Stimulation of epithelial tissue migration by certain porous topographies is independent of fluid flux
A surface with columnar pores 0.1 or 0.4 μm in diameter is shown to have a novel effect on the migration of corneal epithelial tissue sheets; migration is stimulated in a nondirectional manner with respect to migration over a planar, nonporous surface (Dalton, Evans, McFarland, and Steele, J Biomed...
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| Veröffentlicht in: | Journal of biomedical materials research 2001-07, Vol.56 (1), p.83-92 |
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| creator | Dalton, B. Ann McFarland, Gail A. Steele, John G. |
| description | A surface with columnar pores 0.1 or 0.4 μm in diameter is shown to have a novel effect on the migration of corneal epithelial tissue sheets; migration is stimulated in a nondirectional manner with respect to migration over a planar, nonporous surface (Dalton, Evans, McFarland, and Steele, J Biomed Mater Res 1999;45:384–394; Steele, Johnson, McLean, Beumer, and Griesser, J Biomed Mater Res 2000;50:475–482). By blind‐ending the pores, we show that this increase in tissue migration is not dependent on fluid flux through the pores and so appears to occur as a result of surface topography. From transmission electron micrographs, the migrating tissue appears to form either close contacts or focal adhesions at the edge of some pore channels; we speculate that this may provide a fulcrum for the enhanced migration. Scanning electron micrographs suggest that within tissue that migrates over the surfaces that contain blind‐ended pores, the cells are more extensively spread than those in tissue migrating on a planar surface. The migration of disaggregated epithelial cells is enhanced on surfaces that contain 0.1‐ or 0.4‐μm‐diameter pores (compared with a planar surface), and this is similarly independent of fluid flux. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res 56: 83–92, 2001 |
| doi_str_mv | 10.1002/1097-4636(200107)56:1<83::AID-JBM1071>3.0.CO;2-H |
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Ann ; McFarland, Gail A. ; Steele, John G.</creator><creatorcontrib>Dalton, B. Ann ; McFarland, Gail A. ; Steele, John G.</creatorcontrib><description>A surface with columnar pores 0.1 or 0.4 μm in diameter is shown to have a novel effect on the migration of corneal epithelial tissue sheets; migration is stimulated in a nondirectional manner with respect to migration over a planar, nonporous surface (Dalton, Evans, McFarland, and Steele, J Biomed Mater Res 1999;45:384–394; Steele, Johnson, McLean, Beumer, and Griesser, J Biomed Mater Res 2000;50:475–482). By blind‐ending the pores, we show that this increase in tissue migration is not dependent on fluid flux through the pores and so appears to occur as a result of surface topography. From transmission electron micrographs, the migrating tissue appears to form either close contacts or focal adhesions at the edge of some pore channels; we speculate that this may provide a fulcrum for the enhanced migration. Scanning electron micrographs suggest that within tissue that migrates over the surfaces that contain blind‐ended pores, the cells are more extensively spread than those in tissue migrating on a planar surface. The migration of disaggregated epithelial cells is enhanced on surfaces that contain 0.1‐ or 0.4‐μm‐diameter pores (compared with a planar surface), and this is similarly independent of fluid flux. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res 56: 83–92, 2001</description><identifier>ISSN: 0021-9304</identifier><identifier>EISSN: 1097-4636</identifier><identifier>DOI: 10.1002/1097-4636(200107)56:1<83::AID-JBM1071>3.0.CO;2-H</identifier><identifier>PMID: 11309794</identifier><identifier>CODEN: JBMRBG</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biocompatible Materials ; Biological and medical sciences ; Cattle ; Cell Adhesion - physiology ; Cell Movement - physiology ; Cells, Cultured ; Culture Techniques - methods ; enhanced migration ; epithelial tissue ; Epithelium, Corneal - cytology ; fluid flux ; Kinetics ; Medical sciences ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Polycarboxylate Cement ; pores ; Porosity ; Rheology ; Surface Properties ; surface topography ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. 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Ann</creatorcontrib><creatorcontrib>McFarland, Gail A.</creatorcontrib><creatorcontrib>Steele, John G.</creatorcontrib><title>Stimulation of epithelial tissue migration by certain porous topographies is independent of fluid flux</title><title>Journal of biomedical materials research</title><addtitle>J. Biomed. Mater. Res</addtitle><description>A surface with columnar pores 0.1 or 0.4 μm in diameter is shown to have a novel effect on the migration of corneal epithelial tissue sheets; migration is stimulated in a nondirectional manner with respect to migration over a planar, nonporous surface (Dalton, Evans, McFarland, and Steele, J Biomed Mater Res 1999;45:384–394; Steele, Johnson, McLean, Beumer, and Griesser, J Biomed Mater Res 2000;50:475–482). By blind‐ending the pores, we show that this increase in tissue migration is not dependent on fluid flux through the pores and so appears to occur as a result of surface topography. From transmission electron micrographs, the migrating tissue appears to form either close contacts or focal adhesions at the edge of some pore channels; we speculate that this may provide a fulcrum for the enhanced migration. Scanning electron micrographs suggest that within tissue that migrates over the surfaces that contain blind‐ended pores, the cells are more extensively spread than those in tissue migrating on a planar surface. The migration of disaggregated epithelial cells is enhanced on surfaces that contain 0.1‐ or 0.4‐μm‐diameter pores (compared with a planar surface), and this is similarly independent of fluid flux. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res 56: 83–92, 2001</description><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cell Adhesion - physiology</subject><subject>Cell Movement - physiology</subject><subject>Cells, Cultured</subject><subject>Culture Techniques - methods</subject><subject>enhanced migration</subject><subject>epithelial tissue</subject><subject>Epithelium, Corneal - cytology</subject><subject>fluid flux</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Electron, Scanning</subject><subject>Polycarboxylate Cement</subject><subject>pores</subject><subject>Porosity</subject><subject>Rheology</subject><subject>Surface Properties</subject><subject>surface topography</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><issn>0021-9304</issn><issn>1097-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF2L1DAUhoMo7uzqX5CCIO5Fx6Rpm3QUYR11Z3XdERyZy0PanrjRfpm0uPPvTWkdb7wQQgLnPHnO4SVEMrpklEYvGM1EGKc8fR5Ryqg4T9IVeyX5anVx9Tb88OaTr7HXfEmX6-3LKNzcI4vjl_tk4RUszDiNT8ipc98ppVnG2UNywhj3WBYviP7Sm3qoVG_aJmh1gJ3pb7Eyqgp649yAQW2-2amdH4ICba9ME3StbQcX9G3X-m53a9AFxp-mxA791fSjTFeDKcf77hF5oFXl8PH8npGv79_t1pvwent5tb64Dos44ixUGVMppmWMGRa5pCpKNC9knEsp4tiXkKLGQuskjmipMUdOIxSSCyoTnkl-Rp5N3s62Pwd0PdTGFVhVqkG_MAhBU-ZHefDzBBa2dc6ihs6aWtkDMApj9jAGCWOQMGUPSQoMJAfw2cOcPXCgsN5CBBuvfDLPHvIay7_COWwPPJ0B5QpVaauawrgjl0nJxEjtJuqXqfDw_2v9e6s_Ja8NJ61xPd4dtcr-gFRwkcD-5hKS3c3HLN3vgfPfO9G6YQ</recordid><startdate>200107</startdate><enddate>200107</enddate><creator>Dalton, B. Ann</creator><creator>McFarland, Gail A.</creator><creator>Steele, John G.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200107</creationdate><title>Stimulation of epithelial tissue migration by certain porous topographies is independent of fluid flux</title><author>Dalton, B. Ann ; McFarland, Gail A. ; Steele, John G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4231-a91a6e6d4e9ecb80a25f3c84b88744ecbe0efecff5420dfebe302e78370853983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cell Adhesion - physiology</topic><topic>Cell Movement - physiology</topic><topic>Cells, Cultured</topic><topic>Culture Techniques - methods</topic><topic>enhanced migration</topic><topic>epithelial tissue</topic><topic>Epithelium, Corneal - cytology</topic><topic>fluid flux</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Electron, Scanning</topic><topic>Polycarboxylate Cement</topic><topic>pores</topic><topic>Porosity</topic><topic>Rheology</topic><topic>Surface Properties</topic><topic>surface topography</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><toplevel>online_resources</toplevel><creatorcontrib>Dalton, B. Ann</creatorcontrib><creatorcontrib>McFarland, Gail A.</creatorcontrib><creatorcontrib>Steele, John G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dalton, B. Ann</au><au>McFarland, Gail A.</au><au>Steele, John G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulation of epithelial tissue migration by certain porous topographies is independent of fluid flux</atitle><jtitle>Journal of biomedical materials research</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2001-07</date><risdate>2001</risdate><volume>56</volume><issue>1</issue><spage>83</spage><epage>92</epage><pages>83-92</pages><issn>0021-9304</issn><eissn>1097-4636</eissn><coden>JBMRBG</coden><abstract>A surface with columnar pores 0.1 or 0.4 μm in diameter is shown to have a novel effect on the migration of corneal epithelial tissue sheets; migration is stimulated in a nondirectional manner with respect to migration over a planar, nonporous surface (Dalton, Evans, McFarland, and Steele, J Biomed Mater Res 1999;45:384–394; Steele, Johnson, McLean, Beumer, and Griesser, J Biomed Mater Res 2000;50:475–482). By blind‐ending the pores, we show that this increase in tissue migration is not dependent on fluid flux through the pores and so appears to occur as a result of surface topography. From transmission electron micrographs, the migrating tissue appears to form either close contacts or focal adhesions at the edge of some pore channels; we speculate that this may provide a fulcrum for the enhanced migration. Scanning electron micrographs suggest that within tissue that migrates over the surfaces that contain blind‐ended pores, the cells are more extensively spread than those in tissue migrating on a planar surface. The migration of disaggregated epithelial cells is enhanced on surfaces that contain 0.1‐ or 0.4‐μm‐diameter pores (compared with a planar surface), and this is similarly independent of fluid flux. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res 56: 83–92, 2001</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11309794</pmid><doi>10.1002/1097-4636(200107)56:1<83::AID-JBM1071>3.0.CO;2-H</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biocompatible Materials Biological and medical sciences Cattle Cell Adhesion - physiology Cell Movement - physiology Cells, Cultured Culture Techniques - methods enhanced migration epithelial tissue Epithelium, Corneal - cytology fluid flux Kinetics Medical sciences Microscopy, Electron Microscopy, Electron, Scanning Polycarboxylate Cement pores Porosity Rheology Surface Properties surface topography Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments |
| title | Stimulation of epithelial tissue migration by certain porous topographies is independent of fluid flux |
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