Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications

Numerous physiological aldehydes besides glucose are substrates of aldose reductase, the first enzyme of the polyol pathway which has been implicated in the etiology of diabetic complications. The 2-oxoaldehyde methylglyoxal is a preferred substrate of aldose reductase but is also the main physiolog...

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Veröffentlicht in:	Chemico-biological interactions 2001-01, Vol.130 (1-3), p.549-562
Hauptverfasser:	Vander Jagt, David L., Hassebrook, Robyn K., Hunsaker, Lucy A., Brown, William M., Royer, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-oxoaldehydes Aldehyde Reductase - chemistry Aldehyde Reductase - metabolism Aldose reductase Binding Sites Diabetes Complications Diabetes Mellitus - metabolism Glutathione Glutathione - metabolism Humans In Vitro Techniques Kinetics Lactoylglutathione Lyase - metabolism Methylglyoxal Models, Biological Models, Molecular Oxidation-Reduction Protein Conformation Pyruvaldehyde - metabolism Substrate Specificity
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