Oxidants Generated by the Myeloperoxidase-Halide System Activate the Fifth Component of Human Complement, C5

Hypochlorite and taurine chloramine (T-NCl) convert native fifth component of human complement (C5) to an activated state. This is evident from loss of functional properties of native C5 and acquisition of a binding site for C6 which is characteristic of C5b, the physiological activation fragment of...

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Veröffentlicht in:	Immunobiology (1979) 1994-12, Vol.192 (1), p.1-9
Hauptverfasser:	Vogt, Walther, Hesse, Dörte
Format:	Artikel
Sprache:	eng
Schlagworte:	Complement Activation - drug effects Complement C5 - metabolism Electrophoresis, Polyacrylamide Gel Humans Hypochlorous Acid - metabolism Hypochlorous Acid - pharmacology Methionine - metabolism Neutrophils - enzymology Oxidation-Reduction Peroxidase - metabolism Taurine - analogs & derivatives Taurine - metabolism Taurine - pharmacology
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