Studies on Drug—Milk Freeze-Dried Formulations I: Bioavailability of Sulfamethizole and Dicumarol Formulations

In this study, solid dispersion formulations of dicumarol (3,3′-methylenebis[4-hydroxycoumarin]) and sulfamethizole (N'-(5-methyl-1,3,4-thiadiazol-2-yl)sulfanilamide) in defatted milk were prepared by freeze-drying. X-ray crystallographic data showed that both drugs were dispersed in the formul...

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