Oxytocinase Activity in Human Amniotic Fluid and Its Relationship to Gestational Age
Oxytocinase (EC 3.4.11.3) activity in amniotic fluid samples obtained from 200 normal pregnant women (mean age, 28 years) between 14 and 40 weeks of gestation and during active labor was assayed using S-benzyl-L-cysteine-p-nitroanilide (BCN) and L-leucine-p-nitroanilide (LN) separately as substrates...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1986-11, Vol.68 (5), p.614-618 |
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| container_end_page | 618 |
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| container_issue | 5 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
| container_volume | 68 |
| creator | ROY, ASHIM C KOTTEGODA, SRI R VIEGAS, OSBORN A. C RATNAM, SHAN S |
| description | Oxytocinase (EC 3.4.11.3) activity in amniotic fluid samples obtained from 200 normal pregnant women (mean age, 28 years) between 14 and 40 weeks of gestation and during active labor was assayed using S-benzyl-L-cysteine-p-nitroanilide (BCN) and L-leucine-p-nitroanilide (LN) separately as substrates. With both substrates, amniotic fluid oxytocinase activity correlated inversely with gestational age; the level of the enzyme, which was highest in early pregnancy, decreased exponentially to a minimum near term and during labor. However, whether oxytocinase activity in the amniotic fluid is of any significance for the maintenance and/or termination of pregnancy remains to be established. |
| format | Article |
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C ; RATNAM, SHAN S</creator><creatorcontrib>ROY, ASHIM C ; KOTTEGODA, SRI R ; VIEGAS, OSBORN A. C ; RATNAM, SHAN S</creatorcontrib><description>Oxytocinase (EC 3.4.11.3) activity in amniotic fluid samples obtained from 200 normal pregnant women (mean age, 28 years) between 14 and 40 weeks of gestation and during active labor was assayed using S-benzyl-L-cysteine-p-nitroanilide (BCN) and L-leucine-p-nitroanilide (LN) separately as substrates. With both substrates, amniotic fluid oxytocinase activity correlated inversely with gestational age; the level of the enzyme, which was highest in early pregnancy, decreased exponentially to a minimum near term and during labor. However, whether oxytocinase activity in the amniotic fluid is of any significance for the maintenance and/or termination of pregnancy remains to be established.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 3763071</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Aminopeptidases - metabolism ; Amniotic Fluid - enzymology ; Biological and medical sciences ; Cysteine - analogs & derivatives ; Cysteine - metabolism ; Cystinyl Aminopeptidase - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Humans ; Hydrolysis ; Mother. Fetoplacental unit. Mammary gland. Milk ; Pregnancy ; Pregnancy. Parturition. 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C</creatorcontrib><creatorcontrib>RATNAM, SHAN S</creatorcontrib><title>Oxytocinase Activity in Human Amniotic Fluid and Its Relationship to Gestational Age</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Oxytocinase (EC 3.4.11.3) activity in amniotic fluid samples obtained from 200 normal pregnant women (mean age, 28 years) between 14 and 40 weeks of gestation and during active labor was assayed using S-benzyl-L-cysteine-p-nitroanilide (BCN) and L-leucine-p-nitroanilide (LN) separately as substrates. With both substrates, amniotic fluid oxytocinase activity correlated inversely with gestational age; the level of the enzyme, which was highest in early pregnancy, decreased exponentially to a minimum near term and during labor. However, whether oxytocinase activity in the amniotic fluid is of any significance for the maintenance and/or termination of pregnancy remains to be established.</description><subject>Aminopeptidases - metabolism</subject><subject>Amniotic Fluid - enzymology</subject><subject>Biological and medical sciences</subject><subject>Cysteine - analogs & derivatives</subject><subject>Cysteine - metabolism</subject><subject>Cystinyl Aminopeptidase - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Hydrolysis</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Vertebrates: reproduction</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kN1LwzAUxYsoc07_BCEP4lshN-mS9LEM9wGDgUzwraRJ6qLph03q3H9vdcX7crnn_LgczkU0BcFpTCh9vYymGJM05iJJrqMb798xxsBSOokmlDOKOUyj_e77FBpla-kNylSwXzackK3Ruq9kjbKqtk2wCi1dbzWStUab4NGzcTLYpvYH26LQoJXx4U-QDmVv5ja6KqXz5m7cs-hl-bRfrOPtbrVZZNu4JQLzGAQBjQXjpSpAAOdpWWiMEyBpoZhOEq4BGKUF04ClgjkhiiZ8GAFz4IrOosfz37ZrPvshQ15Zr4xzsjZN73POMUsh4QN4P4J9URmdt52tZHfKxxoG_2H0pVfSlZ2slfX_mACgIMSAJWfs2LhgOv_h-qPp8oORLhzyoV3MyBzHkAoGMFzxr8TpDz5KdJU</recordid><startdate>198611</startdate><enddate>198611</enddate><creator>ROY, ASHIM C</creator><creator>KOTTEGODA, SRI R</creator><creator>VIEGAS, OSBORN A. C</creator><creator>RATNAM, SHAN S</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198611</creationdate><title>Oxytocinase Activity in Human Amniotic Fluid and Its Relationship to Gestational Age</title><author>ROY, ASHIM C ; KOTTEGODA, SRI R ; VIEGAS, OSBORN A. 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Lactation</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROY, ASHIM C</creatorcontrib><creatorcontrib>KOTTEGODA, SRI R</creatorcontrib><creatorcontrib>VIEGAS, OSBORN A. C</creatorcontrib><creatorcontrib>RATNAM, SHAN S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROY, ASHIM C</au><au>KOTTEGODA, SRI R</au><au>VIEGAS, OSBORN A. C</au><au>RATNAM, SHAN S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxytocinase Activity in Human Amniotic Fluid and Its Relationship to Gestational Age</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1986-11</date><risdate>1986</risdate><volume>68</volume><issue>5</issue><spage>614</spage><epage>618</epage><pages>614-618</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Oxytocinase (EC 3.4.11.3) activity in amniotic fluid samples obtained from 200 normal pregnant women (mean age, 28 years) between 14 and 40 weeks of gestation and during active labor was assayed using S-benzyl-L-cysteine-p-nitroanilide (BCN) and L-leucine-p-nitroanilide (LN) separately as substrates. With both substrates, amniotic fluid oxytocinase activity correlated inversely with gestational age; the level of the enzyme, which was highest in early pregnancy, decreased exponentially to a minimum near term and during labor. However, whether oxytocinase activity in the amniotic fluid is of any significance for the maintenance and/or termination of pregnancy remains to be established.</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>3763071</pmid><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1986-11, Vol.68 (5), p.614-618 |
| issn | 0029-7844 1873-233X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77069147 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aminopeptidases - metabolism Amniotic Fluid - enzymology Biological and medical sciences Cysteine - analogs & derivatives Cysteine - metabolism Cystinyl Aminopeptidase - metabolism Female Fundamental and applied biological sciences. Psychology Gestational Age Humans Hydrolysis Mother. Fetoplacental unit. Mammary gland. Milk Pregnancy Pregnancy. Parturition. Lactation Vertebrates: reproduction |
| title | Oxytocinase Activity in Human Amniotic Fluid and Its Relationship to Gestational Age |
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