Enhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic antagonists in mice
The present study examined the effects of pre-test administration of a number of serotonergic receptor antagonists on the retrieval of a previously learned aversive habit in the mouse. All of the receptor antagonists (pirenperone, ketanserin, mianserin, methysergide and metergoline) produced a dose-...
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| Veröffentlicht in: | Psychopharmacologia 1986, Vol.90 (1), p.24-27 |
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| container_title | Psychopharmacologia |
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| creator | ALTMAN, H. J NORMILE, H. J |
| description | The present study examined the effects of pre-test administration of a number of serotonergic receptor antagonists on the retrieval of a previously learned aversive habit in the mouse. All of the receptor antagonists (pirenperone, ketanserin, mianserin, methysergide and metergoline) produced a dose-dependent increase in the latency to complete 5 s of drinking 48 h after training. This suppression of drinking could not be attributed to nonspecific effects of the drugs on behavior (e.g., illness, reduced thirst, or activity), as non-contingently trained mice failed to exhibit similar elevations in their test scores. These results are, therefore, further support for an important role for serotonin in the processes underlying learning and memory. |
| doi_str_mv | 10.1007/BF00172866 |
| format | Article |
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These results are, therefore, further support for an important role for serotonin in the processes underlying learning and memory.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Avoidance Learning - drug effects</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drinking Behavior - drug effects</subject><subject>Exact sciences and technology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Mice</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Other techniques and industries</subject><subject>Pharmacology. Drug treatments</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Serotoninergic system</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFq3DAQhkVpSbdpL70XdCg9BJxIlmVJxyYkbSDQS3o2Y2u0q2JLW0m7YZ-jL1y7u6THzGUY5uNjhp-Qj5xdcsbU1fUdY1zVum1fkRVvRF3VTNWvyYoxISrBpX5L3uX8i83V6OaMnAlmGibVivy5DRsIA04YCo2Olg3SCaeYDssEdJtw7-Mujwc6IqSAlsIeU_Z7pBvofaEujmN88mG9sFXBXCjYyQefS4LiYziK9pA8ln_WjCmWGDCt_UAhFFjHhc7UBzr5Ad-TNw7GjB9O_Zz8vLt9vPlePfz4dn_z9aEa5ldLJQ30VivnmLXSaCWs4AKYEX3jrNCGGdcO6KSqjekNKuhd7RproVZ6QNOKc_Ll6N2m-Hs3H95NPg84jhBwfrlTirWaG_0iyBspGqUW48URHFLMOaHrtslPkA4dZ90SVfc_qhn-dLLu-gntM3rKZt5_Pu0hDzC6NOfk8zOmBZNSvYzVsjGcib_OOara</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>ALTMAN, H. J</creator><creator>NORMILE, H. 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Drug treatments</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Serotoninergic system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALTMAN, H. J</creatorcontrib><creatorcontrib>NORMILE, H. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALTMAN, H. J</au><au>NORMILE, H. 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This suppression of drinking could not be attributed to nonspecific effects of the drugs on behavior (e.g., illness, reduced thirst, or activity), as non-contingently trained mice failed to exhibit similar elevations in their test scores. These results are, therefore, further support for an important role for serotonin in the processes underlying learning and memory.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>3094057</pmid><doi>10.1007/BF00172866</doi><tpages>4</tpages></addata></record> |
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| ispartof | Psychopharmacologia, 1986, Vol.90 (1), p.24-27 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Applied sciences Avoidance Learning - drug effects Biological and medical sciences Dose-Response Relationship, Drug Drinking Behavior - drug effects Exact sciences and technology Male Medical sciences Memory - drug effects Mice Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Other techniques and industries Pharmacology. Drug treatments Serotonin Antagonists - pharmacology Serotoninergic system |
| title | Enhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic antagonists in mice |
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