Carbamylcholine, but not somatostatin or neurotensin, stimulates prostaglandin E2 release from the isolated perfused rat stomach
Prostaglandin E2 release by carbamylcholine (10(-6) M), somatostatin (10(-10)-10(-8) M) and neurotensin (10(-10) - 10(-8) M) has been evaluated in the isolated perfused rat stomach. Carbamylcholine significantly stimulated gastric PGE2 release and increased the perfusion pressure, whereas somatostat...
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| Veröffentlicht in: | Regulatory peptides 1986-08, Vol.15 (1), p.71-76 |
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| container_title | Regulatory peptides |
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| creator | MOGARD, M. H KAUFFMAN, G. L. JR PEHLEVANIAN, M REEDY, T. J ELASHOFF, J. D WALSH, J. H |
| description | Prostaglandin E2 release by carbamylcholine (10(-6) M), somatostatin (10(-10)-10(-8) M) and neurotensin (10(-10) - 10(-8) M) has been evaluated in the isolated perfused rat stomach. Carbamylcholine significantly stimulated gastric PGE2 release and increased the perfusion pressure, whereas somatostatin and neurotensin had no effect. Combination of carbamylcholine with somatostatin or neurotensin produced no increase over that found with carbamylcholine alone. The relationship between perfusion-pressure and PGE2 release was not causal. The present findings do not support a role for prostaglandins in the mechanism of somatostatin or neurotensin action in the stomach. |
| doi_str_mv | 10.1016/0167-0115(86)90077-7 |
| format | Article |
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H ; KAUFFMAN, G. L. JR ; PEHLEVANIAN, M ; REEDY, T. J ; ELASHOFF, J. D ; WALSH, J. H</creator><creatorcontrib>MOGARD, M. H ; KAUFFMAN, G. L. JR ; PEHLEVANIAN, M ; REEDY, T. J ; ELASHOFF, J. D ; WALSH, J. H</creatorcontrib><description>Prostaglandin E2 release by carbamylcholine (10(-6) M), somatostatin (10(-10)-10(-8) M) and neurotensin (10(-10) - 10(-8) M) has been evaluated in the isolated perfused rat stomach. Carbamylcholine significantly stimulated gastric PGE2 release and increased the perfusion pressure, whereas somatostatin and neurotensin had no effect. Combination of carbamylcholine with somatostatin or neurotensin produced no increase over that found with carbamylcholine alone. The relationship between perfusion-pressure and PGE2 release was not causal. The present findings do not support a role for prostaglandins in the mechanism of somatostatin or neurotensin action in the stomach.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(86)90077-7</identifier><identifier>PMID: 2876462</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Animals ; Biological and medical sciences ; Carbachol - pharmacology ; Dinoprostone ; Fundamental and applied biological sciences. Psychology ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; In Vitro Techniques ; Kinetics ; Neurotensin - pharmacology ; Prostaglandins E - metabolism ; Prostaglandins. 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H</creatorcontrib><creatorcontrib>KAUFFMAN, G. L. JR</creatorcontrib><creatorcontrib>PEHLEVANIAN, M</creatorcontrib><creatorcontrib>REEDY, T. J</creatorcontrib><creatorcontrib>ELASHOFF, J. D</creatorcontrib><creatorcontrib>WALSH, J. H</creatorcontrib><title>Carbamylcholine, but not somatostatin or neurotensin, stimulates prostaglandin E2 release from the isolated perfused rat stomach</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>Prostaglandin E2 release by carbamylcholine (10(-6) M), somatostatin (10(-10)-10(-8) M) and neurotensin (10(-10) - 10(-8) M) has been evaluated in the isolated perfused rat stomach. Carbamylcholine significantly stimulated gastric PGE2 release and increased the perfusion pressure, whereas somatostatin and neurotensin had no effect. Combination of carbamylcholine with somatostatin or neurotensin produced no increase over that found with carbamylcholine alone. The relationship between perfusion-pressure and PGE2 release was not causal. The present findings do not support a role for prostaglandins in the mechanism of somatostatin or neurotensin action in the stomach.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbachol - pharmacology</subject><subject>Dinoprostone</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Neurotensin - pharmacology</subject><subject>Prostaglandins E - metabolism</subject><subject>Prostaglandins. Arachidonic acid metabolites</subject><subject>Rats</subject><subject>Somatostatin - pharmacology</subject><subject>Vertebrates: endocrinology</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFr3DAQhUVpSTdp_0EKOpSQQtxKsi3Jx7AkaSHQS3sWY-0o62JbW418yK0_vXKy7EGM4H3z9PQYu5TiqxRSfyvHVELK9trqL50QxlTmDdtIa-pKaqvfss0Jec_Oif4IIVtj6jN2pqzRjVYb9m8LqYfpefT7OA4z3vB-yXyOmVOcIEfKkIeZx8RnXFLMONMw33DKw7SMkJH4Ia3Q0wjzroB3iiccEQh5SHHieY98oLiiO37AFBYqlwTFP5cH_P4DexdgJPx4nBfs9_3dr-336vHnw4_t7WPl61rmqgPVqAYbKXr0iK22CrzoTd8JULoDretW914XNWjRCKE7EVC3oVeogjb1Bbt69S15_y5I2U0DeRxLbowLOWOEKRa2gM0r6MvHKGFwhzRMkJ6dFG4t3q2turVVZ7V7Kd6t_p-O_ks_4e60dGy66J-POpCHMSSY_UAnzFqp6hLzP4dgjdk</recordid><startdate>19860801</startdate><enddate>19860801</enddate><creator>MOGARD, M. H</creator><creator>KAUFFMAN, G. L. 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H</creatorcontrib><creatorcontrib>KAUFFMAN, G. L. JR</creatorcontrib><creatorcontrib>PEHLEVANIAN, M</creatorcontrib><creatorcontrib>REEDY, T. J</creatorcontrib><creatorcontrib>ELASHOFF, J. D</creatorcontrib><creatorcontrib>WALSH, J. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOGARD, M. H</au><au>KAUFFMAN, G. L. JR</au><au>PEHLEVANIAN, M</au><au>REEDY, T. J</au><au>ELASHOFF, J. D</au><au>WALSH, J. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbamylcholine, but not somatostatin or neurotensin, stimulates prostaglandin E2 release from the isolated perfused rat stomach</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1986-08-01</date><risdate>1986</risdate><volume>15</volume><issue>1</issue><spage>71</spage><epage>76</epage><pages>71-76</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>Prostaglandin E2 release by carbamylcholine (10(-6) M), somatostatin (10(-10)-10(-8) M) and neurotensin (10(-10) - 10(-8) M) has been evaluated in the isolated perfused rat stomach. Carbamylcholine significantly stimulated gastric PGE2 release and increased the perfusion pressure, whereas somatostatin and neurotensin had no effect. Combination of carbamylcholine with somatostatin or neurotensin produced no increase over that found with carbamylcholine alone. The relationship between perfusion-pressure and PGE2 release was not causal. The present findings do not support a role for prostaglandins in the mechanism of somatostatin or neurotensin action in the stomach.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>2876462</pmid><doi>10.1016/0167-0115(86)90077-7</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0167-0115 |
| ispartof | Regulatory peptides, 1986-08, Vol.15 (1), p.71-76 |
| issn | 0167-0115 1873-1686 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Carbachol - pharmacology Dinoprostone Fundamental and applied biological sciences. Psychology Gastric Mucosa - drug effects Gastric Mucosa - metabolism In Vitro Techniques Kinetics Neurotensin - pharmacology Prostaglandins E - metabolism Prostaglandins. Arachidonic acid metabolites Rats Somatostatin - pharmacology Vertebrates: endocrinology |
| title | Carbamylcholine, but not somatostatin or neurotensin, stimulates prostaglandin E2 release from the isolated perfused rat stomach |
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