Long-range intermolecular interaction between broken DNA fragments
We analyzed the long-range intermolecular interaction between fragments of broken DNA. We considered two constituents of long-range intermolecular interaction. The first is a net electrostatic Coulomb interaction between charges, involved in a structure of opposite nucleotides, which we evaluate usi...
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| Veröffentlicht in: | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics Statistical physics, plasmas, fluids, and related interdisciplinary topics, 2001-03, Vol.63 (3 Pt 1), p.031904-0319046, Article 031904 |
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| container_end_page | 0319046 |
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| container_issue | 3 Pt 1 |
| container_start_page | 031904 |
| container_title | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics |
| container_volume | 63 |
| creator | Pinchuk, A O Vysotskii, V I |
| description | We analyzed the long-range intermolecular interaction between fragments of broken DNA. We considered two constituents of long-range intermolecular interaction. The first is a net electrostatic Coulomb interaction between charges, involved in a structure of opposite nucleotides, which we evaluate using Debye-Huckel theory. The second one is the Van der Waals interaction between the nucleotides. The general Lifshitz theory of Van der Waals forces was used to evaluate this interaction. Numerical calculations showed that a repulsive force between broken DNA fragments can arise in specific cases. This repulsion can prevent DNA from repairing itself after a double-strand break. The height of the barrier decreases with an increase of the ionic strength of the intracellular milieu, or with a reduction of its viscosity. |
| doi_str_mv | 10.1103/PhysRevE.63.031904 |
| format | Article |
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We considered two constituents of long-range intermolecular interaction. The first is a net electrostatic Coulomb interaction between charges, involved in a structure of opposite nucleotides, which we evaluate using Debye-Huckel theory. The second one is the Van der Waals interaction between the nucleotides. The general Lifshitz theory of Van der Waals forces was used to evaluate this interaction. Numerical calculations showed that a repulsive force between broken DNA fragments can arise in specific cases. This repulsion can prevent DNA from repairing itself after a double-strand break. 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The height of the barrier decreases with an increase of the ionic strength of the intracellular milieu, or with a reduction of its viscosity.</description><subject>Base Pairing</subject><subject>Binding Sites</subject><subject>Computer Simulation</subject><subject>DNA - chemistry</subject><subject>DNA Damage</subject><subject>DNA Fragmentation</subject><subject>DNA Repair</subject><subject>Electrodynamics</subject><subject>Electrostatics</subject><subject>Energy Transfer</subject><subject>Enzymes</subject><subject>Ionic strength</subject><subject>Macromolecular Substances</subject><subject>Models, Chemical</subject><subject>Models, Molecular</subject><subject>Molecular structure</subject><subject>Nucleic Acid Conformation</subject><subject>Nucleotides - chemistry</subject><subject>Permittivity</subject><subject>Poisson equation</subject><subject>Static Electricity</subject><subject>Van der Waals forces</subject><subject>Viscosity</subject><issn>1539-3755</issn><issn>1063-651X</issn><issn>1095-3787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EoqXwBzignril7GbtxDmWUh5SBQjB2XJcuxTyKHYC6r8nKEUcOc3s7uwcPsZOESaIQBePr9vwZD_nk4QmQJgB32NDhExElMp0v_OCss4LMWBHIbwBUEySH7IBIoFMUjFkl4u6WkVeVys7XleN9WVdWNMW2vejNs26rsa5bb6s7dTX751c3U_HzutVaasmHLMDp4tgT3Y6Yi_X8-fZbbR4uLmbTReRIYImypIcUpNJuUSTISSAyLWmTDsymKDI4xyclE6KPOfcJSZ23ZWIup0R3NKInfe9G19_tDY0qlwHY4tCV7Zug0pTSBFS8W8wRs5REnTBuA8aX4fgrVMbvy613yoE9YNY_SJWCakecfd0tmtv89Iu_152TOkbs9Z4eA</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Pinchuk, A O</creator><creator>Vysotskii, V I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Long-range intermolecular interaction between broken DNA fragments</title><author>Pinchuk, A O ; Vysotskii, V I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-96b07c988d1c91060114aa39af3c1615b2b0f88f85bb44f6c2fa3933388fc54e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Base Pairing</topic><topic>Binding Sites</topic><topic>Computer Simulation</topic><topic>DNA - chemistry</topic><topic>DNA Damage</topic><topic>DNA Fragmentation</topic><topic>DNA Repair</topic><topic>Electrodynamics</topic><topic>Electrostatics</topic><topic>Energy Transfer</topic><topic>Enzymes</topic><topic>Ionic strength</topic><topic>Macromolecular Substances</topic><topic>Models, Chemical</topic><topic>Models, Molecular</topic><topic>Molecular structure</topic><topic>Nucleic Acid Conformation</topic><topic>Nucleotides - chemistry</topic><topic>Permittivity</topic><topic>Poisson equation</topic><topic>Static Electricity</topic><topic>Van der Waals forces</topic><topic>Viscosity</topic><toplevel>online_resources</toplevel><creatorcontrib>Pinchuk, A O</creatorcontrib><creatorcontrib>Vysotskii, V I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physical review. 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| ispartof | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 2001-03, Vol.63 (3 Pt 1), p.031904-0319046, Article 031904 |
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| language | eng |
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| source | MEDLINE; American Physical Society Journals |
| subjects | Base Pairing Binding Sites Computer Simulation DNA - chemistry DNA Damage DNA Fragmentation DNA Repair Electrodynamics Electrostatics Energy Transfer Enzymes Ionic strength Macromolecular Substances Models, Chemical Models, Molecular Molecular structure Nucleic Acid Conformation Nucleotides - chemistry Permittivity Poisson equation Static Electricity Van der Waals forces Viscosity |
| title | Long-range intermolecular interaction between broken DNA fragments |
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