Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice

Inbred immunocompetent C57BL/6 mice have been a favored strain to study transgene expression of human blood coagulation factor IX (hF.IX) from viral vectors because systemic expression of the secreted protein is not limited by antibody responses following intravenous (i.v.) injection of vector. For...

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Veröffentlicht in:	Gene therapy 2001-03, Vol.8 (5), p.354-361
Hauptverfasser:	FIELDS, P. A, ARMSTRONG, E, HAGSTROM, J. N, ARRUDA, V. R, MURPHY, M. L, FARRELL, J. P, HIGH, K. A, HERZOG, R. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus E1 Proteins - genetics Adenovirus E3 Proteins - genetics Animals Biological and medical sciences Biotechnology Blood coagulation Cell Division - immunology Coagulation factor IX Coagulation factors Expression vectors Factor IX - immunology Freund's adjuvant Fundamental and applied biological sciences. Psychology Gene therapy Genetic Vectors Haplotypes Health. Pharmaceutical industry Immune Tolerance Immunogenicity Immunological tolerance Inbreeding Industrial applications and implications. Economical aspects Injection Injections, Intravenous Interleukin 10 Interleukin-10 - metabolism Intravenous administration Lymphocyte Activation - immunology Lymphocytes Male Mice Mice, Inbred BALB C Mice, Inbred C57BL T-Lymphocytes - immunology
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