SEDATION OF CHILDREN REQUIRING ARTIFICIAL VENTILATION USING AN INFUSION OF MIDAZOLAM
The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubo-curarine). Sedation for patients breathing spontaneously with positive airwa...
Gespeichert in:
| Veröffentlicht in: | British journal of anaesthesia : BJA 1986-10, Vol.58 (10), p.1104-1108 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1108 |
|---|---|
| container_issue | 10 |
| container_start_page | 1104 |
| container_title | British journal of anaesthesia : BJA |
| container_volume | 58 |
| creator | BOOKER, P.D. BEECHEY, A. LLOYD-THOMAS, A.R. |
| description | The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubo-curarine). Sedation for patients breathing spontaneously with positive airway pressure was continued with midazolam alone. The duration of the midazolam infusion (2–6 μig kg−1 min−1) ranged from 12 to 197 h. Forty-seven of the children were sedated uneventfully; the remaining three children needed small doses of other sedative agents. In 10 of the children, blood samples were taken for serum midazolam assay and a short Synacthen test was performed. There was no clinical evidence of accumulation of midazolam, but midazolam concentrations were so variable that no conclusions could be drawn. All patients in whom they were measured (n = 10) had high basal cortisol concentrations, but displayed normal responses to Synacthen. |
| doi_str_mv | 10.1093/bja/58.10.1104 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77089151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0007091217392073</els_id><sourcerecordid>77089151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-9ce101ced38d9c28c6b0d927b78d2882048470b47ef61387bfe1716993e34f0e3</originalsourceid><addsrcrecordid>eNp1kE1v2zAMhoViQ5d2u-42wIehN6eiZZvS0UicRpjrYInTDb0ItiwD7vLRSsmw_fupdZDbTiTxPiSIh5DPQMdABbttnurbhI9fR6DxBRlBjBCmiPCOjCilGFIB0Qdy5dwTpYCRSC7JJUsYg4iOSLXKp1klF2WwmAWTuSymy7wMlvn3tVzK8i7IlpWcyYnMiuAhLytZDPB69RaWgSxnvh_W7-U0e1wU2f1H8r6rN858OtVrsp7l1WQeFos7OcmKUMdxegiFNkBBm5bxVuiI67ShrYiwQd5GnEc05jHSJkbTpcA4Np0BhFQIZljcUcOuyc1w99nuX47GHdS2d9psNvXO7I9OIVIuIAEPjgdQ271z1nTq2fbb2v5VQNWrRuU1qoS_jV6jX_hyunxstqY94ydvPv96ymun601n653u3RlDzgEZ81g4YL07mD_nuLa_VIoMEzX_-ajwG12VyH6o1PN84I239rs3Vjndm51X1FujD6rd9__7-B8JhpOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77089151</pqid></control><display><type>article</type><title>SEDATION OF CHILDREN REQUIRING ARTIFICIAL VENTILATION USING AN INFUSION OF MIDAZOLAM</title><source>Oxford University Press Journals Digital Archive legacy</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>BOOKER, P.D. ; BEECHEY, A. ; LLOYD-THOMAS, A.R.</creator><creatorcontrib>BOOKER, P.D. ; BEECHEY, A. ; LLOYD-THOMAS, A.R.</creatorcontrib><description>The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubo-curarine). Sedation for patients breathing spontaneously with positive airway pressure was continued with midazolam alone. The duration of the midazolam infusion (2–6 μig kg−1 min−1) ranged from 12 to 197 h. Forty-seven of the children were sedated uneventfully; the remaining three children needed small doses of other sedative agents. In 10 of the children, blood samples were taken for serum midazolam assay and a short Synacthen test was performed. There was no clinical evidence of accumulation of midazolam, but midazolam concentrations were so variable that no conclusions could be drawn. All patients in whom they were measured (n = 10) had high basal cortisol concentrations, but displayed normal responses to Synacthen.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/58.10.1104</identifier><identifier>PMID: 3533120</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cardiac Surgical Procedures ; Child ; Child, Preschool ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; Humans ; Infant ; Infusions, Intravenous ; Intensive care medicine ; Intermittent Positive-Pressure Ventilation ; Male ; Medical sciences ; Midazolam - administration & dosage ; Positive-Pressure Respiration ; Postoperative Care ; Time Factors</subject><ispartof>British journal of anaesthesia : BJA, 1986-10, Vol.58 (10), p.1104-1108</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-9ce101ced38d9c28c6b0d927b78d2882048470b47ef61387bfe1716993e34f0e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7881733$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3533120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOOKER, P.D.</creatorcontrib><creatorcontrib>BEECHEY, A.</creatorcontrib><creatorcontrib>LLOYD-THOMAS, A.R.</creatorcontrib><title>SEDATION OF CHILDREN REQUIRING ARTIFICIAL VENTILATION USING AN INFUSION OF MIDAZOLAM</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubo-curarine). Sedation for patients breathing spontaneously with positive airway pressure was continued with midazolam alone. The duration of the midazolam infusion (2–6 μig kg−1 min−1) ranged from 12 to 197 h. Forty-seven of the children were sedated uneventfully; the remaining three children needed small doses of other sedative agents. In 10 of the children, blood samples were taken for serum midazolam assay and a short Synacthen test was performed. There was no clinical evidence of accumulation of midazolam, but midazolam concentrations were so variable that no conclusions could be drawn. All patients in whom they were measured (n = 10) had high basal cortisol concentrations, but displayed normal responses to Synacthen.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cardiac Surgical Procedures</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infusions, Intravenous</subject><subject>Intensive care medicine</subject><subject>Intermittent Positive-Pressure Ventilation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Midazolam - administration & dosage</subject><subject>Positive-Pressure Respiration</subject><subject>Postoperative Care</subject><subject>Time Factors</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v2zAMhoViQ5d2u-42wIehN6eiZZvS0UicRpjrYInTDb0ItiwD7vLRSsmw_fupdZDbTiTxPiSIh5DPQMdABbttnurbhI9fR6DxBRlBjBCmiPCOjCilGFIB0Qdy5dwTpYCRSC7JJUsYg4iOSLXKp1klF2WwmAWTuSymy7wMlvn3tVzK8i7IlpWcyYnMiuAhLytZDPB69RaWgSxnvh_W7-U0e1wU2f1H8r6rN858OtVrsp7l1WQeFos7OcmKUMdxegiFNkBBm5bxVuiI67ShrYiwQd5GnEc05jHSJkbTpcA4Np0BhFQIZljcUcOuyc1w99nuX47GHdS2d9psNvXO7I9OIVIuIAEPjgdQ271z1nTq2fbb2v5VQNWrRuU1qoS_jV6jX_hyunxstqY94ydvPv96ymun601n653u3RlDzgEZ81g4YL07mD_nuLa_VIoMEzX_-ajwG12VyH6o1PN84I239rs3Vjndm51X1FujD6rd9__7-B8JhpOw</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>BOOKER, P.D.</creator><creator>BEECHEY, A.</creator><creator>LLOYD-THOMAS, A.R.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861001</creationdate><title>SEDATION OF CHILDREN REQUIRING ARTIFICIAL VENTILATION USING AN INFUSION OF MIDAZOLAM</title><author>BOOKER, P.D. ; BEECHEY, A. ; LLOYD-THOMAS, A.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-9ce101ced38d9c28c6b0d927b78d2882048470b47ef61387bfe1716993e34f0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cardiac Surgical Procedures</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infusions, Intravenous</topic><topic>Intensive care medicine</topic><topic>Intermittent Positive-Pressure Ventilation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Midazolam - administration & dosage</topic><topic>Positive-Pressure Respiration</topic><topic>Postoperative Care</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOOKER, P.D.</creatorcontrib><creatorcontrib>BEECHEY, A.</creatorcontrib><creatorcontrib>LLOYD-THOMAS, A.R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOOKER, P.D.</au><au>BEECHEY, A.</au><au>LLOYD-THOMAS, A.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SEDATION OF CHILDREN REQUIRING ARTIFICIAL VENTILATION USING AN INFUSION OF MIDAZOLAM</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>58</volume><issue>10</issue><spage>1104</spage><epage>1108</epage><pages>1104-1108</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubo-curarine). Sedation for patients breathing spontaneously with positive airway pressure was continued with midazolam alone. The duration of the midazolam infusion (2–6 μig kg−1 min−1) ranged from 12 to 197 h. Forty-seven of the children were sedated uneventfully; the remaining three children needed small doses of other sedative agents. In 10 of the children, blood samples were taken for serum midazolam assay and a short Synacthen test was performed. There was no clinical evidence of accumulation of midazolam, but midazolam concentrations were so variable that no conclusions could be drawn. All patients in whom they were measured (n = 10) had high basal cortisol concentrations, but displayed normal responses to Synacthen.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3533120</pmid><doi>10.1093/bja/58.10.1104</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1986-10, Vol.58 (10), p.1104-1108 |
| issn | 0007-0912 1471-6771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77089151 |
| source | Oxford University Press Journals Digital Archive legacy; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cardiac Surgical Procedures Child Child, Preschool Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Humans Infant Infusions, Intravenous Intensive care medicine Intermittent Positive-Pressure Ventilation Male Medical sciences Midazolam - administration & dosage Positive-Pressure Respiration Postoperative Care Time Factors |
| title | SEDATION OF CHILDREN REQUIRING ARTIFICIAL VENTILATION USING AN INFUSION OF MIDAZOLAM |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T21%3A31%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SEDATION%20OF%20CHILDREN%20REQUIRING%20ARTIFICIAL%20VENTILATION%20USING%20AN%20INFUSION%20OF%20MIDAZOLAM&rft.jtitle=British%20journal%20of%20anaesthesia%20:%20BJA&rft.au=BOOKER,%20P.D.&rft.date=1986-10-01&rft.volume=58&rft.issue=10&rft.spage=1104&rft.epage=1108&rft.pages=1104-1108&rft.issn=0007-0912&rft.eissn=1471-6771&rft.coden=BJANAD&rft_id=info:doi/10.1093/bja/58.10.1104&rft_dat=%3Cproquest_cross%3E77089151%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77089151&rft_id=info:pmid/3533120&rft_els_id=S0007091217392073&rfr_iscdi=true |