Met-enkephalin-induced release into the blood of a factor causing postural asymmetry
Met- and Leu-enkephalin applied subarachnoidally into the rostral portion of a transected spinal cord (at the T6-T7 level) induce postural asymmetry of the hind limbs in rats, Met-enkephalin being predominantly responsible for the flexion of the right, and Leu-enkephalin of the left, hind leg. The b...
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Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1986-07, Vol.7 (4), p.551-556 |
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container_title | Peptides (New York, N.Y. : 1980) |
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creator | Bakalkin, G.Ya Kobylyansky, A.G. Nagornaya, L.V. Yarygin, K.N. Titov, M.I. |
description | Met- and Leu-enkephalin applied subarachnoidally into the rostral portion of a transected spinal cord (at the T6-T7 level) induce postural asymmetry of the hind limbs in rats, Met-enkephalin being predominantly responsible for the flexion of the right, and Leu-enkephalin of the left, hind leg. The blood serum of rats injected with Met-enkephalin contains a factor which, when administered subarachnoidally into the caudal portion of the transected spinal cord, is capable of inducing the hind limb postural asymmetry—predominantly, with the right leg flexion. This factor is inactivated by papain and differs from Met- and Leu-enkephalin in chromatographic properties. Apparently, Met-enkephalin induces the release of a peptide factor into the blood, from the brain or organs innervated by the neurons lying above the cut. It is then carried with the blood to the hind limbs and effects the hind limb postural asymmetry. |
doi_str_mv | 10.1016/0196-9781(86)90025-2 |
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The blood serum of rats injected with Met-enkephalin contains a factor which, when administered subarachnoidally into the caudal portion of the transected spinal cord, is capable of inducing the hind limb postural asymmetry—predominantly, with the right leg flexion. This factor is inactivated by papain and differs from Met- and Leu-enkephalin in chromatographic properties. Apparently, Met-enkephalin induces the release of a peptide factor into the blood, from the brain or organs innervated by the neurons lying above the cut. It is then carried with the blood to the hind limbs and effects the hind limb postural asymmetry.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(86)90025-2</identifier><identifier>PMID: 3763433</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Proteins - isolation & purification ; Blood Proteins - physiology ; Enkephalin, Leucine - pharmacology ; Enkephalin, Methionine - pharmacology ; Enkephalins ; Fundamental and applied biological sciences. Psychology ; Hind limb postural asymmetry ; Left/right flexion ratio ; Male ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Naloxone - pharmacology ; Posture ; Rats ; Rats, Inbred Strains ; Spinal Cord - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Peptides (New York, N.Y. : 1980), 1986-07, Vol.7 (4), p.551-556</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-3e8d1fd3e5fadf2ce7f65b24b891548be1c4445a14713240623442e5101d8d9f3</citedby><cites>FETCH-LOGICAL-c417t-3e8d1fd3e5fadf2ce7f65b24b891548be1c4445a14713240623442e5101d8d9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(86)90025-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8131752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3763433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakalkin, G.Ya</creatorcontrib><creatorcontrib>Kobylyansky, A.G.</creatorcontrib><creatorcontrib>Nagornaya, L.V.</creatorcontrib><creatorcontrib>Yarygin, K.N.</creatorcontrib><creatorcontrib>Titov, M.I.</creatorcontrib><title>Met-enkephalin-induced release into the blood of a factor causing postural asymmetry</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Met- and Leu-enkephalin applied subarachnoidally into the rostral portion of a transected spinal cord (at the T6-T7 level) induce postural asymmetry of the hind limbs in rats, Met-enkephalin being predominantly responsible for the flexion of the right, and Leu-enkephalin of the left, hind leg. The blood serum of rats injected with Met-enkephalin contains a factor which, when administered subarachnoidally into the caudal portion of the transected spinal cord, is capable of inducing the hind limb postural asymmetry—predominantly, with the right leg flexion. This factor is inactivated by papain and differs from Met- and Leu-enkephalin in chromatographic properties. Apparently, Met-enkephalin induces the release of a peptide factor into the blood, from the brain or organs innervated by the neurons lying above the cut. It is then carried with the blood to the hind limbs and effects the hind limb postural asymmetry.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - isolation & purification</subject><subject>Blood Proteins - physiology</subject><subject>Enkephalin, Leucine - pharmacology</subject><subject>Enkephalin, Methionine - pharmacology</subject><subject>Enkephalins</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hind limb postural asymmetry</subject><subject>Left/right flexion ratio</subject><subject>Male</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Naloxone - pharmacology</subject><subject>Posture</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Spinal Cord - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKtvCPwDJB4TKIeCJHdu5VEIVX1IRl3K2HHtMDUm82A7S_nsS7WqPcJrDPPNq5hlCXgB7CwzkOwa9bHql4VrLNz1jbde0j8gOtOJNB7J_THZn5Cm5LOUnY0yIXl-QC64kF5zvyP1XrA3Ov3D_YMc4N3H2i0NPM45oC9I410TrA9JhTMnTFKilwbqaMnV2KXH-Qfep1CXbkdpymCas-fCMPAl2LPj8VK_I948f7m8_N3ffPn25fX_XOAGqNhy1h-A5dsH60DpUQXZDKwbdQyf0gOCEEJ0FoYC3gsmWC9Fit17vte8DvyKvj7n7nH4vWKqZYnE4jnbGtBSjFJM9SP1fEITsQGu2guIIupxKyRjMPsfJ5oMBZjbrZlNqNqVGr3Wzbtp17OUpfxkm9Oehk-a1_-rUt8XZMWQ7u1jOmAYOqttibo4YrtL-RMymuIjz-o-Y0VXjU_z3Hn8B0iOdZw</recordid><startdate>19860701</startdate><enddate>19860701</enddate><creator>Bakalkin, G.Ya</creator><creator>Kobylyansky, A.G.</creator><creator>Nagornaya, L.V.</creator><creator>Yarygin, K.N.</creator><creator>Titov, M.I.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19860701</creationdate><title>Met-enkephalin-induced release into the blood of a factor causing postural asymmetry</title><author>Bakalkin, G.Ya ; Kobylyansky, A.G. ; Nagornaya, L.V. ; Yarygin, K.N. ; Titov, M.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3e8d1fd3e5fadf2ce7f65b24b891548be1c4445a14713240623442e5101d8d9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - isolation & purification</topic><topic>Blood Proteins - physiology</topic><topic>Enkephalin, Leucine - pharmacology</topic><topic>Enkephalin, Methionine - pharmacology</topic><topic>Enkephalins</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hind limb postural asymmetry</topic><topic>Left/right flexion ratio</topic><topic>Male</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Naloxone - pharmacology</topic><topic>Posture</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Spinal Cord - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakalkin, G.Ya</creatorcontrib><creatorcontrib>Kobylyansky, A.G.</creatorcontrib><creatorcontrib>Nagornaya, L.V.</creatorcontrib><creatorcontrib>Yarygin, K.N.</creatorcontrib><creatorcontrib>Titov, M.I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakalkin, G.Ya</au><au>Kobylyansky, A.G.</au><au>Nagornaya, L.V.</au><au>Yarygin, K.N.</au><au>Titov, M.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Met-enkephalin-induced release into the blood of a factor causing postural asymmetry</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1986-07-01</date><risdate>1986</risdate><volume>7</volume><issue>4</issue><spage>551</spage><epage>556</epage><pages>551-556</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Met- and Leu-enkephalin applied subarachnoidally into the rostral portion of a transected spinal cord (at the T6-T7 level) induce postural asymmetry of the hind limbs in rats, Met-enkephalin being predominantly responsible for the flexion of the right, and Leu-enkephalin of the left, hind leg. The blood serum of rats injected with Met-enkephalin contains a factor which, when administered subarachnoidally into the caudal portion of the transected spinal cord, is capable of inducing the hind limb postural asymmetry—predominantly, with the right leg flexion. This factor is inactivated by papain and differs from Met- and Leu-enkephalin in chromatographic properties. Apparently, Met-enkephalin induces the release of a peptide factor into the blood, from the brain or organs innervated by the neurons lying above the cut. It is then carried with the blood to the hind limbs and effects the hind limb postural asymmetry.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3763433</pmid><doi>10.1016/0196-9781(86)90025-2</doi><tpages>6</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Blood Proteins - isolation & purification Blood Proteins - physiology Enkephalin, Leucine - pharmacology Enkephalin, Methionine - pharmacology Enkephalins Fundamental and applied biological sciences. Psychology Hind limb postural asymmetry Left/right flexion ratio Male Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Naloxone - pharmacology Posture Rats Rats, Inbred Strains Spinal Cord - physiology Vertebrates: nervous system and sense organs |
title | Met-enkephalin-induced release into the blood of a factor causing postural asymmetry |
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