HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

In vivo infection of lymphatic tissues by the human immunodeficiency virus type 1 (HIV-1) leads to enhanced apoptosis, which prominently involves uninfected bystander cells 1 , 2 , 3 . Increased killing of such bystander cells is mediated in part through Nef induction of Fas ligand (FasL) expression...

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Veröffentlicht in:	Nature (London) 2001-04, Vol.410 (6830), p.834-838
Hauptverfasser:	Geleziunas, Romas, Xu, Weiduan, Takeda, Kohsuke, Ichijo, Hidenori, Greene, Warner C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis ASK1 protein Biological and medical sciences Catalysis Cell Line Cells Cellular biology Enzyme Inhibitors Fas Ligand Protein FasL protein Fundamental and applied biological sciences. Psychology Gene Products, nef - physiology HIV Human immunodeficiency virus Human immunodeficiency virus 1 Humanities and Social Sciences Humans Immunology Jurkat Cells letter Lymphocytes MAP Kinase Kinase Kinase 5 MAP Kinase Kinase Kinases - antagonists & inhibitors Membrane Glycoproteins - metabolism Microbiology Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases - metabolism multidisciplinary Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Science Science (multidisciplinary) Signal Transduction T-Lymphocytes - metabolism T-Lymphocytes - virology Tissues Tumor Necrosis Factor-alpha - metabolism Virology
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