CXCR3 Chemokine Receptor Distribution in Normal and Inflamed Tissues: Expression on Activated Lymphocytes, Endothelial Cells, and Dendritic Cells
Using new human CXCR3 chemokine receptor–specific monoclonal antibodies, we studied human CXCR3 tissue distribution in lymphoid and nonlymphoid organs, as well as in inflammatory conditions, including rheumatoid arthritis, Hashimoto's thyroiditis, and dermal vasculitis. CXCR3 was expressed by c...
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| Veröffentlicht in: | Laboratory investigation 2001-03, Vol.81 (3), p.409-418 |
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| creator | García-López, María Ángeles Sánchez-Madrid, Francisco Rodríguez-Frade, Jose Miguel Mellado, Mario Acevedo, Agustín García, M Isabel Albar, Juan Pablo Martínez-A, Carlos Marazuela, Mónica |
| description | Using new human CXCR3 chemokine receptor–specific monoclonal antibodies, we studied human CXCR3 tissue distribution in lymphoid and nonlymphoid organs, as well as in inflammatory conditions, including rheumatoid arthritis, Hashimoto's thyroiditis, and dermal vasculitis. CXCR3 was expressed by certain dendritic cell subsets, specifically myeloid-derived CD11c positive cells, not only in those present in normal lymphoid organs, but also in germinal centers generated in inflammatory conditions. CXCR3 expression was also detected in some lymphocyte subsets such as intraepithelial lymphocytes of secondary lymphoid organs and infiltrating lymphocytes in inflammatory conditions. In addition, CXCR3 was constitutively expressed by endothelial cells (EC) of vessels of medium and large caliber but not in small vessels from different organs. Finally, enhanced CXCR3 expression was found in EC and in infiltrating lymphocytes with an activated phenotype in inflammatory diseases. The CXCR3 chemokine receptor may play a role in the regulation of leukocyte migration to inflammatory sites. |
| doi_str_mv | 10.1038/labinvest.3780248 |
| format | Article |
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CXCR3 was expressed by certain dendritic cell subsets, specifically myeloid-derived CD11c positive cells, not only in those present in normal lymphoid organs, but also in germinal centers generated in inflammatory conditions. CXCR3 expression was also detected in some lymphocyte subsets such as intraepithelial lymphocytes of secondary lymphoid organs and infiltrating lymphocytes in inflammatory conditions. In addition, CXCR3 was constitutively expressed by endothelial cells (EC) of vessels of medium and large caliber but not in small vessels from different organs. Finally, enhanced CXCR3 expression was found in EC and in infiltrating lymphocytes with an activated phenotype in inflammatory diseases. The CXCR3 chemokine receptor may play a role in the regulation of leukocyte migration to inflammatory sites.</description><identifier>ISSN: 0023-6837</identifier><identifier>EISSN: 1530-0307</identifier><identifier>DOI: 10.1038/labinvest.3780248</identifier><identifier>PMID: 11310833</identifier><identifier>CODEN: LAINAW</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animals ; Antibodies, Monoclonal ; Antibody Specificity ; Biological and medical sciences ; Cell physiology ; Cells, Cultured ; Chemotaxis, Leukocyte - immunology ; Dendritic Cells - chemistry ; Dendritic Cells - immunology ; Endothelium, Vascular - chemistry ; Endothelium, Vascular - immunology ; Fundamental and applied biological sciences. Psychology ; Humans ; Inflammation ; Kidney - cytology ; Laboratory Medicine ; Lymphocyte Activation - immunology ; Lymphocytes - chemistry ; Lymphocytes - immunology ; Lymphoid Tissue - chemistry ; Lymphoid Tissue - immunology ; Lymphoid Tissue - pathology ; Medicine ; Medicine & Public Health ; Mice ; Molecular and cellular biology ; Motility and taxis ; Pathology ; Receptors, Chemokine - analysis ; Receptors, Chemokine - genetics ; Receptors, Chemokine - immunology ; Receptors, CXCR3 ; Synovitis - immunology ; Synovitis - pathology ; Thyroiditis, Autoimmune - immunology ; Thyroiditis, Autoimmune - pathology ; Transfection ; Vasculitis - immunology ; Vasculitis - pathology</subject><ispartof>Laboratory investigation, 2001-03, Vol.81 (3), p.409-418</ispartof><rights>The United States and Canadian Academy of Pathology, Inc. 2001</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Mar 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-6becdb85f88e7976a388f761a99468a70da8aab4095ace61cfd7c1fad89ff2df3</citedby><cites>FETCH-LOGICAL-c559t-6becdb85f88e7976a388f761a99468a70da8aab4095ace61cfd7c1fad89ff2df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1135232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11310833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-López, María Ángeles</creatorcontrib><creatorcontrib>Sánchez-Madrid, Francisco</creatorcontrib><creatorcontrib>Rodríguez-Frade, Jose Miguel</creatorcontrib><creatorcontrib>Mellado, Mario</creatorcontrib><creatorcontrib>Acevedo, Agustín</creatorcontrib><creatorcontrib>García, M Isabel</creatorcontrib><creatorcontrib>Albar, Juan Pablo</creatorcontrib><creatorcontrib>Martínez-A, Carlos</creatorcontrib><creatorcontrib>Marazuela, Mónica</creatorcontrib><title>CXCR3 Chemokine Receptor Distribution in Normal and Inflamed Tissues: Expression on Activated Lymphocytes, Endothelial Cells, and Dendritic Cells</title><title>Laboratory investigation</title><addtitle>Lab Invest</addtitle><addtitle>Lab Invest</addtitle><description>Using new human CXCR3 chemokine receptor–specific monoclonal antibodies, we studied human CXCR3 tissue distribution in lymphoid and nonlymphoid organs, as well as in inflammatory conditions, including rheumatoid arthritis, Hashimoto's thyroiditis, and dermal vasculitis. 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The CXCR3 chemokine receptor may play a role in the regulation of leukocyte migration to inflammatory sites.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Antibody Specificity</subject><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cells, Cultured</subject><subject>Chemotaxis, Leukocyte - immunology</subject><subject>Dendritic Cells - chemistry</subject><subject>Dendritic Cells - immunology</subject><subject>Endothelium, Vascular - chemistry</subject><subject>Endothelium, Vascular - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Kidney - cytology</subject><subject>Laboratory Medicine</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphocytes - chemistry</subject><subject>Lymphocytes - immunology</subject><subject>Lymphoid Tissue - chemistry</subject><subject>Lymphoid Tissue - immunology</subject><subject>Lymphoid Tissue - pathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Motility and taxis</subject><subject>Pathology</subject><subject>Receptors, Chemokine - analysis</subject><subject>Receptors, Chemokine - genetics</subject><subject>Receptors, Chemokine - immunology</subject><subject>Receptors, CXCR3</subject><subject>Synovitis - immunology</subject><subject>Synovitis - pathology</subject><subject>Thyroiditis, Autoimmune - immunology</subject><subject>Thyroiditis, Autoimmune - pathology</subject><subject>Transfection</subject><subject>Vasculitis - immunology</subject><subject>Vasculitis - pathology</subject><issn>0023-6837</issn><issn>1530-0307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kdGK1DAUhoMo7rj6AF4oQURvnDVp2ib1bumOujAoLCt4V9L0xMnaJt0kXZzH8I3N0LorXiwEAud8_59z8iP0nJITSph438vW2BsI8YRxQbJcPEArWjCyJozwh2hFSMbWpWD8CD0J4YoQmudl8RgdUcooEYyt0O_6e33BcL2Dwf00FvAFKBij8_jMhOhNO0XjLDYWf3F-kD2WtsPnVvdygA5fmhAmCB_w5tfoIYQDms6piuZGxgRs98O4c2ofIbzDG9u5uIPeJJsa-j6VDm5nYDtvolFz8Sl6pGUf4NlyH6NvHzeX9ef19uun8_p0u1ZFUcV12YLqWlFoIYBXvJRMCM1LKqsqL4XkpJNCyjYnVSEVlFTpjiuqZScqrbNOs2P0ZvYdvbtOS8RmMEGlCaQFN4WGc1ISUuYJfHs_WBSUsTwXiXz1H3nlJm_TFk2WpUwqkdME0RlS3oXgQTejN4P0-4aS5hBrcxtrs8SaNC8X46lN_36nWHJMwOsFkEHJXntplQn_ckXGsoRlMxZSx_4AfzfgfY-_mEVWxsnDrenf_h-pXMmD</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>García-López, María Ángeles</creator><creator>Sánchez-Madrid, Francisco</creator><creator>Rodríguez-Frade, Jose Miguel</creator><creator>Mellado, Mario</creator><creator>Acevedo, Agustín</creator><creator>García, M Isabel</creator><creator>Albar, Juan Pablo</creator><creator>Martínez-A, Carlos</creator><creator>Marazuela, Mónica</creator><general>Nature Publishing Group US</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>CXCR3 Chemokine Receptor Distribution in Normal and Inflamed Tissues: Expression on Activated Lymphocytes, Endothelial Cells, and Dendritic Cells</title><author>García-López, María Ángeles ; Sánchez-Madrid, Francisco ; Rodríguez-Frade, Jose Miguel ; Mellado, Mario ; Acevedo, Agustín ; García, M Isabel ; Albar, Juan Pablo ; Martínez-A, Carlos ; Marazuela, Mónica</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-6becdb85f88e7976a388f761a99468a70da8aab4095ace61cfd7c1fad89ff2df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Antibody Specificity</topic><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Cells, Cultured</topic><topic>Chemotaxis, Leukocyte - immunology</topic><topic>Dendritic Cells - chemistry</topic><topic>Dendritic Cells - immunology</topic><topic>Endothelium, Vascular - chemistry</topic><topic>Endothelium, Vascular - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Kidney - cytology</topic><topic>Laboratory Medicine</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphocytes - chemistry</topic><topic>Lymphocytes - immunology</topic><topic>Lymphoid Tissue - chemistry</topic><topic>Lymphoid Tissue - immunology</topic><topic>Lymphoid Tissue - pathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Motility and taxis</topic><topic>Pathology</topic><topic>Receptors, Chemokine - analysis</topic><topic>Receptors, Chemokine - genetics</topic><topic>Receptors, Chemokine - immunology</topic><topic>Receptors, CXCR3</topic><topic>Synovitis - immunology</topic><topic>Synovitis - pathology</topic><topic>Thyroiditis, Autoimmune - immunology</topic><topic>Thyroiditis, Autoimmune - pathology</topic><topic>Transfection</topic><topic>Vasculitis - immunology</topic><topic>Vasculitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-López, María Ángeles</creatorcontrib><creatorcontrib>Sánchez-Madrid, Francisco</creatorcontrib><creatorcontrib>Rodríguez-Frade, Jose Miguel</creatorcontrib><creatorcontrib>Mellado, Mario</creatorcontrib><creatorcontrib>Acevedo, Agustín</creatorcontrib><creatorcontrib>García, M Isabel</creatorcontrib><creatorcontrib>Albar, Juan Pablo</creatorcontrib><creatorcontrib>Martínez-A, Carlos</creatorcontrib><creatorcontrib>Marazuela, Mónica</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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CXCR3 was expressed by certain dendritic cell subsets, specifically myeloid-derived CD11c positive cells, not only in those present in normal lymphoid organs, but also in germinal centers generated in inflammatory conditions. CXCR3 expression was also detected in some lymphocyte subsets such as intraepithelial lymphocytes of secondary lymphoid organs and infiltrating lymphocytes in inflammatory conditions. In addition, CXCR3 was constitutively expressed by endothelial cells (EC) of vessels of medium and large caliber but not in small vessels from different organs. Finally, enhanced CXCR3 expression was found in EC and in infiltrating lymphocytes with an activated phenotype in inflammatory diseases. 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| ispartof | Laboratory investigation, 2001-03, Vol.81 (3), p.409-418 |
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| subjects | Animals Antibodies, Monoclonal Antibody Specificity Biological and medical sciences Cell physiology Cells, Cultured Chemotaxis, Leukocyte - immunology Dendritic Cells - chemistry Dendritic Cells - immunology Endothelium, Vascular - chemistry Endothelium, Vascular - immunology Fundamental and applied biological sciences. Psychology Humans Inflammation Kidney - cytology Laboratory Medicine Lymphocyte Activation - immunology Lymphocytes - chemistry Lymphocytes - immunology Lymphoid Tissue - chemistry Lymphoid Tissue - immunology Lymphoid Tissue - pathology Medicine Medicine & Public Health Mice Molecular and cellular biology Motility and taxis Pathology Receptors, Chemokine - analysis Receptors, Chemokine - genetics Receptors, Chemokine - immunology Receptors, CXCR3 Synovitis - immunology Synovitis - pathology Thyroiditis, Autoimmune - immunology Thyroiditis, Autoimmune - pathology Transfection Vasculitis - immunology Vasculitis - pathology |
| title | CXCR3 Chemokine Receptor Distribution in Normal and Inflamed Tissues: Expression on Activated Lymphocytes, Endothelial Cells, and Dendritic Cells |
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