Analysis of Peroxynitrite Reactions with Guanine, Xanthine, and Adenine Nucleosides by High-Pressure Liquid Chromatography with Electrochemical Detection:  C8-Nitration and -Oxidation

Peroxynitrite, the reaction product of nitric oxide and superoxide anion, and a powerful oxidant, was found to nitrate as well as oxidize adenine, guanine, and xanthine nucleosides. A highly sensitive reverse-phase HPLC method with a dual-mode electrochemical detector, which reduces the nitro produc...

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Veröffentlicht in:	Chemical research in toxicology 2001-04, Vol.14 (4), p.438-450
Hauptverfasser:	Sodum, Rama S, Fiala, Emerich S
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Nitroguanine 8-Nitroxanthine Adenine - chemistry Chromatography, High Pressure Liquid - methods Electrochemistry Guanine - chemistry Nitrates - chemistry nucleosides Oxidation-Reduction Purine Nucleosides - chemistry Xanthine - chemistry
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