The Conformation of the Lysyl Side Chain of Substrates at the Active Center of Trypsin

In order to study the conformation of the side chain of lysine substrates bound to the active center of trypsin, two lysine analogs, cis- and trans-2,6-diamino-4-hexenoic acids (4,5-dehydrolysines) were synthesized and kinetic parameters for the hydrolysis of benzoyl methyl esters and phenylthiazolo...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 1986-07, Vol.100 (1), p.21-25
Hauptverfasser:	MIZUSAKI, Koichi, SUGAHARA, Yuji, TSUNEMATSU, Hideaki, MAKISUMI, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Binding Sites Biological and medical sciences Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Hydrolysis Indicators and Reagents Kinetics Lysine - analogs & derivatives Protein Conformation Substrate Specificity Trypsin - metabolism
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