Dominant negative mutants of mitogen-activated protein kinase pathway

One of the gene families most commonly found mutated in human tumors is the ras gene family. Ras has been shown to regulate several pathways that contribute to cellular transformation, including the Rac and Rho pathways and the Raf-MEK-MAPK pathway (MEK, MAPK/ERK kinase; MAPK, mitogen activated prot...

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Veröffentlicht in:Methods in Enzymology 2001, Vol.332, p.353-367
Hauptverfasser: Arboleda, M.Jane, Eberwein, Derek, Hibner, Barbara, Lyons, John F.
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Sprache:eng
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