Pathways to neuronal injury and apoptosis in HIV-associated dementia

Human immunodeficiency virus-1 (HIV-1) can induce dementia with alarming occurrence worldwide. The mechanism remains poorly understood, but discovery in brain of HIV-1-binding sites (chemokine receptors) provides new insights. HIV-1 infects macrophages and microglia, but not neurons, although neuron...

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Veröffentlicht in:	Nature (London) 2001-04, Vol.410 (6831), p.988-994
Hauptverfasser:	Kaul, Marcus, Garden, Gwenn A., Lipton, Stuart A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Dementia Complex - drug therapy AIDS Dementia Complex - pathology AIDS Dementia Complex - prevention & control AIDS Dementia Complex - virology Apoptosis Astrocytes - physiology Astrocytes - virology Brain - pathology Brain - physiopathology Brain - virology Dementia Dementia disorders HIV HIV-1 - pathogenicity HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humanities and Social Sciences Humans Macrophages - physiology Macrophages - virology Microglia - physiology Microglia - virology multidisciplinary neuronal injury Neurons Neurons - pathology Neurons - physiology Receptors, Chemokine - physiology Receptors, HIV - physiology Retroviridae Proteins - metabolism review-article Science Science (multidisciplinary) Toxins
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