Blunted adenosine A2a receptor function in platelets in patients with major depression
There is provisional evidence of involvement of adenosine in depression. In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically signific...
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| Veröffentlicht in: | European neuropsychopharmacology 2001-04, Vol.11 (2), p.183-186 |
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| container_title | European neuropsychopharmacology |
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| creator | Berk, Michael Plein, Helene Ferreira, Dulcie Jersky, Brian |
| description | There is provisional evidence of involvement of adenosine in depression. In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically significantly blunted second messenger response to agonist stimulation in the depressed group compared to the control group at the 50 and 100 nM and 1 μM dosage levels. This suggests that dysregulation of the adenosine A2a receptor may be present in depression. |
| doi_str_mv | 10.1016/S0924-977X(01)00074-8 |
| format | Article |
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In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically significantly blunted second messenger response to agonist stimulation in the depressed group compared to the control group at the 50 and 100 nM and 1 μM dosage levels. This suggests that dysregulation of the adenosine A2a receptor may be present in depression.</description><identifier>ISSN: 0924-977X</identifier><identifier>EISSN: 1873-7862</identifier><identifier>DOI: 10.1016/S0924-977X(01)00074-8</identifier><identifier>PMID: 11313166</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adenosine ; Adenosine - analogs & derivatives ; Adenosine A2a receptor ; Adolescent ; Adult ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Calcium ; Calcium - blood ; Depression ; Depressive Disorder - blood ; Dose-Response Relationship, Drug ; Female ; Fluorescent Dyes ; Fura-2 ; Humans ; Intracellular signalling ; Male ; Middle Aged ; Mood ; Phenethylamines ; Psychiatric Status Rating Scales ; Purinergic P1 Receptor Antagonists ; Receptor, Adenosine A2A ; Receptors, Purinergic P1 - blood ; Spectrometry, Fluorescence</subject><ispartof>European neuropsychopharmacology, 2001-04, Vol.11 (2), p.183-186</ispartof><rights>2001 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-c50c01a0da9be4a42a619a224f8f45919db80dc355b4feb195817d4fb3d92bee3</citedby><cites>FETCH-LOGICAL-c361t-c50c01a0da9be4a42a619a224f8f45919db80dc355b4feb195817d4fb3d92bee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0924-977X(01)00074-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11313166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berk, Michael</creatorcontrib><creatorcontrib>Plein, Helene</creatorcontrib><creatorcontrib>Ferreira, Dulcie</creatorcontrib><creatorcontrib>Jersky, Brian</creatorcontrib><title>Blunted adenosine A2a receptor function in platelets in patients with major depression</title><title>European neuropsychopharmacology</title><addtitle>Eur Neuropsychopharmacol</addtitle><description>There is provisional evidence of involvement of adenosine in depression. In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically significantly blunted second messenger response to agonist stimulation in the depressed group compared to the control group at the 50 and 100 nM and 1 μM dosage levels. This suggests that dysregulation of the adenosine A2a receptor may be present in depression.</description><subject>Adenosine</subject><subject>Adenosine - analogs & derivatives</subject><subject>Adenosine A2a receptor</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Depression</subject><subject>Depressive Disorder - blood</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fluorescent Dyes</subject><subject>Fura-2</subject><subject>Humans</subject><subject>Intracellular signalling</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mood</subject><subject>Phenethylamines</subject><subject>Psychiatric Status Rating Scales</subject><subject>Purinergic P1 Receptor Antagonists</subject><subject>Receptor, Adenosine A2A</subject><subject>Receptors, Purinergic P1 - blood</subject><subject>Spectrometry, Fluorescence</subject><issn>0924-977X</issn><issn>1873-7862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAQgIMo7rr6E5SeRA_VpE2b5iTr4gsWPPjAW0iTKWbppjVJFf-92Qd6lDnMDHwzw3wIHRN8QTApL58wz2jKGXs7w-QcY8xoWu2gMalYnrKqzHbR-BcZoQPvFxiTIs_5PhoRkscoyzF6vW4HG0AnUoPtvLGQTDOZOFDQh84lzWBVMJ1NjE36VgZoIfh1I4MBG-svE96TpVxEWEPvwPuIH6K9RrYejrZ5gl5ub55n9-n88e5hNp2nKi9JSFWBFSYSa8lroJJmsiRcZhltqoYWnHBdV1irvChq2kBNeFERpmlT55pnNUA-Qaebvb3rPgbwQSyNV9C20kI3eMEYZqykPILFBlSu895BI3pnltJ9C4LFSqhYCxUrWwITsRYqqjh3sj0w1EvQf1NbgxG42gAQ3_w04IRXUYwCbaLEIHRn_jnxA6bQhw0</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Berk, Michael</creator><creator>Plein, Helene</creator><creator>Ferreira, Dulcie</creator><creator>Jersky, Brian</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Blunted adenosine A2a receptor function in platelets in patients with major depression</title><author>Berk, Michael ; Plein, Helene ; Ferreira, Dulcie ; Jersky, Brian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-c50c01a0da9be4a42a619a224f8f45919db80dc355b4feb195817d4fb3d92bee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adenosine</topic><topic>Adenosine - analogs & derivatives</topic><topic>Adenosine A2a receptor</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Calcium</topic><topic>Calcium - blood</topic><topic>Depression</topic><topic>Depressive Disorder - blood</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fluorescent Dyes</topic><topic>Fura-2</topic><topic>Humans</topic><topic>Intracellular signalling</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mood</topic><topic>Phenethylamines</topic><topic>Psychiatric Status Rating Scales</topic><topic>Purinergic P1 Receptor Antagonists</topic><topic>Receptor, Adenosine A2A</topic><topic>Receptors, Purinergic P1 - blood</topic><topic>Spectrometry, Fluorescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berk, Michael</creatorcontrib><creatorcontrib>Plein, Helene</creatorcontrib><creatorcontrib>Ferreira, Dulcie</creatorcontrib><creatorcontrib>Jersky, Brian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berk, Michael</au><au>Plein, Helene</au><au>Ferreira, Dulcie</au><au>Jersky, Brian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blunted adenosine A2a receptor function in platelets in patients with major depression</atitle><jtitle>European neuropsychopharmacology</jtitle><addtitle>Eur Neuropsychopharmacol</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>11</volume><issue>2</issue><spage>183</spage><epage>186</epage><pages>183-186</pages><issn>0924-977X</issn><eissn>1873-7862</eissn><abstract>There is provisional evidence of involvement of adenosine in depression. In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically significantly blunted second messenger response to agonist stimulation in the depressed group compared to the control group at the 50 and 100 nM and 1 μM dosage levels. This suggests that dysregulation of the adenosine A2a receptor may be present in depression.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>11313166</pmid><doi>10.1016/S0924-977X(01)00074-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | European neuropsychopharmacology, 2001-04, Vol.11 (2), p.183-186 |
| issn | 0924-977X 1873-7862 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenosine Adenosine - analogs & derivatives Adenosine A2a receptor Adolescent Adult Blood Platelets - drug effects Blood Platelets - metabolism Calcium Calcium - blood Depression Depressive Disorder - blood Dose-Response Relationship, Drug Female Fluorescent Dyes Fura-2 Humans Intracellular signalling Male Middle Aged Mood Phenethylamines Psychiatric Status Rating Scales Purinergic P1 Receptor Antagonists Receptor, Adenosine A2A Receptors, Purinergic P1 - blood Spectrometry, Fluorescence |
| title | Blunted adenosine A2a receptor function in platelets in patients with major depression |
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