Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics
Whole genome scan analyses have revealed that chromosomal region 3p21-24, which contains a gene cluster of CC chemokine receptors such as CCR3, is possibly linked to asthma. Because CCR3 ligands play a pivotal role in the selective recruitment and activation of inflammatory cells in the asthmatic ai...
Gespeichert in:
| Veröffentlicht in: | The European respiratory journal 2001-01, Vol.17 (1), p.59-63 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 63 |
|---|---|
| container_issue | 1 |
| container_start_page | 59 |
| container_title | The European respiratory journal |
| container_volume | 17 |
| creator | Fukunaga, K Asano, K Mao, X-Q Gao, P-S Roberts, M.H Oguma, T Shiomi, T Kanazawa, M Adra, C.N Shirakawa, T Hopkin, J.M Yamaguchi, K |
| description | Whole genome scan analyses have revealed that chromosomal region 3p21-24, which contains a gene cluster of CC chemokine receptors such as CCR3, is possibly linked to asthma. Because CCR3 ligands play a pivotal role in the selective recruitment and activation of inflammatory cells in the asthmatic airway, the authors examined whether there is any association between asthma and the CCR3 gene polymorphisms. Three polymorphisms were identified using the single stranded conformational polymorphism method in Japanese (Asian) and British (Caucasian) subjects; one silent mutation T51C and two missense mutations G824A and T971C. These polymorphisms were examined in 391 Japanese subjects (210 asthmatics and 181 nonasthmatic controls) and 234 British subjects (142 asthmatics and 92 nonasthmatic controls). Asthma diagnosis was based on episodic symptoms, documented wheeze, and the presence of reversible airflow limitation. CCR3 T51C demonstrated a significant association with the diagnosis of asthma in the British population (odds ratio 2.35, p |
| doi_str_mv | 10.1183/09031936.01.17100590 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77060219</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77060219</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-655a86c7928f118c206c887699194840a06884499afc67265a45dc973a2fb6f43</originalsourceid><addsrcrecordid>eNpFkE1P3DAQhi1UBMvCP6gqS624ZZmJHTs-lgi2RUgcCmfLeJ3GNF_1ZFXtv29Wu7SnuTzvMzMvYx8RVoiluAEDAo1QK8AVagQoDJywBQpjMgEgPrDFHsn2zDm7IHoDQCUFnrFzRAFaF2rBfqxDH6bo-Ti0u25IYxOpIz7UvKq4b0I3_Ip94Cn4ME5D4oLHnj-40fWBAnf9ht-mOEVquKOp6dysokt2WruWwtVxLtnL_d1z9S17fFp_r74-Zl5qOWWqKFypvDZ5Wc8f-RyUL0utjEEjSwkOVFlKaYyrvdK5KpwsNt5o4fL6VdVSLNn1wTum4fc20GS7SD607XzcsCWrNSjI5_-XTB5AnwaiFGo7pti5tLMIdl-mfS_TAtr3MufYp6N_-9qFzf_Qsb0Z-HwEHHnX1sn1PtI_zoCSar_9y4Fq4s_mT0zBUufadpaiDekNtUVbGPEXCFqGpg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77060219</pqid></control><display><type>article</type><title>Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Fukunaga, K ; Asano, K ; Mao, X-Q ; Gao, P-S ; Roberts, M.H ; Oguma, T ; Shiomi, T ; Kanazawa, M ; Adra, C.N ; Shirakawa, T ; Hopkin, J.M ; Yamaguchi, K</creator><creatorcontrib>Fukunaga, K ; Asano, K ; Mao, X-Q ; Gao, P-S ; Roberts, M.H ; Oguma, T ; Shiomi, T ; Kanazawa, M ; Adra, C.N ; Shirakawa, T ; Hopkin, J.M ; Yamaguchi, K</creatorcontrib><description>Whole genome scan analyses have revealed that chromosomal region 3p21-24, which contains a gene cluster of CC chemokine receptors such as CCR3, is possibly linked to asthma. Because CCR3 ligands play a pivotal role in the selective recruitment and activation of inflammatory cells in the asthmatic airway, the authors examined whether there is any association between asthma and the CCR3 gene polymorphisms. Three polymorphisms were identified using the single stranded conformational polymorphism method in Japanese (Asian) and British (Caucasian) subjects; one silent mutation T51C and two missense mutations G824A and T971C. These polymorphisms were examined in 391 Japanese subjects (210 asthmatics and 181 nonasthmatic controls) and 234 British subjects (142 asthmatics and 92 nonasthmatic controls). Asthma diagnosis was based on episodic symptoms, documented wheeze, and the presence of reversible airflow limitation. CCR3 T51C demonstrated a significant association with the diagnosis of asthma in the British population (odds ratio 2.35, p<0.01), but not in the Japanese population. Multiple logistic regression analysis also showed that CCR3 T51C was associated with asthma (odds ratio 2.83, p < 0.02), independent of atopic phenotypes such as high levels of total or house dust mite-specific immunoglobulin-E in serum. In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.01.17100590</identifier><identifier>PMID: 11307756</identifier><language>eng</language><publisher>Leeds: Eur Respiratory Soc</publisher><subject>Alleles ; Asian Continental Ancestry Group - genetics ; Asthma - genetics ; Asthma - immunology ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; European Continental Ancestry Group - genetics ; Genetics, Population ; Humans ; Hypersensitivity, Immediate - complications ; Hypersensitivity, Immediate - diagnosis ; Japan ; Medical sciences ; Mutation ; Mutation, Missense ; Pneumology ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single-Stranded Conformational ; Receptors, CCR3 ; Receptors, Chemokine - genetics ; United Kingdom</subject><ispartof>The European respiratory journal, 2001-01, Vol.17 (1), p.59-63</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-655a86c7928f118c206c887699194840a06884499afc67265a45dc973a2fb6f43</citedby><cites>FETCH-LOGICAL-c474t-655a86c7928f118c206c887699194840a06884499afc67265a45dc973a2fb6f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=906469$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11307756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukunaga, K</creatorcontrib><creatorcontrib>Asano, K</creatorcontrib><creatorcontrib>Mao, X-Q</creatorcontrib><creatorcontrib>Gao, P-S</creatorcontrib><creatorcontrib>Roberts, M.H</creatorcontrib><creatorcontrib>Oguma, T</creatorcontrib><creatorcontrib>Shiomi, T</creatorcontrib><creatorcontrib>Kanazawa, M</creatorcontrib><creatorcontrib>Adra, C.N</creatorcontrib><creatorcontrib>Shirakawa, T</creatorcontrib><creatorcontrib>Hopkin, J.M</creatorcontrib><creatorcontrib>Yamaguchi, K</creatorcontrib><title>Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Whole genome scan analyses have revealed that chromosomal region 3p21-24, which contains a gene cluster of CC chemokine receptors such as CCR3, is possibly linked to asthma. Because CCR3 ligands play a pivotal role in the selective recruitment and activation of inflammatory cells in the asthmatic airway, the authors examined whether there is any association between asthma and the CCR3 gene polymorphisms. Three polymorphisms were identified using the single stranded conformational polymorphism method in Japanese (Asian) and British (Caucasian) subjects; one silent mutation T51C and two missense mutations G824A and T971C. These polymorphisms were examined in 391 Japanese subjects (210 asthmatics and 181 nonasthmatic controls) and 234 British subjects (142 asthmatics and 92 nonasthmatic controls). Asthma diagnosis was based on episodic symptoms, documented wheeze, and the presence of reversible airflow limitation. CCR3 T51C demonstrated a significant association with the diagnosis of asthma in the British population (odds ratio 2.35, p<0.01), but not in the Japanese population. Multiple logistic regression analysis also showed that CCR3 T51C was associated with asthma (odds ratio 2.83, p < 0.02), independent of atopic phenotypes such as high levels of total or house dust mite-specific immunoglobulin-E in serum. In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found.</description><subject>Alleles</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Asthma - genetics</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Genetics, Population</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - complications</subject><subject>Hypersensitivity, Immediate - diagnosis</subject><subject>Japan</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Mutation, Missense</subject><subject>Pneumology</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single-Stranded Conformational</subject><subject>Receptors, CCR3</subject><subject>Receptors, Chemokine - genetics</subject><subject>United Kingdom</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1P3DAQhi1UBMvCP6gqS624ZZmJHTs-lgi2RUgcCmfLeJ3GNF_1ZFXtv29Wu7SnuTzvMzMvYx8RVoiluAEDAo1QK8AVagQoDJywBQpjMgEgPrDFHsn2zDm7IHoDQCUFnrFzRAFaF2rBfqxDH6bo-Ti0u25IYxOpIz7UvKq4b0I3_Ip94Cn4ME5D4oLHnj-40fWBAnf9ht-mOEVquKOp6dysokt2WruWwtVxLtnL_d1z9S17fFp_r74-Zl5qOWWqKFypvDZ5Wc8f-RyUL0utjEEjSwkOVFlKaYyrvdK5KpwsNt5o4fL6VdVSLNn1wTum4fc20GS7SD607XzcsCWrNSjI5_-XTB5AnwaiFGo7pti5tLMIdl-mfS_TAtr3MufYp6N_-9qFzf_Qsb0Z-HwEHHnX1sn1PtI_zoCSar_9y4Fq4s_mT0zBUufadpaiDekNtUVbGPEXCFqGpg</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Fukunaga, K</creator><creator>Asano, K</creator><creator>Mao, X-Q</creator><creator>Gao, P-S</creator><creator>Roberts, M.H</creator><creator>Oguma, T</creator><creator>Shiomi, T</creator><creator>Kanazawa, M</creator><creator>Adra, C.N</creator><creator>Shirakawa, T</creator><creator>Hopkin, J.M</creator><creator>Yamaguchi, K</creator><general>Eur Respiratory Soc</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics</title><author>Fukunaga, K ; Asano, K ; Mao, X-Q ; Gao, P-S ; Roberts, M.H ; Oguma, T ; Shiomi, T ; Kanazawa, M ; Adra, C.N ; Shirakawa, T ; Hopkin, J.M ; Yamaguchi, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-655a86c7928f118c206c887699194840a06884499afc67265a45dc973a2fb6f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Alleles</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Asthma - genetics</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Genetics, Population</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - complications</topic><topic>Hypersensitivity, Immediate - diagnosis</topic><topic>Japan</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Mutation, Missense</topic><topic>Pneumology</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single-Stranded Conformational</topic><topic>Receptors, CCR3</topic><topic>Receptors, Chemokine - genetics</topic><topic>United Kingdom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukunaga, K</creatorcontrib><creatorcontrib>Asano, K</creatorcontrib><creatorcontrib>Mao, X-Q</creatorcontrib><creatorcontrib>Gao, P-S</creatorcontrib><creatorcontrib>Roberts, M.H</creatorcontrib><creatorcontrib>Oguma, T</creatorcontrib><creatorcontrib>Shiomi, T</creatorcontrib><creatorcontrib>Kanazawa, M</creatorcontrib><creatorcontrib>Adra, C.N</creatorcontrib><creatorcontrib>Shirakawa, T</creatorcontrib><creatorcontrib>Hopkin, J.M</creatorcontrib><creatorcontrib>Yamaguchi, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukunaga, K</au><au>Asano, K</au><au>Mao, X-Q</au><au>Gao, P-S</au><au>Roberts, M.H</au><au>Oguma, T</au><au>Shiomi, T</au><au>Kanazawa, M</au><au>Adra, C.N</au><au>Shirakawa, T</au><au>Hopkin, J.M</au><au>Yamaguchi, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>17</volume><issue>1</issue><spage>59</spage><epage>63</epage><pages>59-63</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Whole genome scan analyses have revealed that chromosomal region 3p21-24, which contains a gene cluster of CC chemokine receptors such as CCR3, is possibly linked to asthma. Because CCR3 ligands play a pivotal role in the selective recruitment and activation of inflammatory cells in the asthmatic airway, the authors examined whether there is any association between asthma and the CCR3 gene polymorphisms. Three polymorphisms were identified using the single stranded conformational polymorphism method in Japanese (Asian) and British (Caucasian) subjects; one silent mutation T51C and two missense mutations G824A and T971C. These polymorphisms were examined in 391 Japanese subjects (210 asthmatics and 181 nonasthmatic controls) and 234 British subjects (142 asthmatics and 92 nonasthmatic controls). Asthma diagnosis was based on episodic symptoms, documented wheeze, and the presence of reversible airflow limitation. CCR3 T51C demonstrated a significant association with the diagnosis of asthma in the British population (odds ratio 2.35, p<0.01), but not in the Japanese population. Multiple logistic regression analysis also showed that CCR3 T51C was associated with asthma (odds ratio 2.83, p < 0.02), independent of atopic phenotypes such as high levels of total or house dust mite-specific immunoglobulin-E in serum. In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found.</abstract><cop>Leeds</cop><pub>Eur Respiratory Soc</pub><pmid>11307756</pmid><doi>10.1183/09031936.01.17100590</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0903-1936 |
| ispartof | The European respiratory journal, 2001-01, Vol.17 (1), p.59-63 |
| issn | 0903-1936 1399-3003 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77060219 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alleles Asian Continental Ancestry Group - genetics Asthma - genetics Asthma - immunology Biological and medical sciences Chronic obstructive pulmonary disease, asthma European Continental Ancestry Group - genetics Genetics, Population Humans Hypersensitivity, Immediate - complications Hypersensitivity, Immediate - diagnosis Japan Medical sciences Mutation Mutation, Missense Pneumology Polymorphism, Genetic Polymorphism, Restriction Fragment Length Polymorphism, Single-Stranded Conformational Receptors, CCR3 Receptors, Chemokine - genetics United Kingdom |
| title | Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T07%3A06%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20polymorphisms%20of%20CC%20chemokine%20receptor%203%20in%20Japanese%20and%20British%20asthmatics&rft.jtitle=The%20European%20respiratory%20journal&rft.au=Fukunaga,%20K&rft.date=2001-01-01&rft.volume=17&rft.issue=1&rft.spage=59&rft.epage=63&rft.pages=59-63&rft.issn=0903-1936&rft.eissn=1399-3003&rft_id=info:doi/10.1183/09031936.01.17100590&rft_dat=%3Cproquest_cross%3E77060219%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77060219&rft_id=info:pmid/11307756&rfr_iscdi=true |