode of ARF.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7994924</pmid><doi>10.1006/clin.1995.1005</doi><tpages>4</tpages></addata></record> |
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| ispartof | Clinical immunology and immunopathology, 1995-01, Vol.74 (1), p.31-34 |
| issn | 0090-1229 1090-2341 |
| language | eng |
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| subjects | Acute Disease Adolescent Adult Biomarkers - analysis Biopterins - analogs & derivatives Biopterins - metabolism Humans Male Neopterin Receptors, Drug - analysis Receptors, Interleukin-2 - analysis Receptors, Tumor Necrosis Factor - analysis Rheumatic Fever - immunology Rheumatic Fever - metabolism Rheumatic Fever - pathology Solubility Tumor Necrosis Factor-alpha - metabolism |
| title | Serum-Soluble Receptors for Tumor Necrosis Factor-α and Interleukin-2, and Neopterin in Acute Rheumatic Fever |
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