Excretion of Cytomegalovirus in Semen Associated with HTLV-III Seropositivity in Asymptomatic Homosexual Men
We studied 56 asymptomatic homosexual male volunteers in Pittsburgh for 11/2 yr for relationships between cytomegalovirus (CMV) and human T‐lymphotropic virus type III (HTLV‐III) infections. CMV was most frequently isolated from semen (8%) as compared with throat washings (5.9%) and urine (0%) on in...
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| Veröffentlicht in: | Journal of medical virology 1986-09, Vol.20 (1), p.17-22 |
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| creator | Rinaldo Jr, Charles R. Kingsley, Lawrence A. Lyter, David W. Bodner, Anne J. Weiss, Stanley H. Carl Saxinger, W. |
| description | We studied 56 asymptomatic homosexual male volunteers in Pittsburgh for 11/2 yr for relationships between cytomegalovirus (CMV) and human T‐lymphotropic virus type III (HTLV‐III) infections. CMV was most frequently isolated from semen (8%) as compared with throat washings (5.9%) and urine (0%) on initial testing of CMV‐seropositive subjects. Other viruses commonly isolated from immunosuppressed patients (herpes simplex virus, adenovirus) were rarely detected in this cohort. Seropositivity to HTLV‐III was significantly associated with isolation of CMV from semen in our asymptomatic cohort (odds ratio = 9.5, p = .008). These results suggest that HTLV‐III infection is associated with selective, temporal activation of CMV in the genital tract of asymptomatic homosexual men. |
| doi_str_mv | 10.1002/jmv.1890200104 |
| format | Article |
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CMV was most frequently isolated from semen (8%) as compared with throat washings (5.9%) and urine (0%) on initial testing of CMV‐seropositive subjects. Other viruses commonly isolated from immunosuppressed patients (herpes simplex virus, adenovirus) were rarely detected in this cohort. Seropositivity to HTLV‐III was significantly associated with isolation of CMV from semen in our asymptomatic cohort (odds ratio = 9.5, p = .008). These results suggest that HTLV‐III infection is associated with selective, temporal activation of CMV in the genital tract of asymptomatic homosexual men.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.1890200104</identifier><identifier>PMID: 3020166</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Adolescent ; Adult ; AIDS ; AIDS/HIV ; Antibodies, Viral - analysis ; Biological and medical sciences ; Cytomegalovirus - isolation & purification ; Cytomegalovirus Infections - complications ; Fundamental and applied biological sciences. 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Med. Virol</addtitle><description>We studied 56 asymptomatic homosexual male volunteers in Pittsburgh for 11/2 yr for relationships between cytomegalovirus (CMV) and human T‐lymphotropic virus type III (HTLV‐III) infections. CMV was most frequently isolated from semen (8%) as compared with throat washings (5.9%) and urine (0%) on initial testing of CMV‐seropositive subjects. Other viruses commonly isolated from immunosuppressed patients (herpes simplex virus, adenovirus) were rarely detected in this cohort. Seropositivity to HTLV‐III was significantly associated with isolation of CMV from semen in our asymptomatic cohort (odds ratio = 9.5, p = .008). These results suggest that HTLV‐III infection is associated with selective, temporal activation of CMV in the genital tract of asymptomatic homosexual men.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS</subject><subject>AIDS/HIV</subject><subject>Antibodies, Viral - analysis</subject><subject>Biological and medical sciences</subject><subject>Cytomegalovirus - isolation & purification</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>genital tract</subject><subject>herpesvirus</subject><subject>HIV - immunology</subject><subject>HIV Antibodies</subject><subject>Homosexuality</subject><subject>Humans</subject><subject>Male</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Semen - microbiology</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFv0zAUxi0EGmVw5YbkA-KW7jl27ORYlbF26saBsXGzbNcBjyQudtI1_z2uWhVx2ukdvt_3vaf3IfSewJQA5BeP7XZKygpyAALsBZoQqHhWgSAv0QQI4xnnpHiN3sT4CABlledn6IwmnnA-Qc3lzgTbO99hX-P52PvW_lSN37owROw6_M22tsOzGL1xqrdr_OT6X3hxt7rPlstlkoPf-Oh6t3X9uDfM4thuUozqncEL3_pod4Nq8I3t3qJXtWqifXec5-j7l8u7-SJbfb1azmerzDBasv3xBiohtFBUAzBDDLOszqnNta5KmqjCMi1qVWoghS61yCEXayaKtQGq6Dn6dMjdBP9nsLGXrYvGNo3qrB-iFAI4ACfPgoSxghacJ3B6AE3wMQZby01wrQqjJCD3PcjUg_zXQzJ8OCYPurXrE358fNI_HnUVjWrqoDrj4gkTVVWWRCSsOmBPrrHjM0vl9c39fydkB6-Lvd2dvCr8llxQUciH2yv54zNh5Yo8yFv6FzlosAs</recordid><startdate>198609</startdate><enddate>198609</enddate><creator>Rinaldo Jr, Charles R.</creator><creator>Kingsley, Lawrence A.</creator><creator>Lyter, David W.</creator><creator>Bodner, Anne J.</creator><creator>Weiss, Stanley H.</creator><creator>Carl Saxinger, W.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198609</creationdate><title>Excretion of Cytomegalovirus in Semen Associated with HTLV-III Seropositivity in Asymptomatic Homosexual Men</title><author>Rinaldo Jr, Charles R. ; Kingsley, Lawrence A. ; Lyter, David W. ; Bodner, Anne J. ; Weiss, Stanley H. ; Carl Saxinger, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4384-907c0977b7a3b004c1c4e4f23e2bb983c435e4b7fa8b015b8b72027d475dc03a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS</topic><topic>AIDS/HIV</topic><topic>Antibodies, Viral - analysis</topic><topic>Biological and medical sciences</topic><topic>Cytomegalovirus - isolation & purification</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>genital tract</topic><topic>herpesvirus</topic><topic>HIV - immunology</topic><topic>HIV Antibodies</topic><topic>Homosexuality</topic><topic>Humans</topic><topic>Male</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Semen - microbiology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rinaldo Jr, Charles R.</creatorcontrib><creatorcontrib>Kingsley, Lawrence A.</creatorcontrib><creatorcontrib>Lyter, David W.</creatorcontrib><creatorcontrib>Bodner, Anne J.</creatorcontrib><creatorcontrib>Weiss, Stanley H.</creatorcontrib><creatorcontrib>Carl Saxinger, W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rinaldo Jr, Charles R.</au><au>Kingsley, Lawrence A.</au><au>Lyter, David W.</au><au>Bodner, Anne J.</au><au>Weiss, Stanley H.</au><au>Carl Saxinger, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excretion of Cytomegalovirus in Semen Associated with HTLV-III Seropositivity in Asymptomatic Homosexual Men</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>1986-09</date><risdate>1986</risdate><volume>20</volume><issue>1</issue><spage>17</spage><epage>22</epage><pages>17-22</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>We studied 56 asymptomatic homosexual male volunteers in Pittsburgh for 11/2 yr for relationships between cytomegalovirus (CMV) and human T‐lymphotropic virus type III (HTLV‐III) infections. CMV was most frequently isolated from semen (8%) as compared with throat washings (5.9%) and urine (0%) on initial testing of CMV‐seropositive subjects. Other viruses commonly isolated from immunosuppressed patients (herpes simplex virus, adenovirus) were rarely detected in this cohort. Seropositivity to HTLV‐III was significantly associated with isolation of CMV from semen in our asymptomatic cohort (odds ratio = 9.5, p = .008). These results suggest that HTLV‐III infection is associated with selective, temporal activation of CMV in the genital tract of asymptomatic homosexual men.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3020166</pmid><doi>10.1002/jmv.1890200104</doi><tpages>6</tpages></addata></record> |
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| subjects | Acquired Immunodeficiency Syndrome - complications Adolescent Adult AIDS AIDS/HIV Antibodies, Viral - analysis Biological and medical sciences Cytomegalovirus - isolation & purification Cytomegalovirus Infections - complications Fundamental and applied biological sciences. Psychology genital tract herpesvirus HIV - immunology HIV Antibodies Homosexuality Humans Male Microbiology Middle Aged Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Semen - microbiology Virology |
| title | Excretion of Cytomegalovirus in Semen Associated with HTLV-III Seropositivity in Asymptomatic Homosexual Men |
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