Regression of Canine Oral Papillomas Is Associated with Infiltration of CD4+ and CD8+ Lymphocytes
Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. Immunohistochemical analysis of the timing and phenotype of immune...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2001-04, Vol.283 (1), p.31-39 |
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| container_title | Virology (New York, N.Y.) |
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| creator | Nicholls, Philip K. Moore, Peter F. Anderson, Davina M. Moore, Richard A. Parry, Nigel R. Gough, Gerald W. Stanley, Margaret A. |
| description | Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. Immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant CD4+ and CD8+ cells, with CD4+ cells being most numerous. Comparison of these findings, and those of immunohistochemistry using TCRαβ-, TCRγδ-, CD1a-, CD1c-, CD11a-, CD11b-, CD11c-, CD18-, CD21-, and CD49d-specific monoclonal antibodies, with previously published work in the human, ox, and rabbit models revealed important differences between these systems. Unlike bovine papillomavirus lesions, those of COPV do not have a significant gamma/delta T-cell infiltrate. Furthermore, COPV lesions had numerous CD4+ cells, unlike cottontail rabbit papillomavirus lesions. The lymphocyte infiltrate in the dog resembled that in human papillomavirus lesions, indicating that COPV is an appropriate model for human papillomavirus immunity. |
| doi_str_mv | 10.1006/viro.2000.0789 |
| format | Article |
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The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. Immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant CD4+ and CD8+ cells, with CD4+ cells being most numerous. Comparison of these findings, and those of immunohistochemistry using TCRαβ-, TCRγδ-, CD1a-, CD1c-, CD11a-, CD11b-, CD11c-, CD18-, CD21-, and CD49d-specific monoclonal antibodies, with previously published work in the human, ox, and rabbit models revealed important differences between these systems. Unlike bovine papillomavirus lesions, those of COPV do not have a significant gamma/delta T-cell infiltrate. Furthermore, COPV lesions had numerous CD4+ cells, unlike cottontail rabbit papillomavirus lesions. 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The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. Immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant CD4+ and CD8+ cells, with CD4+ cells being most numerous. Comparison of these findings, and those of immunohistochemistry using TCRαβ-, TCRγδ-, CD1a-, CD1c-, CD11a-, CD11b-, CD11c-, CD18-, CD21-, and CD49d-specific monoclonal antibodies, with previously published work in the human, ox, and rabbit models revealed important differences between these systems. Unlike bovine papillomavirus lesions, those of COPV do not have a significant gamma/delta T-cell infiltrate. Furthermore, COPV lesions had numerous CD4+ cells, unlike cottontail rabbit papillomavirus lesions. The lymphocyte infiltrate in the dog resembled that in human papillomavirus lesions, indicating that COPV is an appropriate model for human papillomavirus immunity.</description><subject>animal models</subject><subject>Animals</subject><subject>Canine oral papillomavirus</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>COPV</subject><subject>Disease Models, Animal</subject><subject>Dog Diseases - immunology</subject><subject>Dog Diseases - virology</subject><subject>Dogs</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>HPV</subject><subject>Humans</subject><subject>immunity</subject><subject>Immunohistochemistry</subject><subject>Mouth Mucosa - immunology</subject><subject>Mouth Neoplasms - immunology</subject><subject>Mouth Neoplasms - veterinary</subject><subject>Papilloma - immunology</subject><subject>Papilloma - veterinary</subject><subject>Papillomaviridae - immunology</subject><subject>papillomavirus</subject><subject>Papillomavirus Infections - immunology</subject><subject>Papillomavirus Infections - veterinary</subject><subject>Remission, Spontaneous</subject><subject>Tumor Virus Infections - immunology</subject><subject>Tumor Virus Infections - veterinary</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL9P6zAUhS0Egj5gZUSeWFDKdZzY8YjKj1epEgjBbLn2DRglcbFTUP97ErXoTU9M9wzfOdL9CDljMGUA4urTxzDNAWAKslJ7ZMJAiQx4wfbJBKDIM1Hl-RH5k9L7QBVSwiE5YoyzXJRqQswTvkZMyYeOhprOTOc7pA_RNPTRrHzThNYkOk_0OqVgvenR0S_fv9F5V_umj6b_ad4Ul9R0bgjVJV1s2tVbsJse0wk5qE2T8HR3j8nL3e3z7G-2eLifz64XmeUF7zNbKLQOeC4ZSisYE-WyFKaWAhhTztRK5SVDJaual2Atz5VbLgWgK5ni0vJjcrHdXcXwscbU69Yni01jOgzrpIfPpRBV9SvIBpGCqxGcbkEbQ0oRa72KvjVxoxno0b4e7evRvh7tD4Xz3fJ62aL7h-90D0C1BXAQ8ekx6mQ9dhadj2h77YL_3_Y3NFiSYA</recordid><startdate>20010425</startdate><enddate>20010425</enddate><creator>Nicholls, Philip K.</creator><creator>Moore, Peter F.</creator><creator>Anderson, Davina M.</creator><creator>Moore, Richard A.</creator><creator>Parry, Nigel R.</creator><creator>Gough, Gerald W.</creator><creator>Stanley, Margaret A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010425</creationdate><title>Regression of Canine Oral Papillomas Is Associated with Infiltration of CD4+ and CD8+ Lymphocytes</title><author>Nicholls, Philip K. ; Moore, Peter F. ; Anderson, Davina M. ; Moore, Richard A. ; Parry, Nigel R. ; Gough, Gerald W. ; Stanley, Margaret A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-c49ecd03271e7c61165b56af760119daf99251e978f350cc329dbb60ed51937c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>animal models</topic><topic>Animals</topic><topic>Canine oral papillomavirus</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>COPV</topic><topic>Disease Models, Animal</topic><topic>Dog Diseases - immunology</topic><topic>Dog Diseases - virology</topic><topic>Dogs</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>HPV</topic><topic>Humans</topic><topic>immunity</topic><topic>Immunohistochemistry</topic><topic>Mouth Mucosa - immunology</topic><topic>Mouth Neoplasms - immunology</topic><topic>Mouth Neoplasms - veterinary</topic><topic>Papilloma - immunology</topic><topic>Papilloma - veterinary</topic><topic>Papillomaviridae - immunology</topic><topic>papillomavirus</topic><topic>Papillomavirus Infections - immunology</topic><topic>Papillomavirus Infections - veterinary</topic><topic>Remission, Spontaneous</topic><topic>Tumor Virus Infections - immunology</topic><topic>Tumor Virus Infections - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nicholls, Philip K.</creatorcontrib><creatorcontrib>Moore, Peter F.</creatorcontrib><creatorcontrib>Anderson, Davina M.</creatorcontrib><creatorcontrib>Moore, Richard A.</creatorcontrib><creatorcontrib>Parry, Nigel R.</creatorcontrib><creatorcontrib>Gough, Gerald W.</creatorcontrib><creatorcontrib>Stanley, Margaret A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nicholls, Philip K.</au><au>Moore, Peter F.</au><au>Anderson, Davina M.</au><au>Moore, Richard A.</au><au>Parry, Nigel R.</au><au>Gough, Gerald W.</au><au>Stanley, Margaret A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regression of Canine Oral Papillomas Is Associated with Infiltration of CD4+ and CD8+ Lymphocytes</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>2001-04-25</date><risdate>2001</risdate><volume>283</volume><issue>1</issue><spage>31</spage><epage>39</epage><pages>31-39</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. Immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant CD4+ and CD8+ cells, with CD4+ cells being most numerous. Comparison of these findings, and those of immunohistochemistry using TCRαβ-, TCRγδ-, CD1a-, CD1c-, CD11a-, CD11b-, CD11c-, CD18-, CD21-, and CD49d-specific monoclonal antibodies, with previously published work in the human, ox, and rabbit models revealed important differences between these systems. Unlike bovine papillomavirus lesions, those of COPV do not have a significant gamma/delta T-cell infiltrate. Furthermore, COPV lesions had numerous CD4+ cells, unlike cottontail rabbit papillomavirus lesions. 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| subjects | animal models Animals Canine oral papillomavirus CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes COPV Disease Models, Animal Dog Diseases - immunology Dog Diseases - virology Dogs Enzyme-Linked Immunosorbent Assay Female HPV Humans immunity Immunohistochemistry Mouth Mucosa - immunology Mouth Neoplasms - immunology Mouth Neoplasms - veterinary Papilloma - immunology Papilloma - veterinary Papillomaviridae - immunology papillomavirus Papillomavirus Infections - immunology Papillomavirus Infections - veterinary Remission, Spontaneous Tumor Virus Infections - immunology Tumor Virus Infections - veterinary |
| title | Regression of Canine Oral Papillomas Is Associated with Infiltration of CD4+ and CD8+ Lymphocytes |
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