E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma

In diffuse gastric carcinoma, despite common E-cadherin gene (CDH1) mutations, tumors show absence of CDH1 loss of heterozigosity (LOH) in most cases. This observation challenges the classical two-hit model of tumor suppressor gene inactivation. In order to investigate whether or not CDH1 promoter m...

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Veröffentlicht in:	Oncogene 2001-03, Vol.20 (12), p.1525-1528
Hauptverfasser:	MACHADO, J. C, OLIVEIRA, C, CARVALHO, R, SOARES, P, BERX, G, CALDAS, C, SERUCA, R, CARNEIRO, F, SOBRINHO-SIMOES, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - etiology Adenocarcinoma - genetics Biological and medical sciences Cadherins - genetics Cancer Carcinoma CDH1 gene Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA Methylation E-cadherin Fundamental and applied biological sciences. Psychology Gastric cancer gastric carcinoma Humans Intestine Models, Genetic Molecular and cellular biology Mutation Promoter Regions, Genetic Stomach Neoplasms - etiology Stomach Neoplasms - genetics Tumor suppressor genes Tumors
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