Mutant sensory cilia in the nematode Caenorhabditis elegans
Eight classes of chemosensory neurons in C. elegans fill with fluorescein when living animals are placed in a dye solution. Fluorescein enters the neurons through their exposed sensory cilia. Mutations in 14 genes prevent dye uptake and disrupt chemosensory behaviors. Each of these genes affects the...
Gespeichert in:
| Veröffentlicht in: | Developmental biology 1986-10, Vol.117 (2), p.456-487 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 487 |
|---|---|
| container_issue | 2 |
| container_start_page | 456 |
| container_title | Developmental biology |
| container_volume | 117 |
| creator | Perkins, Lizabeth A. Hedgecock, Edward M. Thomson, J.Nichol Culotti, Joseph G. |
| description | Eight classes of chemosensory neurons in
C. elegans fill with fluorescein when living animals are placed in a dye solution. Fluorescein enters the neurons through their exposed sensory cilia. Mutations in 14 genes prevent dye uptake and disrupt chemosensory behaviors. Each of these genes affects the ultrastructure of the chemosensory cilia or their accessory cells. In each case, the cilia are shorter or less exposed than normal, suggesting that dye contact is the principal factor under selection. Ten genes affect many or all of the sensory cilia in the head. The
daf-19 (m86) mutation eliminates all cilia, leaving only occasional centrioles in the dendrites. The cilia in
che-13 (e1805), osm-1 (p808), osm-5 (p813), and
osm-6 (p811) mutants have normal transition zones and severely shortened axonemes. Doublet-microtubules, attached to the membrane by Y links, assemble ectopically proximal to the cilia in these mutants. The amphid cilia in
che-11 (e1810) are irregular in diameter and contain dark ground material in the middle of the axonemes. Certain mechanocilia are also affected. The amphid cilia in
che-10 (e1809) apparently degenerate, leaving dendrites with bulb-shaped endings filled with dark ground material. The mechanocilia lack striated rootlets. Cilia defects have also been found in
che-2, che-3, and
daf-10 mutants. The
osm-3 (p802) mutation specifically eliminates the distal segment of the amphid cilia. Mutations in three genes affect sensillar support cells. The
che-12 (e1812) mutation eliminates matrix material normally secreted by the amphid sheath cell. The
che-14 (e1960) mutation disrupts the joining of the amphid sheath and socket cells to form the receptor channel. A similar defect has been observed in
daf-6 mutants. Four additional genes affect specific classes of ciliated sensory neurons. The
mec-1 and
mec-8 (e398) mutations disrupt the fasciculation of the amphid cilia. The
cat-6 (e1861) mutation disrupts the tubular bodies of the CEP mechanocilia. A cryophilic thermotaxis mutant,
ttx-1 (p767), lacks fingers on the AFD dendrite, suggesting this neuron is thermosensory. |
| doi_str_mv | 10.1016/0012-1606(86)90314-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77057326</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0012160686903143</els_id><sourcerecordid>77057326</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-a011d54e37eac39e4acbbdeaa2b02e019fca3fa1b9d20463e5998ba3f884640b3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78AVHoQUQP1UmTpimCIItfoHhQwVuYplONdNM16Qr-e7vuskdPA_M-7zA8jB1wOOPA1TkAz1KuQJ1odVqC4DIVa2zEoczTXMm3dTZaIVtsO8ZPABBai022mclMK52N2MXjrEffJ5F87MJPYl3rMHE-6T8o8TTBvqspGSP5LnxgVbvexYRaekcfd9lGg22kveXcYa831y_ju_Th6fZ-fPWQWlnwPkXgvM4liYLQipIk2qqqCTGrICPgZWNRNMirss5AKkF5WepqWGktlYRK7LDjxd1p6L5mFHszcdFS26KnbhZNUUBeiEwNoFyANnQxBmrMNLgJhh_DwcydmbkQMxditDJ_zowYaofL-7NqQvWqtJQ05EfLHKPFtgnorYsrTIOUAHNsf4E12Bl8DwPy-qwLrnKRD-HlIqRB1LejYKJ15C3VLpDtTd25_5_8BTxxj6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77057326</pqid></control><display><type>article</type><title>Mutant sensory cilia in the nematode Caenorhabditis elegans</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Perkins, Lizabeth A. ; Hedgecock, Edward M. ; Thomson, J.Nichol ; Culotti, Joseph G.</creator><creatorcontrib>Perkins, Lizabeth A. ; Hedgecock, Edward M. ; Thomson, J.Nichol ; Culotti, Joseph G.</creatorcontrib><description>Eight classes of chemosensory neurons in
C. elegans fill with fluorescein when living animals are placed in a dye solution. Fluorescein enters the neurons through their exposed sensory cilia. Mutations in 14 genes prevent dye uptake and disrupt chemosensory behaviors. Each of these genes affects the ultrastructure of the chemosensory cilia or their accessory cells. In each case, the cilia are shorter or less exposed than normal, suggesting that dye contact is the principal factor under selection. Ten genes affect many or all of the sensory cilia in the head. The
daf-19 (m86) mutation eliminates all cilia, leaving only occasional centrioles in the dendrites. The cilia in
che-13 (e1805), osm-1 (p808), osm-5 (p813), and
osm-6 (p811) mutants have normal transition zones and severely shortened axonemes. Doublet-microtubules, attached to the membrane by Y links, assemble ectopically proximal to the cilia in these mutants. The amphid cilia in
che-11 (e1810) are irregular in diameter and contain dark ground material in the middle of the axonemes. Certain mechanocilia are also affected. The amphid cilia in
che-10 (e1809) apparently degenerate, leaving dendrites with bulb-shaped endings filled with dark ground material. The mechanocilia lack striated rootlets. Cilia defects have also been found in
che-2, che-3, and
daf-10 mutants. The
osm-3 (p802) mutation specifically eliminates the distal segment of the amphid cilia. Mutations in three genes affect sensillar support cells. The
che-12 (e1812) mutation eliminates matrix material normally secreted by the amphid sheath cell. The
che-14 (e1960) mutation disrupts the joining of the amphid sheath and socket cells to form the receptor channel. A similar defect has been observed in
daf-6 mutants. Four additional genes affect specific classes of ciliated sensory neurons. The
mec-1 and
mec-8 (e398) mutations disrupt the fasciculation of the amphid cilia. The
cat-6 (e1861) mutation disrupts the tubular bodies of the CEP mechanocilia. A cryophilic thermotaxis mutant,
ttx-1 (p767), lacks fingers on the AFD dendrite, suggesting this neuron is thermosensory.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/0012-1606(86)90314-3</identifier><identifier>PMID: 2428682</identifier><identifier>CODEN: DEBIAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>ANALISIS ; ANALYSE ; ANALYSIS ; Animals ; Behavior, Animal - physiology ; Biological and medical sciences ; Body Temperature Regulation ; Caenorhabditis - anatomy & histology ; Caenorhabditis - genetics ; Caenorhabditis - physiology ; Chemoreceptor Cells - physiology ; Chemoreceptor Cells - ultrastructure ; Cilia - physiology ; Cilia - ultrastructure ; Classical genetics, quantitative genetics, hybrids ; CYTOPLASMIC ORGANELLES ; Fluorescein-5-isothiocyanate ; Fluoresceins - metabolism ; Fundamental and applied biological sciences. Psychology ; GENETICA ; GENETICS ; Genetics of eukaryotes. Biological and molecular evolution ; GENETIQUE ; Invertebrata ; Ion Channels - physiology ; Mechanoreceptors - physiology ; Mechanoreceptors - ultrastructure ; Microscopy, Electron ; MOUVEMENT ; MOVEMENT ; MOVIMIENTO ; MUTACION ; MUTATION ; NEMATODE ; NEMATODES ; NEMATODOS ; ORGANITE CELLULAIRE ; ORGANULOS CITOPLASMATICOS ; Sensory Receptor Cells - physiology ; Sensory Receptor Cells - ultrastructure ; Sexual Behavior, Animal - physiology ; Space life sciences ; Thiocyanates - metabolism</subject><ispartof>Developmental biology, 1986-10, Vol.117 (2), p.456-487</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-a011d54e37eac39e4acbbdeaa2b02e019fca3fa1b9d20463e5998ba3f884640b3</citedby><cites>FETCH-LOGICAL-c471t-a011d54e37eac39e4acbbdeaa2b02e019fca3fa1b9d20463e5998ba3f884640b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0012160686903143$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8044002$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2428682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perkins, Lizabeth A.</creatorcontrib><creatorcontrib>Hedgecock, Edward M.</creatorcontrib><creatorcontrib>Thomson, J.Nichol</creatorcontrib><creatorcontrib>Culotti, Joseph G.</creatorcontrib><title>Mutant sensory cilia in the nematode Caenorhabditis elegans</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>Eight classes of chemosensory neurons in
C. elegans fill with fluorescein when living animals are placed in a dye solution. Fluorescein enters the neurons through their exposed sensory cilia. Mutations in 14 genes prevent dye uptake and disrupt chemosensory behaviors. Each of these genes affects the ultrastructure of the chemosensory cilia or their accessory cells. In each case, the cilia are shorter or less exposed than normal, suggesting that dye contact is the principal factor under selection. Ten genes affect many or all of the sensory cilia in the head. The
daf-19 (m86) mutation eliminates all cilia, leaving only occasional centrioles in the dendrites. The cilia in
che-13 (e1805), osm-1 (p808), osm-5 (p813), and
osm-6 (p811) mutants have normal transition zones and severely shortened axonemes. Doublet-microtubules, attached to the membrane by Y links, assemble ectopically proximal to the cilia in these mutants. The amphid cilia in
che-11 (e1810) are irregular in diameter and contain dark ground material in the middle of the axonemes. Certain mechanocilia are also affected. The amphid cilia in
che-10 (e1809) apparently degenerate, leaving dendrites with bulb-shaped endings filled with dark ground material. The mechanocilia lack striated rootlets. Cilia defects have also been found in
che-2, che-3, and
daf-10 mutants. The
osm-3 (p802) mutation specifically eliminates the distal segment of the amphid cilia. Mutations in three genes affect sensillar support cells. The
che-12 (e1812) mutation eliminates matrix material normally secreted by the amphid sheath cell. The
che-14 (e1960) mutation disrupts the joining of the amphid sheath and socket cells to form the receptor channel. A similar defect has been observed in
daf-6 mutants. Four additional genes affect specific classes of ciliated sensory neurons. The
mec-1 and
mec-8 (e398) mutations disrupt the fasciculation of the amphid cilia. The
cat-6 (e1861) mutation disrupts the tubular bodies of the CEP mechanocilia. A cryophilic thermotaxis mutant,
ttx-1 (p767), lacks fingers on the AFD dendrite, suggesting this neuron is thermosensory.</description><subject>ANALISIS</subject><subject>ANALYSE</subject><subject>ANALYSIS</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Biological and medical sciences</subject><subject>Body Temperature Regulation</subject><subject>Caenorhabditis - anatomy & histology</subject><subject>Caenorhabditis - genetics</subject><subject>Caenorhabditis - physiology</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Chemoreceptor Cells - ultrastructure</subject><subject>Cilia - physiology</subject><subject>Cilia - ultrastructure</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>CYTOPLASMIC ORGANELLES</subject><subject>Fluorescein-5-isothiocyanate</subject><subject>Fluoresceins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENETICA</subject><subject>GENETICS</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>GENETIQUE</subject><subject>Invertebrata</subject><subject>Ion Channels - physiology</subject><subject>Mechanoreceptors - physiology</subject><subject>Mechanoreceptors - ultrastructure</subject><subject>Microscopy, Electron</subject><subject>MOUVEMENT</subject><subject>MOVEMENT</subject><subject>MOVIMIENTO</subject><subject>MUTACION</subject><subject>MUTATION</subject><subject>NEMATODE</subject><subject>NEMATODES</subject><subject>NEMATODOS</subject><subject>ORGANITE CELLULAIRE</subject><subject>ORGANULOS CITOPLASMATICOS</subject><subject>Sensory Receptor Cells - physiology</subject><subject>Sensory Receptor Cells - ultrastructure</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Space life sciences</subject><subject>Thiocyanates - metabolism</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78AVHoQUQP1UmTpimCIItfoHhQwVuYplONdNM16Qr-e7vuskdPA_M-7zA8jB1wOOPA1TkAz1KuQJ1odVqC4DIVa2zEoczTXMm3dTZaIVtsO8ZPABBai022mclMK52N2MXjrEffJ5F87MJPYl3rMHE-6T8o8TTBvqspGSP5LnxgVbvexYRaekcfd9lGg22kveXcYa831y_ju_Th6fZ-fPWQWlnwPkXgvM4liYLQipIk2qqqCTGrICPgZWNRNMirss5AKkF5WepqWGktlYRK7LDjxd1p6L5mFHszcdFS26KnbhZNUUBeiEwNoFyANnQxBmrMNLgJhh_DwcydmbkQMxditDJ_zowYaofL-7NqQvWqtJQ05EfLHKPFtgnorYsrTIOUAHNsf4E12Bl8DwPy-qwLrnKRD-HlIqRB1LejYKJ15C3VLpDtTd25_5_8BTxxj6Q</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>Perkins, Lizabeth A.</creator><creator>Hedgecock, Edward M.</creator><creator>Thomson, J.Nichol</creator><creator>Culotti, Joseph G.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861001</creationdate><title>Mutant sensory cilia in the nematode Caenorhabditis elegans</title><author>Perkins, Lizabeth A. ; Hedgecock, Edward M. ; Thomson, J.Nichol ; Culotti, Joseph G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-a011d54e37eac39e4acbbdeaa2b02e019fca3fa1b9d20463e5998ba3f884640b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>ANALISIS</topic><topic>ANALYSE</topic><topic>ANALYSIS</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Body Temperature Regulation</topic><topic>Caenorhabditis - anatomy & histology</topic><topic>Caenorhabditis - genetics</topic><topic>Caenorhabditis - physiology</topic><topic>Chemoreceptor Cells - physiology</topic><topic>Chemoreceptor Cells - ultrastructure</topic><topic>Cilia - physiology</topic><topic>Cilia - ultrastructure</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>CYTOPLASMIC ORGANELLES</topic><topic>Fluorescein-5-isothiocyanate</topic><topic>Fluoresceins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENETICA</topic><topic>GENETICS</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>GENETIQUE</topic><topic>Invertebrata</topic><topic>Ion Channels - physiology</topic><topic>Mechanoreceptors - physiology</topic><topic>Mechanoreceptors - ultrastructure</topic><topic>Microscopy, Electron</topic><topic>MOUVEMENT</topic><topic>MOVEMENT</topic><topic>MOVIMIENTO</topic><topic>MUTACION</topic><topic>MUTATION</topic><topic>NEMATODE</topic><topic>NEMATODES</topic><topic>NEMATODOS</topic><topic>ORGANITE CELLULAIRE</topic><topic>ORGANULOS CITOPLASMATICOS</topic><topic>Sensory Receptor Cells - physiology</topic><topic>Sensory Receptor Cells - ultrastructure</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Space life sciences</topic><topic>Thiocyanates - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perkins, Lizabeth A.</creatorcontrib><creatorcontrib>Hedgecock, Edward M.</creatorcontrib><creatorcontrib>Thomson, J.Nichol</creatorcontrib><creatorcontrib>Culotti, Joseph G.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perkins, Lizabeth A.</au><au>Hedgecock, Edward M.</au><au>Thomson, J.Nichol</au><au>Culotti, Joseph G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutant sensory cilia in the nematode Caenorhabditis elegans</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>117</volume><issue>2</issue><spage>456</spage><epage>487</epage><pages>456-487</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><coden>DEBIAO</coden><abstract>Eight classes of chemosensory neurons in
C. elegans fill with fluorescein when living animals are placed in a dye solution. Fluorescein enters the neurons through their exposed sensory cilia. Mutations in 14 genes prevent dye uptake and disrupt chemosensory behaviors. Each of these genes affects the ultrastructure of the chemosensory cilia or their accessory cells. In each case, the cilia are shorter or less exposed than normal, suggesting that dye contact is the principal factor under selection. Ten genes affect many or all of the sensory cilia in the head. The
daf-19 (m86) mutation eliminates all cilia, leaving only occasional centrioles in the dendrites. The cilia in
che-13 (e1805), osm-1 (p808), osm-5 (p813), and
osm-6 (p811) mutants have normal transition zones and severely shortened axonemes. Doublet-microtubules, attached to the membrane by Y links, assemble ectopically proximal to the cilia in these mutants. The amphid cilia in
che-11 (e1810) are irregular in diameter and contain dark ground material in the middle of the axonemes. Certain mechanocilia are also affected. The amphid cilia in
che-10 (e1809) apparently degenerate, leaving dendrites with bulb-shaped endings filled with dark ground material. The mechanocilia lack striated rootlets. Cilia defects have also been found in
che-2, che-3, and
daf-10 mutants. The
osm-3 (p802) mutation specifically eliminates the distal segment of the amphid cilia. Mutations in three genes affect sensillar support cells. The
che-12 (e1812) mutation eliminates matrix material normally secreted by the amphid sheath cell. The
che-14 (e1960) mutation disrupts the joining of the amphid sheath and socket cells to form the receptor channel. A similar defect has been observed in
daf-6 mutants. Four additional genes affect specific classes of ciliated sensory neurons. The
mec-1 and
mec-8 (e398) mutations disrupt the fasciculation of the amphid cilia. The
cat-6 (e1861) mutation disrupts the tubular bodies of the CEP mechanocilia. A cryophilic thermotaxis mutant,
ttx-1 (p767), lacks fingers on the AFD dendrite, suggesting this neuron is thermosensory.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2428682</pmid><doi>10.1016/0012-1606(86)90314-3</doi><tpages>32</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1606 |
| ispartof | Developmental biology, 1986-10, Vol.117 (2), p.456-487 |
| issn | 0012-1606 1095-564X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77057326 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | ANALISIS ANALYSE ANALYSIS Animals Behavior, Animal - physiology Biological and medical sciences Body Temperature Regulation Caenorhabditis - anatomy & histology Caenorhabditis - genetics Caenorhabditis - physiology Chemoreceptor Cells - physiology Chemoreceptor Cells - ultrastructure Cilia - physiology Cilia - ultrastructure Classical genetics, quantitative genetics, hybrids CYTOPLASMIC ORGANELLES Fluorescein-5-isothiocyanate Fluoresceins - metabolism Fundamental and applied biological sciences. Psychology GENETICA GENETICS Genetics of eukaryotes. Biological and molecular evolution GENETIQUE Invertebrata Ion Channels - physiology Mechanoreceptors - physiology Mechanoreceptors - ultrastructure Microscopy, Electron MOUVEMENT MOVEMENT MOVIMIENTO MUTACION MUTATION NEMATODE NEMATODES NEMATODOS ORGANITE CELLULAIRE ORGANULOS CITOPLASMATICOS Sensory Receptor Cells - physiology Sensory Receptor Cells - ultrastructure Sexual Behavior, Animal - physiology Space life sciences Thiocyanates - metabolism |
| title | Mutant sensory cilia in the nematode Caenorhabditis elegans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T15%3A37%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mutant%20sensory%20cilia%20in%20the%20nematode%20Caenorhabditis%20elegans&rft.jtitle=Developmental%20biology&rft.au=Perkins,%20Lizabeth%20A.&rft.date=1986-10-01&rft.volume=117&rft.issue=2&rft.spage=456&rft.epage=487&rft.pages=456-487&rft.issn=0012-1606&rft.eissn=1095-564X&rft.coden=DEBIAO&rft_id=info:doi/10.1016/0012-1606(86)90314-3&rft_dat=%3Cproquest_cross%3E77057326%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77057326&rft_id=info:pmid/2428682&rft_els_id=0012160686903143&rfr_iscdi=true |