Polymorphonuclear leukocyte dysfunction associated with feline leukaemia virus infection
1 Department of Veterinary Pathobiology and The 2 Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, U.S.A. The chemiluminescent characteristics of enriched (>95%) peripheral blood polymorphonuclear leukocyte populations (PMN) from normal and feline leukaemia virus (FeL...
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| Veröffentlicht in: | Journal of general virology 1986-10, Vol.67 (10), p.2113-2118 |
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| container_issue | 10 |
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| container_title | Journal of general virology |
| container_volume | 67 |
| creator | Lewis, M.G Duska, G.O Stiff, M.I Lafrado, L.J Olsen, R.G |
| description | 1 Department of Veterinary Pathobiology
and The 2 Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, U.S.A.
The chemiluminescent characteristics of enriched (>95%) peripheral blood polymorphonuclear leukocyte populations (PMN) from normal and feline leukaemia virus (FeLV)-infected cats were investigated. FeLV-infected cats demonstrated a significantly lower ( P < 0.001) PMN chemiluminescent response when compared to the response of normal age-matched controls. Normal PMN treated with FeLV-infected cat serum exhibited a depressed response in comparison to control cells. A titration of serum from infected cats supplemented with normal serum revealed a titratable suppression of chemiluminescence with increasing concentration of serum from the infected cats. However, PMN from FeLV-infected cats treated with normal serum displayed a slight increase in chemiluminescence over the same cells in autologous serum. The addition of inactivated FeLV to normal PMN caused a titratable decrease in chemiluminescence.
Keywords: feline leukaemia virus, neutrophil, dysfunction
Received 13 March 1986;
accepted 7 July 1986. |
| doi_str_mv | 10.1099/0022-1317-67-10-2113 |
| format | Article |
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and The 2 Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, U.S.A.
The chemiluminescent characteristics of enriched (>95%) peripheral blood polymorphonuclear leukocyte populations (PMN) from normal and feline leukaemia virus (FeLV)-infected cats were investigated. FeLV-infected cats demonstrated a significantly lower ( P < 0.001) PMN chemiluminescent response when compared to the response of normal age-matched controls. Normal PMN treated with FeLV-infected cat serum exhibited a depressed response in comparison to control cells. A titration of serum from infected cats supplemented with normal serum revealed a titratable suppression of chemiluminescence with increasing concentration of serum from the infected cats. However, PMN from FeLV-infected cats treated with normal serum displayed a slight increase in chemiluminescence over the same cells in autologous serum. The addition of inactivated FeLV to normal PMN caused a titratable decrease in chemiluminescence.
Keywords: feline leukaemia virus, neutrophil, dysfunction
Received 13 March 1986;
accepted 7 July 1986.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-67-10-2113</identifier><identifier>PMID: 3020157</identifier><identifier>CODEN: JGVIAY</identifier><language>eng</language><publisher>Reading: Soc General Microbiol</publisher><subject>Animal viral diseases ; Animals ; Antigens, Viral - analysis ; Biological and medical sciences ; Cats ; feline leukemia virus ; feline oncovirus ; infection ; Infectious diseases ; leukemia ; Leukemia Virus, Feline - immunology ; Leukemia Virus, Feline - radiation effects ; Leukemia, Experimental - immunology ; leukocytes ; Luminescent Measurements ; Medical sciences ; Neutrophils - immunology ; Neutrophils - metabolism ; phagocytosis ; Specific Pathogen-Free Organisms ; Ultraviolet Rays ; Viral diseases ; Viremia</subject><ispartof>Journal of general virology, 1986-10, Vol.67 (10), p.2113-2118</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-d211b9b27210dd1c35df3289f0524474cd4759c840c7255ab3dccfcf45a4ac363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3733,3734,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8258105$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3020157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lewis, M.G</creatorcontrib><creatorcontrib>Duska, G.O</creatorcontrib><creatorcontrib>Stiff, M.I</creatorcontrib><creatorcontrib>Lafrado, L.J</creatorcontrib><creatorcontrib>Olsen, R.G</creatorcontrib><title>Polymorphonuclear leukocyte dysfunction associated with feline leukaemia virus infection</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>1 Department of Veterinary Pathobiology
and The 2 Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, U.S.A.
The chemiluminescent characteristics of enriched (>95%) peripheral blood polymorphonuclear leukocyte populations (PMN) from normal and feline leukaemia virus (FeLV)-infected cats were investigated. FeLV-infected cats demonstrated a significantly lower ( P < 0.001) PMN chemiluminescent response when compared to the response of normal age-matched controls. Normal PMN treated with FeLV-infected cat serum exhibited a depressed response in comparison to control cells. A titration of serum from infected cats supplemented with normal serum revealed a titratable suppression of chemiluminescence with increasing concentration of serum from the infected cats. However, PMN from FeLV-infected cats treated with normal serum displayed a slight increase in chemiluminescence over the same cells in autologous serum. The addition of inactivated FeLV to normal PMN caused a titratable decrease in chemiluminescence.
Keywords: feline leukaemia virus, neutrophil, dysfunction
Received 13 March 1986;
accepted 7 July 1986.</description><subject>Animal viral diseases</subject><subject>Animals</subject><subject>Antigens, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>feline leukemia virus</subject><subject>feline oncovirus</subject><subject>infection</subject><subject>Infectious diseases</subject><subject>leukemia</subject><subject>Leukemia Virus, Feline - immunology</subject><subject>Leukemia Virus, Feline - radiation effects</subject><subject>Leukemia, Experimental - immunology</subject><subject>leukocytes</subject><subject>Luminescent Measurements</subject><subject>Medical sciences</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>phagocytosis</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Ultraviolet Rays</subject><subject>Viral diseases</subject><subject>Viremia</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2LFDEQhoO4rOPqP1DsgwgeWitfnenjsvgFC7ugC95CupLMRLs7Y9LtMv9-0zvDgCdPgdRTbxUPRcgrCh8otO1HAMZqyqmqG1VTqBml_AlZUdHImhXgKVmdkGfkec6_AKgQUp2Tcw4MqFQr8vM29vshpt02jjP2zqSqd_PviPvJVXaf_TziFOJYmZwjBjM5W92HaVt514fRPcLGDcFUf0OacxVG7x4bXpAzb_rsXh7fC3L3-dOPq6_19c2Xb1eX1zWKpplqW7bu2o4pRsFailxaz9m69SCZEEqgFUq2uBaAiklpOm4RPXohjTDIG35B3h1ydyn-mV2e9BAyur43o4tz1kpBA8XAf8HijUohl0RxADHFnJPzepfCYNJeU9CLeb1o1YtW3ajlczFf2l4f8-ducPbUdFRd6m-PdZPR9D6ZEUM-YWsm1xRkwd4fsG3YbO9DcnrjxiGUXboQdZH8z8g3B9abqM0mlbi772Uah-UIWqH4AzSJo9k</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>Lewis, M.G</creator><creator>Duska, G.O</creator><creator>Stiff, M.I</creator><creator>Lafrado, L.J</creator><creator>Olsen, R.G</creator><general>Soc General Microbiol</general><general>Society for General Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19861001</creationdate><title>Polymorphonuclear leukocyte dysfunction associated with feline leukaemia virus infection</title><author>Lewis, M.G ; Duska, G.O ; Stiff, M.I ; Lafrado, L.J ; Olsen, R.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-d211b9b27210dd1c35df3289f0524474cd4759c840c7255ab3dccfcf45a4ac363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animal viral diseases</topic><topic>Animals</topic><topic>Antigens, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>feline leukemia virus</topic><topic>feline oncovirus</topic><topic>infection</topic><topic>Infectious diseases</topic><topic>leukemia</topic><topic>Leukemia Virus, Feline - immunology</topic><topic>Leukemia Virus, Feline - radiation effects</topic><topic>Leukemia, Experimental - immunology</topic><topic>leukocytes</topic><topic>Luminescent Measurements</topic><topic>Medical sciences</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - metabolism</topic><topic>phagocytosis</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Ultraviolet Rays</topic><topic>Viral diseases</topic><topic>Viremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lewis, M.G</creatorcontrib><creatorcontrib>Duska, G.O</creatorcontrib><creatorcontrib>Stiff, M.I</creatorcontrib><creatorcontrib>Lafrado, L.J</creatorcontrib><creatorcontrib>Olsen, R.G</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lewis, M.G</au><au>Duska, G.O</au><au>Stiff, M.I</au><au>Lafrado, L.J</au><au>Olsen, R.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphonuclear leukocyte dysfunction associated with feline leukaemia virus infection</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>67</volume><issue>10</issue><spage>2113</spage><epage>2118</epage><pages>2113-2118</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><coden>JGVIAY</coden><abstract>1 Department of Veterinary Pathobiology
and The 2 Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, U.S.A.
The chemiluminescent characteristics of enriched (>95%) peripheral blood polymorphonuclear leukocyte populations (PMN) from normal and feline leukaemia virus (FeLV)-infected cats were investigated. FeLV-infected cats demonstrated a significantly lower ( P < 0.001) PMN chemiluminescent response when compared to the response of normal age-matched controls. Normal PMN treated with FeLV-infected cat serum exhibited a depressed response in comparison to control cells. A titration of serum from infected cats supplemented with normal serum revealed a titratable suppression of chemiluminescence with increasing concentration of serum from the infected cats. However, PMN from FeLV-infected cats treated with normal serum displayed a slight increase in chemiluminescence over the same cells in autologous serum. The addition of inactivated FeLV to normal PMN caused a titratable decrease in chemiluminescence.
Keywords: feline leukaemia virus, neutrophil, dysfunction
Received 13 March 1986;
accepted 7 July 1986.</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>3020157</pmid><doi>10.1099/0022-1317-67-10-2113</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animal viral diseases Animals Antigens, Viral - analysis Biological and medical sciences Cats feline leukemia virus feline oncovirus infection Infectious diseases leukemia Leukemia Virus, Feline - immunology Leukemia Virus, Feline - radiation effects Leukemia, Experimental - immunology leukocytes Luminescent Measurements Medical sciences Neutrophils - immunology Neutrophils - metabolism phagocytosis Specific Pathogen-Free Organisms Ultraviolet Rays Viral diseases Viremia |
| title | Polymorphonuclear leukocyte dysfunction associated with feline leukaemia virus infection |
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