Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2

The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analysis to identify novel E2F target genes. We show that E2F-1 up-regulates the expression of a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncogene 2001-03, Vol.20 (11), p.1379-1387
Hauptverfasser: KALMA, Yael, MARASH, Lea, LAMED, Yocheved, GINSBERG, Doron
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1387
container_issue 11
container_start_page 1379
container_title Oncogene
container_volume 20
creator KALMA, Yael
MARASH, Lea
LAMED, Yocheved
GINSBERG, Doron
description The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analysis to identify novel E2F target genes. We show that E2F-1 up-regulates the expression of a number of genes coding for components of the DNA replication machinery. Among them is the gene coding for the 32 Kd subunit of replication protein A (RPA2). Replication protein A is the most abundant single strand DNA binding complex and it is essential for DNA replication. We demonstrate that RPA2 is a novel E2F target gene whose expression can be directly regulated by E2F-1 via E2F binding sites in its promoter. In addition, expression of Topoisomerase IIalpha and subunit IV of DNA polymerase alpha is also up-regulated upon E2F-1 induction. Taken together, these results provide novel links between components of the DNA replication machinery and the cell growth regulatory pathway involving the Rb tumor suppressor and E2F.
doi_str_mv 10.1038/sj.onc.1204230
format Article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_77075475</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A200390000</galeid><sourcerecordid>A200390000</sourcerecordid><originalsourceid>FETCH-LOGICAL-c512t-86d75fb0987f82f27ff03640e4e862970daa75db9498c932099196d80c51f0a33</originalsourceid><addsrcrecordid>eNqFksGO0zAQhiMEYsvClSOKQOKWMrbj2D5WSxeQVnCBs-U6dnGV2MWTSNvn4IVxl4qu0CLkg6XxN_-MZ_6qeklgSYDJd7hbpmiXhEJLGTyqFqQVXcO5ah9XC1AcGkUZvaieIe4AQCigT6sLQhhhUpJF9XN9u88OMaRYm2iGAwasZwxxW7__vKrHYHMyOZsD1r0bU8Qpm8lhPX03U72m1w2p532T3XYe7uLuLJf8nUR2-yFYMx1DWxcLE6Id5v5Y4v7bPqfJhViv6PPqiTcDuhen-7L6dr3-evWxufny4dPV6qaxnNCpkV0vuN-AksJL6qnwHljXgmud7KgS0BsjeL9RrZJWMQpKEdX1Ekq6B8PYZfX2t24p_WN2OOkxoHXDYKJLM2ohQPBW8P-CREguhSQFfPMXuEtzLmNFTbu2DL0F0hXq9T8pKhhwKeVZamsGp0P0qUzeHuvqFQVgqmwTCrV8gCqnLCvYFJ0PJf5QQtkrYnZe73MYTT5oAvroKI07XRylT44qCa9Ozc6b0fVn_GShe382aM3gs4k24B9OqU4oyX4BltTSBw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>227305888</pqid></control><display><type>article</type><title>Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>KALMA, Yael ; MARASH, Lea ; LAMED, Yocheved ; GINSBERG, Doron</creator><creatorcontrib>KALMA, Yael ; MARASH, Lea ; LAMED, Yocheved ; GINSBERG, Doron</creatorcontrib><description>The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analysis to identify novel E2F target genes. We show that E2F-1 up-regulates the expression of a number of genes coding for components of the DNA replication machinery. Among them is the gene coding for the 32 Kd subunit of replication protein A (RPA2). Replication protein A is the most abundant single strand DNA binding complex and it is essential for DNA replication. We demonstrate that RPA2 is a novel E2F target gene whose expression can be directly regulated by E2F-1 via E2F binding sites in its promoter. In addition, expression of Topoisomerase IIalpha and subunit IV of DNA polymerase alpha is also up-regulated upon E2F-1 induction. Taken together, these results provide novel links between components of the DNA replication machinery and the cell growth regulatory pathway involving the Rb tumor suppressor and E2F.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1204230</identifier><identifier>PMID: 11313881</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Antigens, Neoplasm ; Base Sequence ; Binding sites ; Biological and medical sciences ; Carrier Proteins ; Cell cycle ; Cell Cycle Proteins ; Cell cycle, cell proliferation ; Cell growth ; Cell physiology ; Deoxyribonucleic acid ; DNA ; DNA biosynthesis ; DNA microarrays ; DNA polymerase ; DNA Polymerase I - biosynthesis ; DNA Replication - genetics ; DNA Topoisomerases, Type II - biosynthesis ; DNA-Binding Proteins - biosynthesis ; DNA-Binding Proteins - genetics ; DNA-directed DNA polymerase ; E2F protein ; E2F Transcription Factors ; E2F-1 protein ; E2F1 protein ; E2F1 Transcription Factor ; Fundamental and applied biological sciences. Psychology ; Gene Expression Profiling ; Genes ; Humans ; Isoenzymes - biosynthesis ; Kinases ; Molecular and cellular biology ; Molecular Sequence Data ; Oligonucleotide Array Sequence Analysis ; Oligonucleotides ; Promoter Regions, Genetic ; Protein Subunits ; Proteins ; RB protein ; Replication Protein A ; Retinoblastoma-Binding Protein 1 ; Transcription Factor DP1 ; Transcription Factors - metabolism ; Tumor suppressor genes ; Tumors ; Up-Regulation</subject><ispartof>Oncogene, 2001-03, Vol.20 (11), p.1379-1387</ispartof><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 15, 2001</rights><rights>Macmillan Publishers Limited 2001.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-86d75fb0987f82f27ff03640e4e862970daa75db9498c932099196d80c51f0a33</citedby><cites>FETCH-LOGICAL-c512t-86d75fb0987f82f27ff03640e4e862970daa75db9498c932099196d80c51f0a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=996798$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11313881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KALMA, Yael</creatorcontrib><creatorcontrib>MARASH, Lea</creatorcontrib><creatorcontrib>LAMED, Yocheved</creatorcontrib><creatorcontrib>GINSBERG, Doron</creatorcontrib><title>Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analysis to identify novel E2F target genes. We show that E2F-1 up-regulates the expression of a number of genes coding for components of the DNA replication machinery. Among them is the gene coding for the 32 Kd subunit of replication protein A (RPA2). Replication protein A is the most abundant single strand DNA binding complex and it is essential for DNA replication. We demonstrate that RPA2 is a novel E2F target gene whose expression can be directly regulated by E2F-1 via E2F binding sites in its promoter. In addition, expression of Topoisomerase IIalpha and subunit IV of DNA polymerase alpha is also up-regulated upon E2F-1 induction. Taken together, these results provide novel links between components of the DNA replication machinery and the cell growth regulatory pathway involving the Rb tumor suppressor and E2F.</description><subject>Antigens, Neoplasm</subject><subject>Base Sequence</subject><subject>Binding sites</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins</subject><subject>Cell cycle</subject><subject>Cell Cycle Proteins</subject><subject>Cell cycle, cell proliferation</subject><subject>Cell growth</subject><subject>Cell physiology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA biosynthesis</subject><subject>DNA microarrays</subject><subject>DNA polymerase</subject><subject>DNA Polymerase I - biosynthesis</subject><subject>DNA Replication - genetics</subject><subject>DNA Topoisomerases, Type II - biosynthesis</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-directed DNA polymerase</subject><subject>E2F protein</subject><subject>E2F Transcription Factors</subject><subject>E2F-1 protein</subject><subject>E2F1 protein</subject><subject>E2F1 Transcription Factor</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Profiling</subject><subject>Genes</subject><subject>Humans</subject><subject>Isoenzymes - biosynthesis</subject><subject>Kinases</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oligonucleotides</subject><subject>Promoter Regions, Genetic</subject><subject>Protein Subunits</subject><subject>Proteins</subject><subject>RB protein</subject><subject>Replication Protein A</subject><subject>Retinoblastoma-Binding Protein 1</subject><subject>Transcription Factor DP1</subject><subject>Transcription Factors - metabolism</subject><subject>Tumor suppressor genes</subject><subject>Tumors</subject><subject>Up-Regulation</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFksGO0zAQhiMEYsvClSOKQOKWMrbj2D5WSxeQVnCBs-U6dnGV2MWTSNvn4IVxl4qu0CLkg6XxN_-MZ_6qeklgSYDJd7hbpmiXhEJLGTyqFqQVXcO5ah9XC1AcGkUZvaieIe4AQCigT6sLQhhhUpJF9XN9u88OMaRYm2iGAwasZwxxW7__vKrHYHMyOZsD1r0bU8Qpm8lhPX03U72m1w2p532T3XYe7uLuLJf8nUR2-yFYMx1DWxcLE6Id5v5Y4v7bPqfJhViv6PPqiTcDuhen-7L6dr3-evWxufny4dPV6qaxnNCpkV0vuN-AksJL6qnwHljXgmud7KgS0BsjeL9RrZJWMQpKEdX1Ekq6B8PYZfX2t24p_WN2OOkxoHXDYKJLM2ohQPBW8P-CREguhSQFfPMXuEtzLmNFTbu2DL0F0hXq9T8pKhhwKeVZamsGp0P0qUzeHuvqFQVgqmwTCrV8gCqnLCvYFJ0PJf5QQtkrYnZe73MYTT5oAvroKI07XRylT44qCa9Ozc6b0fVn_GShe382aM3gs4k24B9OqU4oyX4BltTSBw</recordid><startdate>20010315</startdate><enddate>20010315</enddate><creator>KALMA, Yael</creator><creator>MARASH, Lea</creator><creator>LAMED, Yocheved</creator><creator>GINSBERG, Doron</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20010315</creationdate><title>Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2</title><author>KALMA, Yael ; MARASH, Lea ; LAMED, Yocheved ; GINSBERG, Doron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-86d75fb0987f82f27ff03640e4e862970daa75db9498c932099196d80c51f0a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antigens, Neoplasm</topic><topic>Base Sequence</topic><topic>Binding sites</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins</topic><topic>Cell cycle</topic><topic>Cell Cycle Proteins</topic><topic>Cell cycle, cell proliferation</topic><topic>Cell growth</topic><topic>Cell physiology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA biosynthesis</topic><topic>DNA microarrays</topic><topic>DNA polymerase</topic><topic>DNA Polymerase I - biosynthesis</topic><topic>DNA Replication - genetics</topic><topic>DNA Topoisomerases, Type II - biosynthesis</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-directed DNA polymerase</topic><topic>E2F protein</topic><topic>E2F Transcription Factors</topic><topic>E2F-1 protein</topic><topic>E2F1 protein</topic><topic>E2F1 Transcription Factor</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Profiling</topic><topic>Genes</topic><topic>Humans</topic><topic>Isoenzymes - biosynthesis</topic><topic>Kinases</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oligonucleotides</topic><topic>Promoter Regions, Genetic</topic><topic>Protein Subunits</topic><topic>Proteins</topic><topic>RB protein</topic><topic>Replication Protein A</topic><topic>Retinoblastoma-Binding Protein 1</topic><topic>Transcription Factor DP1</topic><topic>Transcription Factors - metabolism</topic><topic>Tumor suppressor genes</topic><topic>Tumors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KALMA, Yael</creatorcontrib><creatorcontrib>MARASH, Lea</creatorcontrib><creatorcontrib>LAMED, Yocheved</creatorcontrib><creatorcontrib>GINSBERG, Doron</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KALMA, Yael</au><au>MARASH, Lea</au><au>LAMED, Yocheved</au><au>GINSBERG, Doron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2</atitle><jtitle>Oncogene</jtitle><addtitle>Oncogene</addtitle><date>2001-03-15</date><risdate>2001</risdate><volume>20</volume><issue>11</issue><spage>1379</spage><epage>1387</epage><pages>1379-1387</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analysis to identify novel E2F target genes. We show that E2F-1 up-regulates the expression of a number of genes coding for components of the DNA replication machinery. Among them is the gene coding for the 32 Kd subunit of replication protein A (RPA2). Replication protein A is the most abundant single strand DNA binding complex and it is essential for DNA replication. We demonstrate that RPA2 is a novel E2F target gene whose expression can be directly regulated by E2F-1 via E2F binding sites in its promoter. In addition, expression of Topoisomerase IIalpha and subunit IV of DNA polymerase alpha is also up-regulated upon E2F-1 induction. Taken together, these results provide novel links between components of the DNA replication machinery and the cell growth regulatory pathway involving the Rb tumor suppressor and E2F.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>11313881</pmid><doi>10.1038/sj.onc.1204230</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0950-9232
ispartof Oncogene, 2001-03, Vol.20 (11), p.1379-1387
issn 0950-9232
1476-5594
language eng
recordid cdi_proquest_miscellaneous_77075475
source MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings
subjects Antigens, Neoplasm
Base Sequence
Binding sites
Biological and medical sciences
Carrier Proteins
Cell cycle
Cell Cycle Proteins
Cell cycle, cell proliferation
Cell growth
Cell physiology
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA microarrays
DNA polymerase
DNA Polymerase I - biosynthesis
DNA Replication - genetics
DNA Topoisomerases, Type II - biosynthesis
DNA-Binding Proteins - biosynthesis
DNA-Binding Proteins - genetics
DNA-directed DNA polymerase
E2F protein
E2F Transcription Factors
E2F-1 protein
E2F1 protein
E2F1 Transcription Factor
Fundamental and applied biological sciences. Psychology
Gene Expression Profiling
Genes
Humans
Isoenzymes - biosynthesis
Kinases
Molecular and cellular biology
Molecular Sequence Data
Oligonucleotide Array Sequence Analysis
Oligonucleotides
Promoter Regions, Genetic
Protein Subunits
Proteins
RB protein
Replication Protein A
Retinoblastoma-Binding Protein 1
Transcription Factor DP1
Transcription Factors - metabolism
Tumor suppressor genes
Tumors
Up-Regulation
title Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T09%3A09%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20analysis%20using%20DNA%20microarrays%20demonstrates%20that%20E2F-1%20up-regulates%20expression%20of%20DNA%20replication%20genes%20including%20replication%20protein%20A2&rft.jtitle=Oncogene&rft.au=KALMA,%20Yael&rft.date=2001-03-15&rft.volume=20&rft.issue=11&rft.spage=1379&rft.epage=1387&rft.pages=1379-1387&rft.issn=0950-9232&rft.eissn=1476-5594&rft.coden=ONCNES&rft_id=info:doi/10.1038/sj.onc.1204230&rft_dat=%3Cgale_proqu%3EA200390000%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=227305888&rft_id=info:pmid/11313881&rft_galeid=A200390000&rfr_iscdi=true