Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer's disease

Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer's disease

The aim of our experiments was to investigate the possible element concentration changes in Alzheimer's disease. Our project incorporated the determination of the regional distribution of elements in normal human brain, too. Five elements (Al, Zn, Cu, Mn and Fe) have been measured in 10 differe...

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Veröffentlicht in:Archives of gerontology and geriatrics 1995-07, Vol.21 (1), p.89-97
Hauptverfasser: Andrási, Erzsébet, Farkas, Éva, Scheibler, Henning, Réffy, Antal, Bezúr, László
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Sprache:eng
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Alzheimer's disease
Elements
ICP-AES
INAA
Normal human brain
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container_end_page 97
container_issue 1
container_start_page 89
container_title Archives of gerontology and geriatrics
container_volume 21
creator Andrási, Erzsébet
Farkas, Éva
Scheibler, Henning
Réffy, Antal
Bezúr, László
description The aim of our experiments was to investigate the possible element concentration changes in Alzheimer's disease. Our project incorporated the determination of the regional distribution of elements in normal human brain, too. Five elements (Al, Zn, Cu, Mn and Fe) have been measured in 10 different regions of 20 normal brains (mean age 70 years) and in brain parts of patients with Alzheimer's disease (9 individuals). Analyses were carried out by inductively coupled plasma atomic emission spectrometry (ICP-AES) and instrumental neutron activation analysis (INAA) techniques. Analytical precision and accuracy were investigated by NIST standard reference material. In a comparison between the healthy and Alzheimer patients' concentration data using statistical treatment these elements showed difference as a function of the Alzheimer disease (AD).
doi_str_mv 10.1016/0167-4943(95)00643-Y
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subjects Alzheimer's disease
Elements
ICP-AES
INAA
Normal human brain
title Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer's disease
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