Engineering of macrophages to produce IFN-gamma in response to hypoxia

Activation of murine macrophages (Mphi) requires the collaboration of signals derived from the immune system and the environment. In this study, we engineered a murine Mphi cell line to become activated in response to an environmental signal, hypoxia, as the sole stimulus. Hypoxia is a condition of...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-05, Vol.166 (9), p.5374-5380
Hauptverfasser:	Carta, L, Pastorino, S, Melillo, G, Bosco, M C, Massazza, S, Varesio, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques - methods Cell Hypoxia - genetics Cell Hypoxia - immunology Cell Line Chemokine CCL4 Clone Cells Gene Expression Regulation - immunology Genetic Vectors - chemical synthesis Genetic Vectors - immunology Histocompatibility Antigens Class II - biosynthesis Histocompatibility Antigens Class II - genetics Interferon-gamma - biosynthesis Interferon-gamma - genetics Interferon-gamma - physiology Macrophage Activation - genetics Macrophage Inflammatory Proteins - biosynthesis Macrophage Inflammatory Proteins - genetics Macrophages - enzymology Macrophages - immunology Macrophages - metabolism Macrophages - physiology Mice Mice, Inbred C57BL Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Receptors, IgG - biosynthesis Receptors, IgG - genetics Response Elements - immunology RNA, Messenger - biosynthesis Transfection
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