Metabolism and Distribution of [2,3-14C]Acrolein in Lactating Goats
The metabolism and distribution of [2,3-14C]acrolein were studied in a lactating goat orally administered 0.82 mg/kg of body weight/day for 5 days. Milk, urine, feces, and expired air were collected. The goat was killed 12 h after the last dose, and edible tissues were collected. The nature of the r...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2001-03, Vol.49 (3), p.1630-1638 |
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| container_issue | 3 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 49 |
| creator | Sharp, Dale E Berge, Milan A Paust, Douglas E Talaat, Rasmy E Wilkes, Laurie C Servatius, Laura J Loftus, Michele L Caravello, Halina E Parent, Richard A |
| description | The metabolism and distribution of [2,3-14C]acrolein were studied in a lactating goat orally administered 0.82 mg/kg of body weight/day for 5 days. Milk, urine, feces, and expired air were collected. The goat was killed 12 h after the last dose, and edible tissues were collected. The nature of the radioactive residues was determined in milk and tissues. All of the identified metabolites were the result of the incorporation of acrolein into the normal, natural products of intermediary metabolism. There was evidence that the three-carbon unit of acrolein was incorporated intact into glucose, and subsequently lactose, and into glycerol. In the case of other natural products, the incorporation of radioactivity appeared to result from the metabolism of acrolein to smaller molecules followed by incorporation of these metabolites into the normal biosynthetic pathways. Keywords: Metabolism; acrolein; goat |
| doi_str_mv | 10.1021/jf000078z |
| format | Article |
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Milk, urine, feces, and expired air were collected. The goat was killed 12 h after the last dose, and edible tissues were collected. The nature of the radioactive residues was determined in milk and tissues. All of the identified metabolites were the result of the incorporation of acrolein into the normal, natural products of intermediary metabolism. There was evidence that the three-carbon unit of acrolein was incorporated intact into glucose, and subsequently lactose, and into glycerol. In the case of other natural products, the incorporation of radioactivity appeared to result from the metabolism of acrolein to smaller molecules followed by incorporation of these metabolites into the normal biosynthetic pathways. 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Psychology ; Goats ; Lactation - physiology ; Milk - chemistry ; Tissue Distribution</subject><ispartof>Journal of agricultural and food chemistry, 2001-03, Vol.49 (3), p.1630-1638</ispartof><rights>Copyright © 2001 American Chemical Society</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a368t-e05205e6052f092bd743f7b5a36452eb35d3b1b141282ee5ed34a6b54a34abbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf000078z$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf000078z$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=939673$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11312907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharp, Dale E</creatorcontrib><creatorcontrib>Berge, Milan A</creatorcontrib><creatorcontrib>Paust, Douglas E</creatorcontrib><creatorcontrib>Talaat, Rasmy E</creatorcontrib><creatorcontrib>Wilkes, Laurie C</creatorcontrib><creatorcontrib>Servatius, Laura J</creatorcontrib><creatorcontrib>Loftus, Michele L</creatorcontrib><creatorcontrib>Caravello, Halina E</creatorcontrib><creatorcontrib>Parent, Richard A</creatorcontrib><title>Metabolism and Distribution of [2,3-14C]Acrolein in Lactating Goats</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>The metabolism and distribution of [2,3-14C]acrolein were studied in a lactating goat orally administered 0.82 mg/kg of body weight/day for 5 days. Milk, urine, feces, and expired air were collected. The goat was killed 12 h after the last dose, and edible tissues were collected. The nature of the radioactive residues was determined in milk and tissues. All of the identified metabolites were the result of the incorporation of acrolein into the normal, natural products of intermediary metabolism. There was evidence that the three-carbon unit of acrolein was incorporated intact into glucose, and subsequently lactose, and into glycerol. In the case of other natural products, the incorporation of radioactivity appeared to result from the metabolism of acrolein to smaller molecules followed by incorporation of these metabolites into the normal biosynthetic pathways. Keywords: Metabolism; acrolein; goat</description><subject>Acrolein - administration & dosage</subject><subject>Acrolein - blood</subject><subject>Acrolein - pharmacokinetics</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biotransformation</subject><subject>Breath Tests</subject><subject>Carbon Radioisotopes</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Food industries</subject><subject>Food toxicology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Goats</subject><subject>Lactation - physiology</subject><subject>Milk - chemistry</subject><subject>Tissue Distribution</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0NFKwzAUBuAgipvTC19ACqIgWM1Jmia7HJtOYaLivBIJSZtKZtfOpAX16c3YmDeCIXAu_o9D8iN0CPgCMIHLWYHD4eJ7C3WBERwzALGNujiEsWApdNCe97NgBON4F3UAKJA-5l00vDON0nVp_TxSVR6NrG-c1W1j6yqqi-iFnNMYkuHrIHN1aWwVhTtRWaMaW71F41o1fh_tFKr05mA9e-j5-mo6vIkn9-Pb4WASK5qKJjY4PI2ZNIwC94nOeUILrllIE0aMpiynGjQkQAQxhpmcJirVLFFhap3THjpd7V24-qM1vpFz6zNTlqoydesl55hjgeFfCCLBgvA0wLMVDJ_z3plCLpydK_clActltXJTbbBH66Wtnpv8V667DOB4DZTPVFk4VWXWb1yf9lNOg4pXKhRtPjepcu8yxJzJ6cOTpI8jYBM8lkt_svIq83JWt64KFf_xvB95OZhz</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Sharp, Dale E</creator><creator>Berge, Milan A</creator><creator>Paust, Douglas E</creator><creator>Talaat, Rasmy E</creator><creator>Wilkes, Laurie C</creator><creator>Servatius, Laura J</creator><creator>Loftus, Michele L</creator><creator>Caravello, Halina E</creator><creator>Parent, Richard A</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Metabolism and Distribution of [2,3-14C]Acrolein in Lactating Goats</title><author>Sharp, Dale E ; Berge, Milan A ; Paust, Douglas E ; Talaat, Rasmy E ; Wilkes, Laurie C ; Servatius, Laura J ; Loftus, Michele L ; Caravello, Halina E ; Parent, Richard A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a368t-e05205e6052f092bd743f7b5a36452eb35d3b1b141282ee5ed34a6b54a34abbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acrolein - administration & dosage</topic><topic>Acrolein - blood</topic><topic>Acrolein - pharmacokinetics</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biotransformation</topic><topic>Breath Tests</topic><topic>Carbon Radioisotopes</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Food industries</topic><topic>Food toxicology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Goats</topic><topic>Lactation - physiology</topic><topic>Milk - chemistry</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharp, Dale E</creatorcontrib><creatorcontrib>Berge, Milan A</creatorcontrib><creatorcontrib>Paust, Douglas E</creatorcontrib><creatorcontrib>Talaat, Rasmy E</creatorcontrib><creatorcontrib>Wilkes, Laurie C</creatorcontrib><creatorcontrib>Servatius, Laura J</creatorcontrib><creatorcontrib>Loftus, Michele L</creatorcontrib><creatorcontrib>Caravello, Halina E</creatorcontrib><creatorcontrib>Parent, Richard A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharp, Dale E</au><au>Berge, Milan A</au><au>Paust, Douglas E</au><au>Talaat, Rasmy E</au><au>Wilkes, Laurie C</au><au>Servatius, Laura J</au><au>Loftus, Michele L</au><au>Caravello, Halina E</au><au>Parent, Richard A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism and Distribution of [2,3-14C]Acrolein in Lactating Goats</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>49</volume><issue>3</issue><spage>1630</spage><epage>1638</epage><pages>1630-1638</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>The metabolism and distribution of [2,3-14C]acrolein were studied in a lactating goat orally administered 0.82 mg/kg of body weight/day for 5 days. Milk, urine, feces, and expired air were collected. The goat was killed 12 h after the last dose, and edible tissues were collected. The nature of the radioactive residues was determined in milk and tissues. All of the identified metabolites were the result of the incorporation of acrolein into the normal, natural products of intermediary metabolism. There was evidence that the three-carbon unit of acrolein was incorporated intact into glucose, and subsequently lactose, and into glycerol. In the case of other natural products, the incorporation of radioactivity appeared to result from the metabolism of acrolein to smaller molecules followed by incorporation of these metabolites into the normal biosynthetic pathways. Keywords: Metabolism; acrolein; goat</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>11312907</pmid><doi>10.1021/jf000078z</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Acrolein - administration & dosage Acrolein - blood Acrolein - pharmacokinetics Administration, Oral Animals Biological and medical sciences Biotransformation Breath Tests Carbon Radioisotopes Feces - chemistry Female Food industries Food toxicology Fundamental and applied biological sciences. Psychology Goats Lactation - physiology Milk - chemistry Tissue Distribution |
| title | Metabolism and Distribution of [2,3-14C]Acrolein in Lactating Goats |
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