Perfusion Brain SPECT and Statistical Parametric Mapping Analysis Indicate That Apathy Is a Cingulate Syndrome: A Study in Alzheimer's Disease and Nondemented Patients
Apathy is the most frequent behavioral symptom in Alzheimer's disease and is also frequently reported in other brain organic disorders occurring in the elderly. Based on the literature, we hypothesized that apathy was related to an anterior cingulate hypofunction. Forty-one subjects were studie...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2001-05, Vol.13 (5), p.896-902 |
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| creator | Migneco, O. Benoit, M. Koulibaly, P.M. Dygai, I. Bertogliati, C. Desvignes, P. Robert, P.H. Malandain, G. Bussiere, F. Darcourt, J. |
| description | Apathy is the most frequent behavioral symptom in Alzheimer's disease and is also frequently reported in other brain organic disorders occurring in the elderly. Based on the literature, we hypothesized that apathy was related to an anterior cingulate hypofunction. Forty-one subjects were studied. According to ICD 10 diagnostic criteria, 28 patients had Alzheimer dementia (demented: diagnostic group 1), and 13 had organic personality disorders or mild cognitive impairment not attributable to dementia (nondemented: diagnostic group 2). Apathy was evaluated by the Neuro-Psychiatric Inventory. As a result each diagnostic group was divided into two symptomatic subgroups: apathetic or nonapathetic. Brain perfusion was measured by 99mTc-labeled bicisate (ECD) brain SPECT and the images were compared using Statistical Parametric Mapping (SPM96). We began by comparing apathetic vs nonapathetic patients, whatever their diagnostic group (whole population), then analyzed them within each group. Twenty-one subjects were apathetic (14 in group 1 and 7 in group 2) and 20 were not (14 in group 1 and 6 in group 2). For the whole population, the Z map showed a significant decrease in ECD uptake for the apathetic patients in the anterior cingulate (P < 0.002) bilaterally. This area was also identified as hypoactive by SPM analysis in the demented (P < 0.035) and in the nondemented (P < 0.02) apathetic patient groups. Finally, conjunction analysis indicated that the anterior cingulate was the common hypoactive structure of the two apathetic subgroups (Z = 4.35, P < 0.0009). These results point to a close relationship between apathy and the anterior cingulate region. |
| doi_str_mv | 10.1006/nimg.2000.0741 |
| format | Article |
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Based on the literature, we hypothesized that apathy was related to an anterior cingulate hypofunction. Forty-one subjects were studied. According to ICD 10 diagnostic criteria, 28 patients had Alzheimer dementia (demented: diagnostic group 1), and 13 had organic personality disorders or mild cognitive impairment not attributable to dementia (nondemented: diagnostic group 2). Apathy was evaluated by the Neuro-Psychiatric Inventory. As a result each diagnostic group was divided into two symptomatic subgroups: apathetic or nonapathetic. Brain perfusion was measured by 99mTc-labeled bicisate (ECD) brain SPECT and the images were compared using Statistical Parametric Mapping (SPM96). We began by comparing apathetic vs nonapathetic patients, whatever their diagnostic group (whole population), then analyzed them within each group. Twenty-one subjects were apathetic (14 in group 1 and 7 in group 2) and 20 were not (14 in group 1 and 6 in group 2). For the whole population, the Z map showed a significant decrease in ECD uptake for the apathetic patients in the anterior cingulate (P < 0.002) bilaterally. This area was also identified as hypoactive by SPM analysis in the demented (P < 0.035) and in the nondemented (P < 0.02) apathetic patient groups. Finally, conjunction analysis indicated that the anterior cingulate was the common hypoactive structure of the two apathetic subgroups (Z = 4.35, P < 0.0009). These results point to a close relationship between apathy and the anterior cingulate region.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1006/nimg.2000.0741</identifier><identifier>PMID: 11304085</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Apathy ; Brain - blood supply ; Brain - diagnostic imaging ; Brain Mapping ; cingulate ; Cognitive ability ; Dementia ; Dementia disorders ; ECD ; Emotional behavior ; Female ; Geriatrics ; Gyrus Cinguli - blood supply ; Gyrus Cinguli - diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Male ; Mathematical Computing ; Motivation ; Neurodegenerative diseases ; Neuropsychological Tests ; Perfusion ; Reference Values ; Regional Blood Flow - physiology ; Single photon emission computed tomography ; statistical parametric mapping ; Statistics ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>NeuroImage (Orlando, Fla.), 2001-05, Vol.13 (5), p.896-902</ispartof><rights>2001 Academic Press</rights><rights>Copyright 2001 Academic Press.</rights><rights>2001. Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-602c897e409375fcf4b27e83d87e7597fd4c23848a5215c5670a60621a535bcc3</citedby><cites>FETCH-LOGICAL-c370t-602c897e409375fcf4b27e83d87e7597fd4c23848a5215c5670a60621a535bcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2218091096?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11304085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Migneco, O.</creatorcontrib><creatorcontrib>Benoit, M.</creatorcontrib><creatorcontrib>Koulibaly, P.M.</creatorcontrib><creatorcontrib>Dygai, I.</creatorcontrib><creatorcontrib>Bertogliati, C.</creatorcontrib><creatorcontrib>Desvignes, P.</creatorcontrib><creatorcontrib>Robert, P.H.</creatorcontrib><creatorcontrib>Malandain, G.</creatorcontrib><creatorcontrib>Bussiere, F.</creatorcontrib><creatorcontrib>Darcourt, J.</creatorcontrib><title>Perfusion Brain SPECT and Statistical Parametric Mapping Analysis Indicate That Apathy Is a Cingulate Syndrome: A Study in Alzheimer's Disease and Nondemented Patients</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Apathy is the most frequent behavioral symptom in Alzheimer's disease and is also frequently reported in other brain organic disorders occurring in the elderly. Based on the literature, we hypothesized that apathy was related to an anterior cingulate hypofunction. Forty-one subjects were studied. According to ICD 10 diagnostic criteria, 28 patients had Alzheimer dementia (demented: diagnostic group 1), and 13 had organic personality disorders or mild cognitive impairment not attributable to dementia (nondemented: diagnostic group 2). Apathy was evaluated by the Neuro-Psychiatric Inventory. As a result each diagnostic group was divided into two symptomatic subgroups: apathetic or nonapathetic. Brain perfusion was measured by 99mTc-labeled bicisate (ECD) brain SPECT and the images were compared using Statistical Parametric Mapping (SPM96). We began by comparing apathetic vs nonapathetic patients, whatever their diagnostic group (whole population), then analyzed them within each group. Twenty-one subjects were apathetic (14 in group 1 and 7 in group 2) and 20 were not (14 in group 1 and 6 in group 2). For the whole population, the Z map showed a significant decrease in ECD uptake for the apathetic patients in the anterior cingulate (P < 0.002) bilaterally. This area was also identified as hypoactive by SPM analysis in the demented (P < 0.035) and in the nondemented (P < 0.02) apathetic patient groups. Finally, conjunction analysis indicated that the anterior cingulate was the common hypoactive structure of the two apathetic subgroups (Z = 4.35, P < 0.0009). These results point to a close relationship between apathy and the anterior cingulate region.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Apathy</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Mapping</subject><subject>cingulate</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>ECD</subject><subject>Emotional behavior</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Gyrus Cinguli - blood supply</subject><subject>Gyrus Cinguli - diagnostic imaging</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Mathematical Computing</subject><subject>Motivation</subject><subject>Neurodegenerative diseases</subject><subject>Neuropsychological Tests</subject><subject>Perfusion</subject><subject>Reference Values</subject><subject>Regional Blood Flow - physiology</subject><subject>Single photon emission computed tomography</subject><subject>statistical parametric mapping</subject><subject>Statistics</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kV-L1DAUxYso7h999VECgj51TNKmSX2r46oDqw7M-Bwyye1OljatSSp0v5Bf09QZEASf7oX7u-fAOVn2guAVwbh662x_t6IY4xXmJXmUXRJcs7xmnD5edlbkgpD6IrsK4T5RNSnF0-yCkAKXWLDL7NcWfDsFOzj03ivr0G57s94j5QzaRRVtiFarDm2VVz1EbzX6osbRujvUONXNwQa0cSYxEdD-qCJqRhWPM9oEpNA6cVO3nHazM37o4R1qku5kZpSsmu7hCLYH_yagDzaACvDH-OvgDPTgIphkHG3awrPsSau6AM_P8zr7_vFmv_6c3377tFk3t7kuOI55hakWNYcS1wVnrW7LA-UgCiM4cFbz1pSaFqIUilHCNKs4VhWuKFGsYAeti-vs9Ul39MOPCUKUvQ0auk45GKYgOcdMCCwS-Oof8H6YfMokSEqJSEnjukrU6kRpP4TgoZWjt73ysyRYLgXKpUC5FCiXAtPDy7PsdOjB_MXPjSVAnABIKfy04GXQKSENxnrQUZrB_k_7Nyi5qc0</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>Migneco, O.</creator><creator>Benoit, M.</creator><creator>Koulibaly, P.M.</creator><creator>Dygai, I.</creator><creator>Bertogliati, C.</creator><creator>Desvignes, P.</creator><creator>Robert, P.H.</creator><creator>Malandain, G.</creator><creator>Bussiere, F.</creator><creator>Darcourt, J.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>Perfusion Brain SPECT and Statistical Parametric Mapping Analysis Indicate That Apathy Is a Cingulate Syndrome: A Study in Alzheimer's Disease and Nondemented Patients</title><author>Migneco, O. ; Benoit, M. ; Koulibaly, P.M. ; Dygai, I. ; Bertogliati, C. ; Desvignes, P. ; Robert, P.H. ; Malandain, G. ; Bussiere, F. ; Darcourt, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-602c897e409375fcf4b27e83d87e7597fd4c23848a5215c5670a60621a535bcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>Apathy</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Mapping</topic><topic>cingulate</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>ECD</topic><topic>Emotional behavior</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Gyrus Cinguli - blood supply</topic><topic>Gyrus Cinguli - diagnostic imaging</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Mathematical Computing</topic><topic>Motivation</topic><topic>Neurodegenerative diseases</topic><topic>Neuropsychological Tests</topic><topic>Perfusion</topic><topic>Reference Values</topic><topic>Regional Blood Flow - physiology</topic><topic>Single photon emission computed tomography</topic><topic>statistical parametric mapping</topic><topic>Statistics</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Migneco, O.</creatorcontrib><creatorcontrib>Benoit, M.</creatorcontrib><creatorcontrib>Koulibaly, P.M.</creatorcontrib><creatorcontrib>Dygai, I.</creatorcontrib><creatorcontrib>Bertogliati, C.</creatorcontrib><creatorcontrib>Desvignes, P.</creatorcontrib><creatorcontrib>Robert, P.H.</creatorcontrib><creatorcontrib>Malandain, G.</creatorcontrib><creatorcontrib>Bussiere, F.</creatorcontrib><creatorcontrib>Darcourt, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Migneco, O.</au><au>Benoit, M.</au><au>Koulibaly, P.M.</au><au>Dygai, I.</au><au>Bertogliati, C.</au><au>Desvignes, P.</au><au>Robert, P.H.</au><au>Malandain, G.</au><au>Bussiere, F.</au><au>Darcourt, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perfusion Brain SPECT and Statistical Parametric Mapping Analysis Indicate That Apathy Is a Cingulate Syndrome: A Study in Alzheimer's Disease and Nondemented Patients</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>13</volume><issue>5</issue><spage>896</spage><epage>902</epage><pages>896-902</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Apathy is the most frequent behavioral symptom in Alzheimer's disease and is also frequently reported in other brain organic disorders occurring in the elderly. Based on the literature, we hypothesized that apathy was related to an anterior cingulate hypofunction. Forty-one subjects were studied. According to ICD 10 diagnostic criteria, 28 patients had Alzheimer dementia (demented: diagnostic group 1), and 13 had organic personality disorders or mild cognitive impairment not attributable to dementia (nondemented: diagnostic group 2). Apathy was evaluated by the Neuro-Psychiatric Inventory. As a result each diagnostic group was divided into two symptomatic subgroups: apathetic or nonapathetic. Brain perfusion was measured by 99mTc-labeled bicisate (ECD) brain SPECT and the images were compared using Statistical Parametric Mapping (SPM96). We began by comparing apathetic vs nonapathetic patients, whatever their diagnostic group (whole population), then analyzed them within each group. Twenty-one subjects were apathetic (14 in group 1 and 7 in group 2) and 20 were not (14 in group 1 and 6 in group 2). For the whole population, the Z map showed a significant decrease in ECD uptake for the apathetic patients in the anterior cingulate (P < 0.002) bilaterally. This area was also identified as hypoactive by SPM analysis in the demented (P < 0.035) and in the nondemented (P < 0.02) apathetic patient groups. Finally, conjunction analysis indicated that the anterior cingulate was the common hypoactive structure of the two apathetic subgroups (Z = 4.35, P < 0.0009). These results point to a close relationship between apathy and the anterior cingulate region.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11304085</pmid><doi>10.1006/nimg.2000.0741</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - physiopathology Alzheimer's disease Apathy Brain - blood supply Brain - diagnostic imaging Brain Mapping cingulate Cognitive ability Dementia Dementia disorders ECD Emotional behavior Female Geriatrics Gyrus Cinguli - blood supply Gyrus Cinguli - diagnostic imaging Humans Image Processing, Computer-Assisted Male Mathematical Computing Motivation Neurodegenerative diseases Neuropsychological Tests Perfusion Reference Values Regional Blood Flow - physiology Single photon emission computed tomography statistical parametric mapping Statistics Tomography, Emission-Computed, Single-Photon |
| title | Perfusion Brain SPECT and Statistical Parametric Mapping Analysis Indicate That Apathy Is a Cingulate Syndrome: A Study in Alzheimer's Disease and Nondemented Patients |
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