Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat

It has recently been proposed that primary mutations in genes involved in fatty acid and lipid metabolism may contribute to the pathogenesis of insulin resistance and dyslipidemia often observed in spontaneous forms of hypertension. In the current study in the spontaneously hypertensive rat (SHR), w...

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Veröffentlicht in:	Mammalian genome 2001-04, Vol.12 (4), p.295-298
Hauptverfasser:	Pravenec, Michal, Jansa, Petr, Kostka, Vlastimil, Zídek, Václav, Křen, Vladimír, Forejt, Jiří, Kurtz, Theodore W
Format:	Artikel
Sprache:	eng
Schlagworte:	ADD1 protein adipocyte determination and differentiation factor 1 adipocytes Amino Acid Sequence Animals biosynthesis Blood Pressure - genetics Blood Pressure - physiology carbohydrate metabolism CCAAT-Enhancer-Binding Proteins - genetics Cholesterol Cholesterol - blood chromosome 10 Chromosome Mapping chromosomes Crosses, Genetic DNA-Binding Proteins - genetics fatty acids gene expression Gene Transfer Techniques Genes Genetic Markers genetically modified organisms Genotype Heart Rate - genetics hyperlipidemia hypertension Hypertension - blood Hypertension - genetics insulin resistance lipid metabolism Lipoproteins - blood Metabolism Molecular Sequence Data mutants Mutation pathogenesis Phenotype quantitative trait loci Quantitative Trait, Heritable Rats Rats, Inbred SHR Rats, Inbred Strains regulator genes Rodents SREBP-1c protein Sterol Regulatory Element Binding Protein 1 sterol regulatory element binding protein 1c Transcription Factors transfection
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