Cerebral arteriovenous oxygen content difference during barbiturate therapy in patients with acute brain damage
This study evaluated the reliability of cerebral blood flow equivalent (CBFE), which was calculated as the reciprocal of cerebral arteriovenous oxygen content difference (C(av)DO2) as a monitor during barbiturate therapy in patients with cerebral ischemic insults. A barbiturate (thiamylal) was admin...
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| Veröffentlicht in: | Anesthesia and analgesia 1986-11, Vol.65 (11), p.1196-1200 |
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| container_title | Anesthesia and analgesia |
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| creator | SARI, A MATAYOSHI, Y YONEI, A OGASAHARA, H NONOUE, T YOKOTA, K YAMASHITA, S |
| description | This study evaluated the reliability of cerebral blood flow equivalent (CBFE), which was calculated as the reciprocal of cerebral arteriovenous oxygen content difference (C(av)DO2) as a monitor during barbiturate therapy in patients with cerebral ischemic insults. A barbiturate (thiamylal) was administered at a rate of 3 mg . kg-1 . hr-1 for 2-5 days to four patients who had suffered cardiac arrest, four with acute focal ischemia, two with postoperative brain edema after neurosurgery, and one with brain damage due to asphyxia. Four of the 11 patients completely recovered neurologically (recovery group), and others had neurological sequelae or died (nonrecovery group). The mean value of CBFE in the recovery group decreased significantly with barbiturate therapy to 13 +/- 1 ml blood/ml O2 from 39 +/- 3 ml blood/ml O2 but did not decrease in the nonrecovery group. We conclude that CBFE can be useful for monitoring the effect of barbiturate therapy in ischemic brain insults. |
| doi_str_mv | 10.1213/00000539-198611000-00017 |
| format | Article |
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A barbiturate (thiamylal) was administered at a rate of 3 mg . kg-1 . hr-1 for 2-5 days to four patients who had suffered cardiac arrest, four with acute focal ischemia, two with postoperative brain edema after neurosurgery, and one with brain damage due to asphyxia. Four of the 11 patients completely recovered neurologically (recovery group), and others had neurological sequelae or died (nonrecovery group). The mean value of CBFE in the recovery group decreased significantly with barbiturate therapy to 13 +/- 1 ml blood/ml O2 from 39 +/- 3 ml blood/ml O2 but did not decrease in the nonrecovery group. We conclude that CBFE can be useful for monitoring the effect of barbiturate therapy in ischemic brain insults.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/00000539-198611000-00017</identifier><identifier>PMID: 3767018</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. 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A barbiturate (thiamylal) was administered at a rate of 3 mg . kg-1 . hr-1 for 2-5 days to four patients who had suffered cardiac arrest, four with acute focal ischemia, two with postoperative brain edema after neurosurgery, and one with brain damage due to asphyxia. Four of the 11 patients completely recovered neurologically (recovery group), and others had neurological sequelae or died (nonrecovery group). The mean value of CBFE in the recovery group decreased significantly with barbiturate therapy to 13 +/- 1 ml blood/ml O2 from 39 +/- 3 ml blood/ml O2 but did not decrease in the nonrecovery group. We conclude that CBFE can be useful for monitoring the effect of barbiturate therapy in ischemic brain insults.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Barbiturates - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain Ischemia - drug therapy</subject><subject>Brain Ischemia - physiopathology</subject><subject>Cerebral Arteries</subject><subject>Cerebral Veins</subject><subject>Cerebrovascular Circulation</subject><subject>Emergency and intensive care: comas and nervous system diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic</subject><subject>Oxygen - blood</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE-PFCEQxYlxs46rH2ETDsZbKzTd_Dmaiasmm3hxz50Cilk2PfQItDrfXsYdh4SQ4r1XlfoRQjn7wHsuPrLTGYXpuNGS81Z07XL1gmz42MtOjUa_JJv2J7reGPOKvC7l6WRhWl6Ta6GkYlxvyLLFjDbDTCFXzHH5hWlZC13-HHeYqFtSxVSpjyE0Y3JI_Zpj2lEL2ca6ZqhI6yNmOBxpTPQANbZAob9jfaTg1ia39k3xsIcdviFXAeaCb8_vDXm4-_xj-7W7__7l2_bTfeeENrXTjoVeam6tkjCE3galrBy99qNoAKSUioPndhgGIzlT3DcJB-ahD4NALW7I--e-h7z8XLHUaR-Lw3mGhG2_SSmmRyaHZtTPRpeXUjKG6ZDjHvJx4mw6sZ7-s54urKd_rFv09jxjtXv0l-AZbtPfnXUoDuaQIblYLjZleqXHXvwFEJmIVg</recordid><startdate>19861101</startdate><enddate>19861101</enddate><creator>SARI, A</creator><creator>MATAYOSHI, Y</creator><creator>YONEI, A</creator><creator>OGASAHARA, H</creator><creator>NONOUE, T</creator><creator>YOKOTA, K</creator><creator>YAMASHITA, S</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861101</creationdate><title>Cerebral arteriovenous oxygen content difference during barbiturate therapy in patients with acute brain damage</title><author>SARI, A ; MATAYOSHI, Y ; YONEI, A ; OGASAHARA, H ; NONOUE, T ; YOKOTA, K ; YAMASHITA, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-8c0f2681bb76a4f2bf77b65d8d5312166671ad1b444961071dd8de40da2f43e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Barbiturates - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain Ischemia - drug therapy</topic><topic>Brain Ischemia - physiopathology</topic><topic>Cerebral Arteries</topic><topic>Cerebral Veins</topic><topic>Cerebrovascular Circulation</topic><topic>Emergency and intensive care: comas and nervous system diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monitoring, Physiologic</topic><topic>Oxygen - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SARI, A</creatorcontrib><creatorcontrib>MATAYOSHI, Y</creatorcontrib><creatorcontrib>YONEI, A</creatorcontrib><creatorcontrib>OGASAHARA, H</creatorcontrib><creatorcontrib>NONOUE, T</creatorcontrib><creatorcontrib>YOKOTA, K</creatorcontrib><creatorcontrib>YAMASHITA, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SARI, A</au><au>MATAYOSHI, Y</au><au>YONEI, A</au><au>OGASAHARA, H</au><au>NONOUE, T</au><au>YOKOTA, K</au><au>YAMASHITA, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral arteriovenous oxygen content difference during barbiturate therapy in patients with acute brain damage</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1986-11-01</date><risdate>1986</risdate><volume>65</volume><issue>11</issue><spage>1196</spage><epage>1200</epage><pages>1196-1200</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>This study evaluated the reliability of cerebral blood flow equivalent (CBFE), which was calculated as the reciprocal of cerebral arteriovenous oxygen content difference (C(av)DO2) as a monitor during barbiturate therapy in patients with cerebral ischemic insults. 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| ispartof | Anesthesia and analgesia, 1986-11, Vol.65 (11), p.1196-1200 |
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| source | Journals@OVID; MEDLINE; EZB Electronic Journals Library; Journals@Ovid Complete |
| subjects | Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Barbiturates - therapeutic use Biological and medical sciences Brain - metabolism Brain Ischemia - drug therapy Brain Ischemia - physiopathology Cerebral Arteries Cerebral Veins Cerebrovascular Circulation Emergency and intensive care: comas and nervous system diseases Female Humans Intensive care medicine Male Medical sciences Middle Aged Monitoring, Physiologic Oxygen - blood |
| title | Cerebral arteriovenous oxygen content difference during barbiturate therapy in patients with acute brain damage |
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