Regulation of Differentiation to the Infective Stage of the Protozoan Parasite Leishmania major by Tetrahydrobiopterin

A critical step in the infectious cycle of Leishmania is the differentiation of parasites within the sand fly vector to the highly infective metacyclic promastigote stage. Here, we establish tetrahydrobiopterin (H4B) levels as an important factor controlling the extent of metacyclogenesis. H4Blevels...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2001-04, Vol.292 (5515), p.285-287
Hauptverfasser:	Cunningham, Mark L., Titus, Richard G., Turco, Salvatore J., Beverley, Stephen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and medical sciences Biopterins - analogs & derivatives Biopterins - metabolism Biopterins - pharmacology Carrier Proteins - genetics Carrier Proteins - metabolism Chromatography, High Pressure Liquid Evolution Folic Acid - metabolism Fundamental and applied biological sciences. Psychology Genes, Protozoan Genetics Glycosphingolipids - analysis Human protozoal diseases Individualized Instruction Infectious diseases Leishmania major Leishmania major - genetics Leishmania major - growth & development Leishmania major - metabolism Leishmania major - pathogenicity Leishmaniasis Leishmaniasis, Cutaneous - parasitology Leshmaniasis Lesions Life cycle. Host-agent relationship. Pathogenesis Medical sciences Membrane Transport Proteins Metabolism Mice Mice, Inbred BALB C Molecular Sequence Data Mutation Nutrition Oxidoreductases - genetics Oxidoreductases - metabolism Parasite hosts Parasites Parasitic diseases Parasitism Promastigotes Protozoa Protozoal diseases Protozoan Proteins pteridine pteridine reductase 1 Pteridines Signal Transduction Steepest descent method tetrahydrobiopterin Virulence
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!