Reversible shear-mediated platelet dysfunction during cardiac surgery as assessed by the PFA-100® platelet function analyzer

We undertook this investigation to assess alterations in shear-mediated platelet function during cardiac surgery and to determine the potential for the PFA-100 to predict post-operative bleeding. Platelet aggregation and PFA-100 closure times were determined in 18 adult patients at five intervals du...

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Veröffentlicht in:	Blood coagulation & fibrinolysis 2001-03, Vol.12 (2), p.85-93
Hauptverfasser:	Slaughter, T F, Sreeram, G, Sharma, A D, El-Moalem, H, East, C J, Greenberg, C S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adult Autoanalysis - instrumentation Biological and medical sciences Blood Platelets - drug effects Blood Platelets - physiology Cardiopulmonary Bypass Collagen - pharmacology Epinephrine - pharmacology Hematocrit Hemorheology Hemostasis Heparin - pharmacology Humans Medical sciences Platelet Adhesiveness - drug effects Platelet Aggregation - drug effects Postoperative Hemorrhage - diagnosis Protamines - pharmacology Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors von Willebrand Factor - pharmacology
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