Platelet Adhesion Enhances the Glycoprotein VI-Dependent Procoagulant Response: Involvement of p38 MAP Kinase and Calpain

ABSTRACT—In the final stages of activation, platelets express coagulation-promoting activity by 2 simultaneous processesexposure of aminophospholipids, eg, phosphatidylserine (PS), at the platelet surface, and formation of membrane blebs, which may be shed as microvesicles. Contact with collagen tri...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2001-04, Vol.21 (4), p.618-627
Hauptverfasser:	Siljander, Pia, Farndale, Richard W, Feijge, Marion A.H, Comfurius, Paul, Kos, Snjezana, Bevers, Edouard M, Heemskerk, Johan W.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood coagulation. Blood cells Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - physiology Blotting, Western Calcium - metabolism Calcium - physiology Calpain - metabolism Calpain - pharmacology Carrier Proteins Crotalid Venoms - metabolism Crotalid Venoms - pharmacology Enzyme Activation Flow Cytometry Fundamental and applied biological sciences. Psychology Humans Lectins, C-Type Microscopy, Electron, Scanning Microscopy, Fluorescence Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - pharmacology Molecular and cellular biology p38 Mitogen-Activated Protein Kinases Phosphatidylserines - metabolism Phosphatidylserines - pharmacology Phosphorylation Platelet Platelet Activation - drug effects Platelet Activation - physiology Platelet Adhesiveness - drug effects Platelet Adhesiveness - physiology Platelet Membrane Glycoproteins - metabolism Platelet Membrane Glycoproteins - pharmacology Proteins - metabolism Proteins - pharmacology Signal Transduction - drug effects Signal Transduction - physiology
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