Interaction of H-2 genotype and basal serum immunoglobulin a level influences longevity
The congenic pair of mice, C57BL/10 (B10) and C57BL/10.F (B10.F), differ at the H-2 locus and have mean ages at death of 706 and 456 days, respectively. B10.F also has reduced basal serum IgA levels compared with B10, 63 and 256 mg/dl, respectively. Controlled matings between the two strains of mice...
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| Veröffentlicht in: | Mechanisms of ageing and development 1986-09, Vol.36 (1), p.79-93 |
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| creator | Popp, Diana M. Otten, J.A. Popp, R.A. |
| description | The congenic pair of mice, C57BL/10 (B10) and C57BL/10.F (B10.F), differ at the
H-2 locus and have mean ages at death of 706 and 456 days, respectively. B10.F also has reduced basal serum IgA levels compared with B10, 63 and 256 mg/dl, respectively. Controlled matings between the two strains of mice were used to identify genetic factors that govern longevity. F
2 and backcross progeny from reciprocal F
1 hybrids were classified for
H-2 genotype and serum IgA levels and allowed to live out their lifespan. F
2 and backcross progeny homozygous for the
H-2 allele of B10.F had a mean age at death (602 days) significantly reduced from that of progeny homozygous for the
H-2 allele of B10 (689 days). However, the greatest reduction of lifespan occurred among progeny of the (B10.F × B10)F
1 mothers. Survival curves demonstrated a relationship between low serum IgA levels and shortened lifespan and no maternal effect was observed. The basis of the shortened lifespan among progeny of F
1 hybrids in which the maternal parent was B10.F was the increased incidence of offspring with low IgA phenotypes. The apparent association of
H-2 and shortened lifespan also was because the low IgA phenotype was more frequent among progeny that carried the
H-2 allele of the B10.F strain. The B10.F mice spontaneously shed an endogenous ecotropic retrovirus which may be responsible for the maternal effect on immunoglobulin levels and lifespan. |
| doi_str_mv | 10.1016/0047-6374(86)90141-7 |
| format | Article |
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H-2 locus and have mean ages at death of 706 and 456 days, respectively. B10.F also has reduced basal serum IgA levels compared with B10, 63 and 256 mg/dl, respectively. Controlled matings between the two strains of mice were used to identify genetic factors that govern longevity. F
2 and backcross progeny from reciprocal F
1 hybrids were classified for
H-2 genotype and serum IgA levels and allowed to live out their lifespan. F
2 and backcross progeny homozygous for the
H-2 allele of B10.F had a mean age at death (602 days) significantly reduced from that of progeny homozygous for the
H-2 allele of B10 (689 days). However, the greatest reduction of lifespan occurred among progeny of the (B10.F × B10)F
1 mothers. Survival curves demonstrated a relationship between low serum IgA levels and shortened lifespan and no maternal effect was observed. The basis of the shortened lifespan among progeny of F
1 hybrids in which the maternal parent was B10.F was the increased incidence of offspring with low IgA phenotypes. The apparent association of
H-2 and shortened lifespan also was because the low IgA phenotype was more frequent among progeny that carried the
H-2 allele of the B10.F strain. The B10.F mice spontaneously shed an endogenous ecotropic retrovirus which may be responsible for the maternal effect on immunoglobulin levels and lifespan.</description><identifier>ISSN: 0047-6374</identifier><identifier>EISSN: 1872-6216</identifier><identifier>DOI: 10.1016/0047-6374(86)90141-7</identifier><identifier>PMID: 3762236</identifier><identifier>CODEN: MAGDA3</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Classical genetics, quantitative genetics, hybrids ; Fundamental and applied biological sciences. Psychology ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genotype ; H-2 Antigens - genetics ; Immunoglobulin ; Immunoglobulin A - analysis ; Lifespan ; Longevity ; Maternal Effect ; Mice ; Mice, Inbred C57BL - genetics ; Phenotype ; Retrovirus ; Spleen - transplantation ; Vertebrata</subject><ispartof>Mechanisms of ageing and development, 1986-09, Vol.36 (1), p.79-93</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-f156536e94505c3f8c6abd3ccfb22207979fe969bdfddb2011ddb52198b38c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0047-6374(86)90141-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8098150$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3762236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Popp, Diana M.</creatorcontrib><creatorcontrib>Otten, J.A.</creatorcontrib><creatorcontrib>Popp, R.A.</creatorcontrib><title>Interaction of H-2 genotype and basal serum immunoglobulin a level influences longevity</title><title>Mechanisms of ageing and development</title><addtitle>Mech Ageing Dev</addtitle><description>The congenic pair of mice, C57BL/10 (B10) and C57BL/10.F (B10.F), differ at the
H-2 locus and have mean ages at death of 706 and 456 days, respectively. B10.F also has reduced basal serum IgA levels compared with B10, 63 and 256 mg/dl, respectively. Controlled matings between the two strains of mice were used to identify genetic factors that govern longevity. F
2 and backcross progeny from reciprocal F
1 hybrids were classified for
H-2 genotype and serum IgA levels and allowed to live out their lifespan. F
2 and backcross progeny homozygous for the
H-2 allele of B10.F had a mean age at death (602 days) significantly reduced from that of progeny homozygous for the
H-2 allele of B10 (689 days). However, the greatest reduction of lifespan occurred among progeny of the (B10.F × B10)F
1 mothers. Survival curves demonstrated a relationship between low serum IgA levels and shortened lifespan and no maternal effect was observed. The basis of the shortened lifespan among progeny of F
1 hybrids in which the maternal parent was B10.F was the increased incidence of offspring with low IgA phenotypes. The apparent association of
H-2 and shortened lifespan also was because the low IgA phenotype was more frequent among progeny that carried the
H-2 allele of the B10.F strain. The B10.F mice spontaneously shed an endogenous ecotropic retrovirus which may be responsible for the maternal effect on immunoglobulin levels and lifespan.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genotype</subject><subject>H-2 Antigens - genetics</subject><subject>Immunoglobulin</subject><subject>Immunoglobulin A - analysis</subject><subject>Lifespan</subject><subject>Longevity</subject><subject>Maternal Effect</subject><subject>Mice</subject><subject>Mice, Inbred C57BL - genetics</subject><subject>Phenotype</subject><subject>Retrovirus</subject><subject>Spleen - transplantation</subject><subject>Vertebrata</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoOj7-gUIWIrqo5tEm7UYQ8QWCG8FlSNObIZImY9IOzL-34wyzdHUX5zuHy4fQOSW3lFBxR0gpC8FleV2Lm4bQkhZyD81oLVkhGBX7aLZDjtBxzt-ETBQTh-iQS8EYFzP09RYGSNoMLgYcLX4tGJ5DiMNqAViHDrc6a48zpLHHru_HEOc-tqN3AWvsYQkeu2D9CMFAxj6GOSzdsDpFB1b7DGfbe4I-n58-H1-L94-Xt8eH98JwXg2FpZWouICmrEhluK2N0G3HjbEtY4zIRjYWGtG0ne26lhFKp1Mx2tQtrw3lJ-hqM7tI8WeEPKjeZQPe6wBxzEpKIphkfALLDWhSzDmBVYvkep1WihK11qnWrtTalaqF-tOp5FS72O6PbQ_drrT1N-WX21xno71NOhiXd1hNmppWZMLuNxhMKpYOksrGrY11LoEZVBfd_3_8Am67kUA</recordid><startdate>19860901</startdate><enddate>19860901</enddate><creator>Popp, Diana M.</creator><creator>Otten, J.A.</creator><creator>Popp, R.A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860901</creationdate><title>Interaction of H-2 genotype and basal serum immunoglobulin a level influences longevity</title><author>Popp, Diana M. ; Otten, J.A. ; Popp, R.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-f156536e94505c3f8c6abd3ccfb22207979fe969bdfddb2011ddb52198b38c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genotype</topic><topic>H-2 Antigens - genetics</topic><topic>Immunoglobulin</topic><topic>Immunoglobulin A - analysis</topic><topic>Lifespan</topic><topic>Longevity</topic><topic>Maternal Effect</topic><topic>Mice</topic><topic>Mice, Inbred C57BL - genetics</topic><topic>Phenotype</topic><topic>Retrovirus</topic><topic>Spleen - transplantation</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Popp, Diana M.</creatorcontrib><creatorcontrib>Otten, J.A.</creatorcontrib><creatorcontrib>Popp, R.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Popp, Diana M.</au><au>Otten, J.A.</au><au>Popp, R.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of H-2 genotype and basal serum immunoglobulin a level influences longevity</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>1986-09-01</date><risdate>1986</risdate><volume>36</volume><issue>1</issue><spage>79</spage><epage>93</epage><pages>79-93</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><coden>MAGDA3</coden><abstract>The congenic pair of mice, C57BL/10 (B10) and C57BL/10.F (B10.F), differ at the
H-2 locus and have mean ages at death of 706 and 456 days, respectively. B10.F also has reduced basal serum IgA levels compared with B10, 63 and 256 mg/dl, respectively. Controlled matings between the two strains of mice were used to identify genetic factors that govern longevity. F
2 and backcross progeny from reciprocal F
1 hybrids were classified for
H-2 genotype and serum IgA levels and allowed to live out their lifespan. F
2 and backcross progeny homozygous for the
H-2 allele of B10.F had a mean age at death (602 days) significantly reduced from that of progeny homozygous for the
H-2 allele of B10 (689 days). However, the greatest reduction of lifespan occurred among progeny of the (B10.F × B10)F
1 mothers. Survival curves demonstrated a relationship between low serum IgA levels and shortened lifespan and no maternal effect was observed. The basis of the shortened lifespan among progeny of F
1 hybrids in which the maternal parent was B10.F was the increased incidence of offspring with low IgA phenotypes. The apparent association of
H-2 and shortened lifespan also was because the low IgA phenotype was more frequent among progeny that carried the
H-2 allele of the B10.F strain. The B10.F mice spontaneously shed an endogenous ecotropic retrovirus which may be responsible for the maternal effect on immunoglobulin levels and lifespan.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3762236</pmid><doi>10.1016/0047-6374(86)90141-7</doi><tpages>15</tpages></addata></record> |
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| ispartof | Mechanisms of ageing and development, 1986-09, Vol.36 (1), p.79-93 |
| issn | 0047-6374 1872-6216 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Genetics Genetics of eukaryotes. Biological and molecular evolution Genotype H-2 Antigens - genetics Immunoglobulin Immunoglobulin A - analysis Lifespan Longevity Maternal Effect Mice Mice, Inbred C57BL - genetics Phenotype Retrovirus Spleen - transplantation Vertebrata |
| title | Interaction of H-2 genotype and basal serum immunoglobulin a level influences longevity |
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