Met-enkephalin-induced release into the blood of a factor causing postural asymmetry

Met- and Leu-enkephalin applied subarachnoidally into the rostral portion of a transected spinal cord (at the T6-T7 level) induce postural asymmetry of the hind limbs in rats, Met-enkephalin being predominantly responsible for the flexion of the right, and Leu-enkephalin of the left, hind leg. The b...

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Veröffentlicht in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1986-07, Vol.7 (4), p.551-556
Hauptverfasser: Bakalkin, G.Ya, Kobylyansky, A.G., Nagornaya, L.V., Yarygin, K.N., Titov, M.I.
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container_end_page 556
container_issue 4
container_start_page 551
container_title Peptides (New York, N.Y. : 1980)
container_volume 7
creator Bakalkin, G.Ya
Kobylyansky, A.G.
Nagornaya, L.V.
Yarygin, K.N.
Titov, M.I.
description Met- and Leu-enkephalin applied subarachnoidally into the rostral portion of a transected spinal cord (at the T6-T7 level) induce postural asymmetry of the hind limbs in rats, Met-enkephalin being predominantly responsible for the flexion of the right, and Leu-enkephalin of the left, hind leg. The blood serum of rats injected with Met-enkephalin contains a factor which, when administered subarachnoidally into the caudal portion of the transected spinal cord, is capable of inducing the hind limb postural asymmetry—predominantly, with the right leg flexion. This factor is inactivated by papain and differs from Met- and Leu-enkephalin in chromatographic properties. Apparently, Met-enkephalin induces the release of a peptide factor into the blood, from the brain or organs innervated by the neurons lying above the cut. It is then carried with the blood to the hind limbs and effects the hind limb postural asymmetry.
doi_str_mv 10.1016/0196-9781(86)90025-2
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Animals
Biological and medical sciences
Blood Proteins - isolation & purification
Blood Proteins - physiology
Enkephalin, Leucine - pharmacology
Enkephalin, Methionine - pharmacology
Enkephalins
Fundamental and applied biological sciences. Psychology
Hind limb postural asymmetry
Left/right flexion ratio
Male
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Naloxone - pharmacology
Posture
Rats
Rats, Inbred Strains
Spinal Cord - physiology
Vertebrates: nervous system and sense organs
title Met-enkephalin-induced release into the blood of a factor causing postural asymmetry
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