Assessment of a potential dopaminergic prodrug moiety in several ring systems

The ortho hydroxy/methyl, hydroxy/hydroxymethyl, hydroxy/formyl, and hydroxy/carboxy substitution patterns, some of which confer dopaminergic agonist effects upon 2-aminotetralin ring systems, have been incorporated into beta-phenethylamine, 2-aminoindan, and trans-octahydrobenzo[f]quinoline rings....

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Veröffentlicht in:	Journal of medicinal chemistry 1986-10, Vol.29 (10), p.2016-2020
Hauptverfasser:	Cannon, Joseph G, Furlano, David C, Dushin, Russell G, Chang, Yu An, Baird, Stephen R, Soliman, Laila N, Flynn, Jan R, Long, John Paul, Bhatnagar, Ranbir K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cats General pharmacology Indans - pharmacology Indenes - pharmacology Medical sciences Naphthalenes - pharmacology Pharmacology. Drug treatments Phenethylamines - pharmacology Physicochemical properties. Structure-activity relationships Quinolines - pharmacology Rats Receptors, Dopamine - drug effects Structure-Activity Relationship Tetrahydronaphthalenes - pharmacology
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