Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells

The molecular mechanisms mediating the retinogenic potential of multipotent retinal progenitor cells (RPCs) are poorly defined. Prior to initiating retinogenesis, RPCs express a limited set of transcription factors implicated in the evolutionary ancient genetic network that initiates eye development...

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Veröffentlicht in:	Cell 2001-04, Vol.105 (1), p.43-55
Hauptverfasser:	Marquardt, Till, Ashery-Padan, Ruth, Andrejewski, Nicole, Scardigli, Raffaella, Guillemot, Francois, Gruss, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Lineage Chick Embryo Clone Cells - cytology Eye Proteins Gene Targeting Helix-Loop-Helix Motifs Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Interneurons - cytology Interneurons - metabolism Membrane Proteins - metabolism Mice Mice, Transgenic Morphogenesis Neurotransmitter Agents - metabolism Paired Box Transcription Factors Pax6 protein PAX6 Transcription Factor Phenotype Qa-SNARE Proteins Repressor Proteins Retina - cytology Retina - embryology Retina - metabolism Stem Cells - cytology Stem Cells - metabolism Transcription Factors - metabolism Transcriptional Activation
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