An outbreak of multidrug resistant typhoid fever in Bangalore
Six hundred and eighty five blood cultures from children clinically diagnosed as enteric fever yielded 176 salmonella strains showing isolation success rate of 25.7%, S. typhi were 164 (93.2%), S. paratyphi A 5 (2.8%), S. choleraesuis 4 (2.3%) and S. typhimurium 3 (1.7%). Antibiogram of 164 isolates...
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| Veröffentlicht in: | Indian journal of pediatrics 1995-07, Vol.62 (4), p.445-448 |
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| creator | RATHISH, K. C CHANDRASHEKAR, M. R NAGESHA, C. N |
| description | Six hundred and eighty five blood cultures from children clinically diagnosed as enteric fever yielded 176 salmonella strains showing isolation success rate of 25.7%, S. typhi were 164 (93.2%), S. paratyphi A 5 (2.8%), S. choleraesuis 4 (2.3%) and S. typhimurium 3 (1.7%). Antibiogram of 164 isolates of S. typhi showed triple drug resistance (TDR) in 156 strains (95.1%) to chloramphenicol, ampicillin and cotrimoxazole, and sensitivity of 90.2% and 95.1% to norfloxacin and ciprofloxacin respectively. Minimum inhibitory concentrations (MIC) of chloramphenicol were between 360 mcg and 640 mcg per ml. Phage types of 38 strains of TDR S. typhi were predominantly E1 and 0 with prevalences of 47.4% and 36.8% respectively in this region. All children with S. typhi isolates sensitive to quinolones in Vitro responded well to these drugs with almost no relapse and hence, the newer generation of quinolones could be considered as the first choice in the primary treatment of enteric fever. |
| doi_str_mv | 10.1007/BF02755065 |
| format | Article |
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Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Disease Outbreaks</topic><topic>Drug Resistance, Multiple</topic><topic>Female</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Salmonella typhi - drug effects</topic><topic>Salmonella typhi - isolation & purification</topic><topic>Tropical medicine</topic><topic>Typhoid Fever - diagnosis</topic><topic>Typhoid Fever - drug therapy</topic><topic>Typhoid Fever - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RATHISH, K. C</creatorcontrib><creatorcontrib>CHANDRASHEKAR, M. R</creatorcontrib><creatorcontrib>NAGESHA, C. 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Minimum inhibitory concentrations (MIC) of chloramphenicol were between 360 mcg and 640 mcg per ml. Phage types of 38 strains of TDR S. typhi were predominantly E1 and 0 with prevalences of 47.4% and 36.8% respectively in this region. All children with S. typhi isolates sensitive to quinolones in Vitro responded well to these drugs with almost no relapse and hence, the newer generation of quinolones could be considered as the first choice in the primary treatment of enteric fever.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>10829903</pmid><doi>10.1007/BF02755065</doi><tpages>4</tpages></addata></record> |
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| ispartof | Indian journal of pediatrics, 1995-07, Vol.62 (4), p.445-448 |
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| subjects | Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Child Child, Preschool Disease Outbreaks Drug Resistance, Multiple Female Humans India - epidemiology Male Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Salmonella typhi - drug effects Salmonella typhi - isolation & purification Tropical medicine Typhoid Fever - diagnosis Typhoid Fever - drug therapy Typhoid Fever - epidemiology |
| title | An outbreak of multidrug resistant typhoid fever in Bangalore |
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