Expanding the Genetic Code of Escherichia coli

A unique transfer RNA (tRNA)/aminoacyl-tRNA synthetase pair has been generated that expands the number of genetically encoded amino acids in Escherichia coli. When introduced into E. coli, this pair leads to the in vivo incorporation of the synthetic amino acid O-methyl-L-tyrosine into protein in re...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2001-04, Vol.292 (5516), p.498-500
Hauptverfasser:	Wang, Lei, Brock, Ansgar, Herberich, Brad, Schultz, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid metabolism Amino acids Anticodon Bacteria Bacteriology Biochemistry Biological and medical sciences Chemicals Chromatography Codon - genetics Codon - metabolism Codon, Terminator Codons Escherichia coli Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology General aspects Genetic aspects Genetic Code Genetic mutation Genetics Libraries Mass Spectrometry Methanococcus - enzymology Methanococcus - genetics Methods Methyltyrosines - metabolism Microbiology Mutation Plasmids Protein Biosynthesis Protein research Protein synthesis Ribonucleic acid RNA RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism RNA, Transfer, Tyr - genetics RNA, Transfer, Tyr - metabolism Suppression, Genetic Transfer RNA Transfer RNA Aminoacylation Transformation, Bacterial Translation Tyrosine-tRNA Ligase - chemistry Tyrosine-tRNA Ligase - genetics Tyrosine-tRNA Ligase - metabolism Virology
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