Differential helper and effector responses of Lyt-2+ T cells to H-2Kb mutant (Kbm) determinants and the appearance of thymic influence on anti-Kbm CTL responsiveness

The goal of this study was to assess and compare the allorecognition requirements for eliciting Lyt-2+ helper and effector functions from primary T cell populations. By using interleukin 2 (IL 2) secretion as a measure of T helper (Th) function, and cytolytic T lymphocyte (CTL) generation as a measu...

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Veröffentlicht in:	The Journal of immunology (1950) 1986-11, Vol.137 (9), p.2740-2747
Hauptverfasser:	Mizuochi, T, Munitz, TI, McCarthy, SA, Andrysiak, PM, Kung, J, Gress, RE, Singer, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Antigens, Differentiation, T-Lymphocyte Antigens, Ly - immunology Antigens, Surface - immunology Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology H-2 Antigens - genetics H-2 Antigens - immunology Immunobiology Interleukin-2 - secretion Mice Mutation Organs and cells involved in the immune response Spleen - immunology T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Helper-Inducer - immunology Thymus Gland - physiology
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